C57BL/6JCya-H19em1/Cya
Common Name
H19-KO
Product ID
S-KO-17898
Backgroud
C57BL/6JCya
Strain ID
KOCMP-14955-H19-B6J-VA
When using this mouse strain in a publication, please cite “H19-KO Mouse (Catalog S-KO-17898) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
H19-KO
Strain ID
KOCMP-14955-H19-B6J-VA
Gene Name
Product ID
S-KO-17898
Gene Alias
EyeLinc6
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 7
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000136359
NCBI RefSeq
NR_130973
Target Region
Exon 1~5
Size of Effective Region
~3.1 kb
Overview of Gene Research
H19 is a long non-coding RNA (lncRNA). It is an imprinted gene, normally expressed from the maternal allele. H19 is involved in multiple biological processes and has been associated with various diseases, especially cancers. It functions in the regulation of cell growth, proliferation, and metastasis through multiple pathways, such as the lncRNA-microRNA-messenger RNA-competitive endogenous RNA (ceRNA) network [1,2,3,4,6].
In cancer research, H19 has been shown to play oncogenic roles. In colorectal cancer, it aids in cell growth, invasion, and metastasis. Inhibition of H19 in hepatic cells can affect endoplasmic reticulum-mitochondria contact and gluconeogenesis [3,5]. In colorectal cancer, carcinoma-associated fibroblasts can promote cancer stemness and chemoresistance by transferring exosomal H19 [6]. H19 also confers chemoresistance in various cancers like breast, lung, glioma, and liver cancer through mechanisms such as induction of EMT and activation of oncogenic signaling pathways [7].
In conclusion, H19 is a significant lncRNA involved in cancer development, metastasis, and chemoresistance. Its role in cancer-related biological processes has been revealed through in-vivo studies, which provides potential therapeutic targets for cancer treatment. The understanding of H19's function helps in deciphering the molecular mechanisms of cancer and may contribute to the development of new treatment strategies [1,2,3,4,6,7,8].
References：
1. Ghafouri-Fard, Soudeh, Esmaeili, Mohammadhosein, Taheri, Mohammad. 2019. H19 lncRNA: Roles in tumorigenesis. In Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 123, 109774. doi:10.1016/j.biopha.2019.109774. https://pubmed.ncbi.nlm.nih.gov/31855739/
2. Hashemi, Mehrdad, Moosavi, Marzieh Sadat, Abed, Hedyeh Maghareh, Mirzaei, Sepideh, Samarghandian, Saeed. 2022. Long non-coding RNA (lncRNA) H19 in human cancer: From proliferation and metastasis to therapy. In Pharmacological research, 184, 106418. doi:10.1016/j.phrs.2022.106418. https://pubmed.ncbi.nlm.nih.gov/36038043/
3. Chowdhury, Prerana R, Salvamani, Shamala, Gunasekaran, Baskaran, Peng, Hoh B, Ulaganathan, Vaidehi. 2023. H19: An Oncogenic Long Non-coding RNA in Colorectal Cancer. In The Yale journal of biology and medicine, 96, 495-509. doi:10.59249/TDBJ7410. https://pubmed.ncbi.nlm.nih.gov/38161577/
4. Yang, Jun, Qi, Manlong, Fei, Xiang, Wang, Xia, Wang, Kefeng. 2021. LncRNA H19: A novel oncogene in multiple cancers. In International journal of biological sciences, 17, 3188-3208. doi:10.7150/ijbs.62573. https://pubmed.ncbi.nlm.nih.gov/34421359/
5. Nandwani, Arun, Rathore, Shalu, Datta, Malabika. 2023. LncRNA H19 inhibition impairs endoplasmic reticulum-mitochondria contact in hepatic cells and augments gluconeogenesis by increasing VDAC1 levels. In Redox biology, 69, 102989. doi:10.1016/j.redox.2023.102989. https://pubmed.ncbi.nlm.nih.gov/38100882/
6. Ren, Jing, Ding, Liang, Zhang, Dongya, Wang, Tingting, Hou, Yayi. 2018. Carcinoma-associated fibroblasts promote the stemness and chemoresistance of colorectal cancer by transferring exosomal lncRNA H19. In Theranostics, 8, 3932-3948. doi:10.7150/thno.25541. https://pubmed.ncbi.nlm.nih.gov/30083271/
7. Ghafouri-Fard, Soudeh, Shoorei, Hamed, Bahroudi, Zahra, Abak, Atefe, Taheri, Mohammad. 2021. The role of H19 lncRNA in conferring chemoresistance in cancer cells. In Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 138, 111447. doi:10.1016/j.biopha.2021.111447. https://pubmed.ncbi.nlm.nih.gov/33667788/
8. Zhang, Xun, Luo, Mingpeng, Zhang, Jiahang, Zhou, Yulu, Zhou, Jichun. 2022. The role of lncRNA H19 in tumorigenesis and drug resistance of human Cancers. In Frontiers in genetics, 13, 1005522. doi:10.3389/fgene.2022.1005522. https://pubmed.ncbi.nlm.nih.gov/36246634/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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