Logo
Homepage
Explore Our Models
My Cart
Contact
Subscribe
Models
Genetically Engineered Animals
Knockout Mice
Knockout Rats
Knockin Mice
Knockin Rats
Transgenic Mice
Transgenic Rats
Model Generation Techniques
Turboknockout<sup>®</sup> Gene Targeting
ES Cell Gene Targeting
Targeted Gene Editing
Regular Transgenic
PiggyBac Transgenesis
BAC Transgenic
Research Models
HUGO-GT™ Humanized Mice
Cre Mouse Lines
Humanized Target Gene Models
Metabolic Disease Models
Ophthalmic Disease Models
Neurological Disease Models
Autoimmune Disease Models
Immunodeficient Mouse Models
Humanized Immune System Mouse Models
Oncology & Immuno-oncology Models
Covid-19 Mouse Models
MouseAtlas Model Library
Knockout Cell Line Product Catalog
Tumor Cell Line Product Catalog
AAV Standard Product Catalog
Animal Supporting Services
Breeding Services
Cryopreservation & Recovery
Phenotyping Services
BAC Modification
Custom Cell Line Models
Induced Pluripotent Stem Cells (iPSCs)
Knockout Cell Lines
Knockin Cell Lines
Point Mutation Cell Lines
Overexpression Cell Lines
Virus Packaging
Adeno-associated Virus (AAV) Packaging
Lentivirus Packaging
Adenovirus Packaging
CRO Services
By Therapeutic Area
Oncology
Ophthalmology
Neuroscience
Metabolic & Cardiovascular Diseases
Autoimmune & Inflammatory
By Drug Type
AI-Powered AAV Discovery
Gene Therapy
Oligonucleotide Therapy
Antibody Therapy
Cell Immunotherapy
Resources
Promotion
Events & Webinars
Newsroom
Blogs & Insights
Resource Vault
Reference Databases
Peer-Reviewed Citations
Rare Disease Data Center
AbSeek
Cell iGeneEditor™ System
OriCell
Quality
Facility Overview
Animal Health & Welfare
Health Reports
About Us
Corporate Overview
Our Partners
Careers
Contact Us
Login
Request a Product Quote
Select products from our catalogs and submit your request. Our team will get back to you with detailed information.
Full Name
Email
Phone Number
Organization
Job Role
Country
Catalog Type
Product Name
Additional Comments
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.
C57BL/6JCya-Foxd2em1/Cya
Common Name:
Foxd2-KO
Product ID:
S-KO-17923
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Foxd2-KO
Strain ID
KOCMP-17301-Foxd2-B6J-VB
Gene Name
Foxd2
Product ID
S-KO-17923
Gene Alias
Mf2
Background
C57BL/6JCya
NCBI ID
17301
Modification
Conventional knockout
Chromosome
4
Phenotype
MGI:1347471
Document
Click here to download >>
Application
--
More
Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Foxd2em1/Cya mice (Catalog S-KO-17923) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000068654
NCBI RefSeq
NM_008593
Target Region
Exon 1
Size of Effective Region
~3.4 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Foxd2, belonging to the Forkhead-box (FOX) gene family, is likely involved in a range of biological processes. Although the provided references mainly focus on FOXD2-AS1, a long non-coding RNA, it's worth noting that genes in the FOX family are associated with various functions, and deregulation can lead to congenital disorders, diabetes, or carcinogenesis [7].

Most of the references center on FOXD2-AS1 rather than Foxd2 itself. FOXD2-AS1 is up-regulated in almost all types of malignancies and impacts multiple pathways such as PI3K/AKT, AKT/mTOR, Hippo/YAP, Notch, Nrf2, Wnt/β-catenin, NF-κB, and ERK/MAPK. It enhances cancer stem cell properties, prompts epithelial-mesenchymal transition, and induces resistance to many anticancer agents [1]. In various cancers like gastric, lung, bladder, etc., its up-regulation contributes to cancer cell proliferation, migration, and invasion, and is related to patient survival and prognosis [2,3]. In glioma, it stimulates progression by inhibiting P53 [4]. In esophageal squamous cell carcinoma, it acts as an oncogene by sponging miR-204-3p [5]. In lung adenocarcinoma, it increases proliferation and invasion via cell-cycle regulation [6]. In retinoblastoma, it promotes cell viability and migration by sponging miR-31 [8]. In hepatocellular carcinoma, it facilitates progression by regulating TWIST1 [9]. In osteoarthritis, it induces chondrocyte proliferation by sponging miR-27a-3p [10].

In conclusion, while direct functional studies on Foxd2 from the provided references are scarce, the associated lncRNA FOXD2-AS1 clearly plays significant roles in cancer progression and other disease conditions. Understanding the functions of Foxd2 and its related molecules like FOXD2-AS1 is crucial for uncovering disease mechanisms and developing potential therapeutic strategies.

References:
1. Ghafouri-Fard, Soudeh, Harsij, Atefeh, Hussen, Bashdar Mahmud, Pourmoshtagh, Hasan, Taheri, Mohammad. 2024. A review on the role of FOXD2-AS1 in human disorders. In Pathology, research and practice, 254, 155101. doi:10.1016/j.prp.2024.155101. https://pubmed.ncbi.nlm.nih.gov/38211387/
2. Hu, Qiuhui, Tai, Sheng, Wang, Jicai. 2019. Oncogenicity of lncRNA FOXD2-AS1 and its molecular mechanisms in human cancers. In Pathology, research and practice, 215, 843-848. doi:10.1016/j.prp.2019.01.033. https://pubmed.ncbi.nlm.nih.gov/30723052/
3. Zhang, Yongping, Liang, Chaojie, Zhang, Yu, Wei, Zhigang, Guo, Jiansheng. . The role of FOXD2-AS1 in cancer: a comprehensive study based on data mining and published articles. In Bioscience reports, 40, . doi:10.1042/BSR20190372. https://pubmed.ncbi.nlm.nih.gov/33140822/
4. Zhao, Q-S, Ying, J-B, Jing, J-J, Wang, S-S. . LncRNA FOXD2-AS1 stimulates glioma progression through inhibiting P53. In European review for medical and pharmacological sciences, 24, 4382-4388. doi:10.26355/eurrev_202004_21019. https://pubmed.ncbi.nlm.nih.gov/32373975/
5. Luo, Dongbo, Salai, Adili, Lv, Hongbo, Wang, Yang, Gao, Yunfei. 2022. FOXD2-AS1 acts an oncogene in esophageal squamous cell carcinoma through sponging miR-204-3p. In Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 24, 1954-1963. doi:10.1007/s12094-022-02850-7. https://pubmed.ncbi.nlm.nih.gov/35778646/
6. Yuan, Yuan, Yu, Peng, Shen, Huihua, Xing, Guozhu, Li, Wu. 2023. LncRNA FOXD2-AS1 Increased Proliferation and Invasion of Lung Adenocarcinoma via Cell-Cycle Regulation. In Pharmacogenomics and personalized medicine, 16, 99-109. doi:10.2147/PGPM.S396866. https://pubmed.ncbi.nlm.nih.gov/36761100/
7. Katoh, Masuko, Katoh, Masaru. . Human FOX gene family (Review). In International journal of oncology, 25, 1495-500. doi:. https://pubmed.ncbi.nlm.nih.gov/15492844/
8. Liang, Yan, Wang, Hong, Song, Ruiying, Yin, Xiuyan. 2022. lncRNA FOXD2-AS1 Promotes the Retinoblastoma Cell Viability and Migration by Sponging miR-31. In BioMed research international, 2022, 7723425. doi:10.1155/2022/7723425. https://pubmed.ncbi.nlm.nih.gov/35782084/
9. Chen, G, Zhang, W-L, Zhang, S-M, Tang, K-L, Zhang, Y. . LncRNA FOXD2-AS1 facilitates the progression of hepatocellular carcinoma by regulating TWIST1. In European review for medical and pharmacological sciences, 27, 4536-4543. doi:10.26355/eurrev_202305_32460. https://pubmed.ncbi.nlm.nih.gov/37259735/
10. Wang, Yang, Cao, Lei, Wang, Qiugen, Huang, Jianhua, Xu, Shuogui. . LncRNA FOXD2-AS1 induces chondrocyte proliferation through sponging miR-27a-3p in osteoarthritis. In Artificial cells, nanomedicine, and biotechnology, 47, 1241-1247. doi:10.1080/21691401.2019.1596940. https://pubmed.ncbi.nlm.nih.gov/30945573/
Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
Model Library
Model Library
Resources
Resources
Animal Quality
Animal Quality
Get Support
Get Support
Address:
2255 Martin Avenue, Suite E Santa Clara, CA 95050-2709, US
Tel:
800-921-8930 (8-6pm PST)
+1408-963-0306 (lnt’l)
Fax:
408-969-0338
Email:
animal-service@cyagen.com
service@cyagen.us
CRO Services
OncologyOphthalmologyNeuroscienceMetabolic & CardiovascularAutoimmune & InflammatoryGene TherapyAntibody Therapy
About Us
Corporate OverviewOur PartnersCareersContact Us
Social Media
Disclaimer: Pricing and availability of our products and services vary by region. Listed prices are applicable to the specific countries. Please contact us for more information.
Copyright © 2025 Cyagen. All rights reserved.
Privacy Policy
Site Map
Stay Updated with the Latest from Cyagen
Get the latest news on our research models, CRO services, scientific resources, and special offers—tailored to your research needs and delivered straight to your inbox.
Full Name
Email
Organization
Country
Areas of Interest