C57BL/6JCya-Foxd2em1/Cya
Common Name:
Foxd2-KO
Product ID:
S-KO-17923
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Foxd2-KO
Strain ID
KOCMP-17301-Foxd2-B6J-VB
Gene Name
Product ID
S-KO-17923
Gene Alias
Mf2
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
4
Phenotype
Document
Application
--
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Foxd2em1/Cya mice (Catalog S-KO-17923) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000068654
NCBI RefSeq
NM_008593
Target Region
Exon 1
Size of Effective Region
~3.4 kb
Detailed Document
Overview of Gene Research
Foxd2, belonging to the Forkhead-box (FOX) gene family, is likely involved in a range of biological processes. Although the provided references mainly focus on FOXD2-AS1, a long non-coding RNA, it's worth noting that genes in the FOX family are associated with various functions, and deregulation can lead to congenital disorders, diabetes, or carcinogenesis [7].
Most of the references center on FOXD2-AS1 rather than Foxd2 itself. FOXD2-AS1 is up-regulated in almost all types of malignancies and impacts multiple pathways such as PI3K/AKT, AKT/mTOR, Hippo/YAP, Notch, Nrf2, Wnt/β-catenin, NF-κB, and ERK/MAPK. It enhances cancer stem cell properties, prompts epithelial-mesenchymal transition, and induces resistance to many anticancer agents [1]. In various cancers like gastric, lung, bladder, etc., its up-regulation contributes to cancer cell proliferation, migration, and invasion, and is related to patient survival and prognosis [2,3]. In glioma, it stimulates progression by inhibiting P53 [4]. In esophageal squamous cell carcinoma, it acts as an oncogene by sponging miR-204-3p [5]. In lung adenocarcinoma, it increases proliferation and invasion via cell-cycle regulation [6]. In retinoblastoma, it promotes cell viability and migration by sponging miR-31 [8]. In hepatocellular carcinoma, it facilitates progression by regulating TWIST1 [9]. In osteoarthritis, it induces chondrocyte proliferation by sponging miR-27a-3p [10].
In conclusion, while direct functional studies on Foxd2 from the provided references are scarce, the associated lncRNA FOXD2-AS1 clearly plays significant roles in cancer progression and other disease conditions. Understanding the functions of Foxd2 and its related molecules like FOXD2-AS1 is crucial for uncovering disease mechanisms and developing potential therapeutic strategies.
References:
1. Ghafouri-Fard, Soudeh, Harsij, Atefeh, Hussen, Bashdar Mahmud, Pourmoshtagh, Hasan, Taheri, Mohammad. 2024. A review on the role of FOXD2-AS1 in human disorders. In Pathology, research and practice, 254, 155101. doi:10.1016/j.prp.2024.155101. https://pubmed.ncbi.nlm.nih.gov/38211387/
2. Hu, Qiuhui, Tai, Sheng, Wang, Jicai. 2019. Oncogenicity of lncRNA FOXD2-AS1 and its molecular mechanisms in human cancers. In Pathology, research and practice, 215, 843-848. doi:10.1016/j.prp.2019.01.033. https://pubmed.ncbi.nlm.nih.gov/30723052/
3. Zhang, Yongping, Liang, Chaojie, Zhang, Yu, Wei, Zhigang, Guo, Jiansheng. . The role of FOXD2-AS1 in cancer: a comprehensive study based on data mining and published articles. In Bioscience reports, 40, . doi:10.1042/BSR20190372. https://pubmed.ncbi.nlm.nih.gov/33140822/
4. Zhao, Q-S, Ying, J-B, Jing, J-J, Wang, S-S. . LncRNA FOXD2-AS1 stimulates glioma progression through inhibiting P53. In European review for medical and pharmacological sciences, 24, 4382-4388. doi:10.26355/eurrev_202004_21019. https://pubmed.ncbi.nlm.nih.gov/32373975/
5. Luo, Dongbo, Salai, Adili, Lv, Hongbo, Wang, Yang, Gao, Yunfei. 2022. FOXD2-AS1 acts an oncogene in esophageal squamous cell carcinoma through sponging miR-204-3p. In Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 24, 1954-1963. doi:10.1007/s12094-022-02850-7. https://pubmed.ncbi.nlm.nih.gov/35778646/
6. Yuan, Yuan, Yu, Peng, Shen, Huihua, Xing, Guozhu, Li, Wu. 2023. LncRNA FOXD2-AS1 Increased Proliferation and Invasion of Lung Adenocarcinoma via Cell-Cycle Regulation. In Pharmacogenomics and personalized medicine, 16, 99-109. doi:10.2147/PGPM.S396866. https://pubmed.ncbi.nlm.nih.gov/36761100/
7. Katoh, Masuko, Katoh, Masaru. . Human FOX gene family (Review). In International journal of oncology, 25, 1495-500. doi:. https://pubmed.ncbi.nlm.nih.gov/15492844/
8. Liang, Yan, Wang, Hong, Song, Ruiying, Yin, Xiuyan. 2022. lncRNA FOXD2-AS1 Promotes the Retinoblastoma Cell Viability and Migration by Sponging miR-31. In BioMed research international, 2022, 7723425. doi:10.1155/2022/7723425. https://pubmed.ncbi.nlm.nih.gov/35782084/
9. Chen, G, Zhang, W-L, Zhang, S-M, Tang, K-L, Zhang, Y. . LncRNA FOXD2-AS1 facilitates the progression of hepatocellular carcinoma by regulating TWIST1. In European review for medical and pharmacological sciences, 27, 4536-4543. doi:10.26355/eurrev_202305_32460. https://pubmed.ncbi.nlm.nih.gov/37259735/
10. Wang, Yang, Cao, Lei, Wang, Qiugen, Huang, Jianhua, Xu, Shuogui. . LncRNA FOXD2-AS1 induces chondrocyte proliferation through sponging miR-27a-3p in osteoarthritis. In Artificial cells, nanomedicine, and biotechnology, 47, 1241-1247. doi:10.1080/21691401.2019.1596940. https://pubmed.ncbi.nlm.nih.gov/30945573/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen