C57BL/6JCya-Adgrg7em1/Cya
Common Name:
Adgrg7-KO
Product ID:
S-KO-17884
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Adgrg7-KO
Strain ID
KOCMP-239853-Adgrg7-B6J-VB
Gene Name
Product ID
S-KO-17884
Gene Alias
9130020O16Rik; Gpr128
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
16
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Adgrg7em1/Cya mice (Catalog S-KO-17884) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000023437
NCBI RefSeq
NM_172825
Target Region
Exon 4
Size of Effective Region
~0.1 kb
Detailed Document
Overview of Gene Research
Adgrg7, also known as GPR128, is an adhesion G protein-coupled receptor. Adhesion GPCRs are involved in various physiological processes, and Adgrg7 may play a role in processes such as reduced body weight, gastrointestinal function, and was recently associated with adolescent idiopathic scoliosis [3]. It has also been identified as an estrogen-responsive gene regulated by estrogen receptor ERα and SP1 in scoliotic osteoblasts and other cell lines [3].
In a study of SARS-CoV-2 infection, the mRNA levels of Adgrg7 were significantly increased in SARS-CoV-2-infected lung adenocarcinoma Calu-3 cells, and down-regulation of Adgrg7 led to a decrease in the amount of newly released SARS-CoV-2 and its infectivity, suggesting its possible role in the viral infection process [2]. In breast cancer, high expression of Adgrg7 was significantly correlated with poor overall survival of patients, indicating its potential association with breast cancer development [5]. Also, a rare TFG-Adgrg7 fusion was detected in mesothelioma of the tunica vaginalis testis, though its significance in this disease is yet to be fully understood [1]. A polymorphic gene fusion TFG-Adgrg7 was identified in the GTEx cohort, with distinct patterns across different ancestry groups [4].
In conclusion, Adgrg7 is an adhesion G protein-coupled receptor with potential functions in multiple physiological and disease-related processes, including viral infection, breast cancer, and potentially mesothelioma. Studies on Adgrg7 help in understanding the complex biological processes and disease mechanisms, which may provide new directions for related disease treatment and prevention.
References:
1. Højsager, Katia Damsgaard, Kobberø, Hanne, Santoni-Rugiu, Eric, Land, Lotte Holm, Sørensen, Jens Benn. 2024. [Not Available]. In Ugeskrift for laeger, 186, . doi:10.61409/V07230476. https://pubmed.ncbi.nlm.nih.gov/38305267/
2. Žáčková, Sandra, Pávová, Marcela, Trylčová, Jana, Lukšan, Ondřej, Weber, Jan. 2024. Upregulation of mRNA Expression of ADGRD1/GPR133 and ADGRG7/GPR128 in SARS-CoV-2-Infected Lung Adenocarcinoma Calu-3 Cells. In Cells, 13, . doi:10.3390/cells13100791. https://pubmed.ncbi.nlm.nih.gov/38786015/
3. Hassan, Amani, Bagu, Edward T, Levesque, Mathieu, Tremblay, André, Moldovan, Florina. 2019. The 17β-estradiol induced upregulation of the adhesion G-protein coupled receptor (ADGRG7) is modulated by ESRα and SP1 complex. In Biology open, 8, . doi:10.1242/bio.037390. https://pubmed.ncbi.nlm.nih.gov/30598481/
4. Elfman, Justin, Goins, Lynette, Heller, Tessa, Wang, Yuh-Hwa, Li, Hui. . Discovery of a polymorphic gene fusion via bottom-up chimeric RNA prediction. In Nucleic acids research, 52, 4409-4421. doi:10.1093/nar/gkae258. https://pubmed.ncbi.nlm.nih.gov/38587197/
5. Shi, Wenning, Xu, Cong, Lei, Ping, Wang, Hongmei, Zhang, Dao-Lai. 2024. A correlation study of adhesion G protein-coupled receptors as potential therapeutic targets for breast cancer. In Breast cancer research and treatment, 207, 417-434. doi:10.1007/s10549-024-07373-z. https://pubmed.ncbi.nlm.nih.gov/38834774/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen