C57BL/6JCya-Atxn1lem1/Cya
Common Name:
Atxn1l-KO
Product ID:
S-KO-17936
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Atxn1l-KO
Strain ID
KOCMP-52335-Atxn1l-B6J-VA
Gene Name
Product ID
S-KO-17936
Gene Alias
Boat; C330011L24Rik; D6Mgi37; D8Ertd587e
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
8
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Atxn1lem1/Cya mice (Catalog S-KO-17936) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000093162
NCBI RefSeq
NM_001080930
Target Region
Exon 4
Size of Effective Region
~3.4 kb
Detailed Document
Overview of Gene Research
Atxn1l, also known as ataxin 1-like, is a protein-coding gene. It interacts with CIC to form a transcription repressor complex, which is involved in regulating the expression of downstream genes, such as those in the PEA3 family (ETV1/4/5) [1]. It is also part of the ATXN1L-CIC-ETS transcription factor axis that mediates resistance to MAPK pathway inhibitors in cancer cells [2].
In some cancers, novel ATXN1L-NUTM2A fusions have been identified in aggressive infant sarcomas. These fusions may disrupt the interaction between ATXN1L and CIC, leading to overexpression of downstream PEA3 family genes. This finding may expand the scope of "CIC-rearranged" sarcomas [1]. In addition, ATXN1L deletion, which reduces CIC protein, can modulate sensitivity to the MEK1/2 inhibitor trametinib in cancer cells [2]. In coronary microembolization-induced myocardial injury, miR-142-3p can attenuate injury via the ATXN1L/HDAC3/NOL3 axis. ATXN1L promotes deacetylation of H3 through HDAC3 and thus inhibits NOL3 expression, affecting cardiomyocyte apoptosis and pyroptosis [3].
In conclusion, Atxn1l plays a crucial role in multiple biological processes, especially in the regulation of gene expression through its interaction with CIC. Its dysregulation is associated with certain cancers and myocardial injury. Studies on Atxn1l, including gene-knockout models in relevant research, help to understand the underlying molecular mechanisms of these diseases, providing potential directions for diagnosis and treatment.
References：
1. Xu, Feng, Viaene, Angela N, Ruiz, Jenny, Santi, Mariarita, Storm, Phillip B. 2022. Novel ATXN1/ATXN1L::NUTM2A fusions identified in aggressive infant sarcomas with gene expression and methylation patterns similar to CIC-rearranged sarcoma. In Acta neuropathologica communications, 10, 102. doi:10.1186/s40478-022-01401-z. https://pubmed.ncbi.nlm.nih.gov/35836290/
2. Wang, Belinda, Krall, Elsa Beyer, Aguirre, Andrew James, Root, David Edward, Hahn, William Chun. . ATXN1L, CIC, and ETS Transcription Factors Modulate Sensitivity to MAPK Pathway Inhibition. In Cell reports, 18, 1543-1557. doi:10.1016/j.celrep.2017.01.031. https://pubmed.ncbi.nlm.nih.gov/28178529/
3. Xu, Yuli, Lv, Xiangwei, Cai, Ruping, Wei, Riming, Su, Qiang. 2022. Possible implication of miR-142-3p in coronary microembolization induced myocardial injury via ATXN1L/HDAC3/NOL3 axis. In Journal of molecular medicine (Berlin, Germany), 100, 763-780. doi:10.1007/s00109-022-02198-z. https://pubmed.ncbi.nlm.nih.gov/35414011/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen