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C57BL/6JCya-Cpne1em1/Cya
Common Name:
Cpne1-KO
Product ID:
S-KO-17890
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Cpne1-KO
Strain ID
KOCMP-266692-Cpne1-B6J-VA
Gene Name
Cpne1
Product ID
S-KO-17890
Gene Alias
1810028N16Rik; mKIAA4108
Background
C57BL/6JCya
NCBI ID
266692
Modification
Conventional knockout
Chromosome
2
Phenotype
MGI:2386621
Document
Click here to download >>
Application
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Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Cpne1em1/Cya mice (Catalog S-KO-17890) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000109608
NCBI RefSeq
NM_170588
Target Region
Exon 3~14
Size of Effective Region
~3.8 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Cpne1, a calcium-dependent, phospholipid-binding protein, is ubiquitously expressed in various tissues and organs. It is involved in multiple biological processes and associated with several signaling pathways. For example, it can interact with proteins like 14-3-3γ, Jab1, HAX1, TRAF2, and RACK1, and is related to pathways such as MAPK, PERK-eIF2α, MET, PI3K/AKT/HIF-1α, and AKT/P53 [1-10]. Cpne1 plays an important role in cell proliferation, differentiation, apoptosis, and mitochondrial function, and is also implicated in the development of many diseases, especially various cancers [1-10]. Genetic models, such as knockout mouse models, are valuable for studying its functions.

In gastric, pancreatic, non-small cell lung, breast, and hepatocellular cancers, silencing Cpne1 inhibits cell proliferation, promotes apoptosis, and suppresses tumor growth in vitro and in vivo [1,3,5,6,7]. In sarcopenia, overexpression of Cpne1 in young muscles disrupts mitochondrial function, affects membrane lipid composition, and reduces skeletal muscle fibrosis regeneration and exercise capacity, which can be reversed by a PERK inhibitor [2]. In the context of sperm motility, Cpne1 deficiency preserves sperm motility under Ca2+ channel blockade, suggesting it may be a target of Ca2+ channel inhibitors [4].

In conclusion, Cpne1 is crucial in regulating cell-related biological processes. The use of Cpne1 KO mouse models has significantly contributed to understanding its role in cancer development, sarcopenia, and sperm motility regulation. These findings provide potential therapeutic targets for related diseases.

References:
1. Li, Yan, Li, Lixiang, Liu, Han, Zhou, Tao. 2022. CPNE1 silencing inhibits cell proliferation and accelerates apoptosis in human gastric cancer. In European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 177, 106278. doi:10.1016/j.ejps.2022.106278. https://pubmed.ncbi.nlm.nih.gov/35985444/
2. Chen, Lin, Pan, Ling, Zeng, Yuexi, Zhu, Xiaonan, You, Li. 2022. CPNE1 regulates myogenesis through the PERK-eIF2α pathway mediated by endoplasmic reticulum stress. In Cell and tissue research, 391, 545-560. doi:10.1007/s00441-022-03720-y. https://pubmed.ncbi.nlm.nih.gov/36525128/
3. Song, Yelin, Song, Baolian, Yu, Zhichao, Lu, Zhongwen, Li, Zuowei. . Silencing of CPNE1-TRAF2 Axis Restrains the Development of Pancreatic Cancer. In Frontiers in bioscience (Landmark edition), 28, 316. doi:10.31083/j.fbl2811316. https://pubmed.ncbi.nlm.nih.gov/38062811/
4. Xie, Qiang, Zhang, Hanbin, Zhuang, Yuge, Chen, Zhenguo, Zhang, Guofei. 2024. Cpne1 deficiency preserves sperm motility under Ca2+ channel blockade. In The Journal of reproduction and development, 70, 309-319. doi:10.1262/jrd.2024-027. https://pubmed.ncbi.nlm.nih.gov/39010238/
5. Wang, Anqi, Yang, Wen, Li, Yue, Liu, Zeyi, Huang, Jian-An. 2022. CPNE1 promotes non-small cell lung cancer progression by interacting with RACK1 via the MET signaling pathway. In Cell communication and signaling : CCS, 20, 16. doi:10.1186/s12964-021-00818-8. https://pubmed.ncbi.nlm.nih.gov/35101055/
6. Cao, Jingying, Cao, Renxian, Liu, Yiqi, Dai, Tao. 2023. CPNE1 mediates glycolysis and metastasis of breast cancer through activation of PI3K/AKT/HIF-1α signaling. In Pathology, research and practice, 248, 154634. doi:10.1016/j.prp.2023.154634. https://pubmed.ncbi.nlm.nih.gov/37454492/
7. Su, Jinfang, Huang, Yongbiao, Wang, Yali, Zhang, Hao, Xiong, Huihua. 2022. CPNE1 is a potential prognostic biomarker, associated with immune infiltrates and promotes progression of hepatocellular carcinoma. In Cancer cell international, 22, 67. doi:10.1186/s12935-022-02485-2. https://pubmed.ncbi.nlm.nih.gov/35139863/
Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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