C57BL/6JCya-Ptx3em1/Cya
Common Name:
Ptx3-KO
Product ID:
S-KO-17956
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Ptx3-KO
Strain ID
KOCMP-19288-Ptx3-B6J-VB
Gene Name
Product ID
S-KO-17956
Gene Alias
TSG-14
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
3
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Ptx3em1/Cya mice (Catalog S-KO-17956) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000029421
NCBI RefSeq
NM_008987
Target Region
Exon 3
Size of Effective Region
~2.4 kb
Detailed Document
Overview of Gene Research
Ptx3, also known as long pentraxin 3, is a soluble pattern recognition molecule belonging to the humoral innate immune system [2,3,4]. It is rapidly produced at inflammatory sites by phagocytes and stromal cells in response to infection or tissue injury. Ptx3 interacts with various molecules such as microbial moieties, components of the complement and hemostatic systems, and extracellular matrix components. It plays a crucial role in innate immunity, inflammation, and tissue repair, and has been associated with multiple biological processes including neovascularization, energy metabolism, invasion, and metastasis [1,2]. Genetic models like gene-knockout (KO) mouse models have been valuable in studying Ptx3.
In Ptx3-deficient mice, there are several notable phenotypes. In the context of idiopathic pulmonary fibrosis, PTX3-deficiency was associated with worsening of the disease, impaired fibrin removal, and increased collagen deposition, suggesting a protective role of PTX3 in tissue repair [2]. In bone-related studies, Ptx3-targeted mice exhibit reduced trabecular volume during bone development and impaired callus mineralization following experimental fracture [3]. Regarding the lymphatic vasculature, Ptx3-deficient mice showed lymphatic vessel (LV) abnormalities in the colon submucosa and diaphragm, defective fluid drainage from footpads, and defective dendritic cell trafficking, indicating PTX3's role in the structural organization and immunological function of specialized LV [5].
In conclusion, Ptx3 is an essential molecule in multiple biological processes. Model-based research, especially using Ptx3 KO mouse models, has revealed its roles in diseases such as idiopathic pulmonary fibrosis, bone-related pathologies, and lymphatic-associated disorders. These findings contribute to our understanding of the underlying mechanisms of these diseases and may potentially lead to new therapeutic strategies targeting Ptx3.
References:
1. Li, Duo, Hao, Zhaozhao, Nan, Yandong, Chen, Yanwei. 2023. Role of long pentraxin PTX3 in cancer. In Clinical and experimental medicine, 23, 4401-4411. doi:10.1007/s10238-023-01137-7. https://pubmed.ncbi.nlm.nih.gov/37438568/
2. Doni, Andrea, Mantovani, Alberto, Bottazzi, Barbara, Russo, Remo Castro. 2021. PTX3 Regulation of Inflammation, Hemostatic Response, Tissue Repair, and Resolution of Fibrosis Favors a Role in Limiting Idiopathic Pulmonary Fibrosis. In Frontiers in immunology, 12, 676702. doi:10.3389/fimmu.2021.676702. https://pubmed.ncbi.nlm.nih.gov/34276664/
3. Parente, Raffaella, Sobacchi, Cristina, Bottazzi, Barbara, Grčevic, Danka, Inforzato, Antonio. 2019. The Long Pentraxin PTX3 in Bone Homeostasis and Pathology. In Frontiers in immunology, 10, 2628. doi:10.3389/fimmu.2019.02628. https://pubmed.ncbi.nlm.nih.gov/31787987/
4. Tarantino, Umberto, Greggi, Chiara, Cariati, Ida, Salustri, Antonietta, Scimeca, Manuel. 2021. The Role of PTX3 in Mineralization Processes and Aging-Related Bone Diseases. In Frontiers in immunology, 11, 622772. doi:10.3389/fimmu.2020.622772. https://pubmed.ncbi.nlm.nih.gov/33584725/
5. Doni, Andrea, Sironi, Marina, Del Prete, Annalisa, Bottazzi, Barbara, Mantovani, Alberto. 2024. PTX3 is expressed in terminal lymphatics and shapes their organization and function. In Frontiers in immunology, 15, 1426869. doi:10.3389/fimmu.2024.1426869. https://pubmed.ncbi.nlm.nih.gov/39640269/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen