C57BL/6JCya-Hdac7em1/Cya
Common Name:
Hdac7-KO
Product ID:
S-KO-17964
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Hdac7-KO
Strain ID
KOCMP-56233-Hdac7-B6J-VA
Gene Name
Product ID
S-KO-17964
Gene Alias
5830434K02Rik; HD7; HD7a; Hdac7a; mFLJ00062
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
15
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Hdac7em1/Cya mice (Catalog S-KO-17964) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000116409
NCBI RefSeq
NM_001204275
Target Region
Exon 5~11
Size of Effective Region
~3.3 kb
Detailed Document
Overview of Gene Research
HDAC7, a member of the histone deacetylase family, is a "pseudodeacetylase" due to a mutation of a catalytic tyrosine, with its deacetylase-related activities attributed to scaffolding functions [6]. It can participate in multiple cellular pathophysiological processes by exerting deacetylation, and is involved in regulating gene transcription by compacting chromatin as histone deacetylases target histones [2]. HDAC7 is associated with various signaling pathways including β-catenin, PI3K/AKT/mTOR, IKK/NF-κB, and is crucial in processes like cell proliferation, metastasis, and immune responses [1,3,4,8].
In NSCLC, overexpression of HDAC7 promotes cell proliferation and metastasis by upregulating FGF18 via the β-catenin-FGF18 pathway, and deubiquitinase USP10 stabilizes HDAC7 [1]. In ESCC, HDAC7 forms a positive feedback loop with β-catenin and c-Myc to enhance cell growth, and USP10 maintains HDAC7 protein stability [3]. In ovarian cancer, HDAC7 promotes malignancy through the AKT/mTOR signaling pathway [4]. In choroidal melanoma, the HDAC7/c-Myc signaling pathway promotes cell proliferation and metastasis [5]. In glioblastoma, HDAC7 drives the tumor to a mesenchymal-like state via LGALS3-mediated crosstalk between cancer cells and macrophages [7]. In astrocytes, HDAC7 activates the IKK/NF-κB signaling pathway to regulate inflammation [8].
In conclusion, HDAC7 plays essential roles in multiple biological processes and is significantly involved in the development of various cancers and inflammation-related diseases. Studies using different models, though not specifically KO/CKO mouse models in the provided references, have revealed its functions in disease-associated pathways, highlighting its potential as a prognostic biomarker and therapeutic target in these disease areas.
References:
1. Guo, Kai, Ma, Zhiqiang, Zhang, Yujiao, Li, Xiaofei, Yan, Xiaolong. 2022. HDAC7 promotes NSCLC proliferation and metastasis via stabilization by deubiquitinase USP10 and activation of β-catenin-FGF18 pathway. In Journal of experimental & clinical cancer research : CR, 41, 91. doi:10.1186/s13046-022-02266-9. https://pubmed.ncbi.nlm.nih.gov/35277183/
2. Liu, Cui, Zheng, Dan, Pu, Xuan, Li, Sijun. 2024. HDAC7: a promising target in cancer. In Frontiers in oncology, 14, 1327933. doi:10.3389/fonc.2024.1327933. https://pubmed.ncbi.nlm.nih.gov/38487728/
3. Ma, Zhi-Qiang, Feng, Ying-Tong, Guo, Kai, Yan, Xiao-Long, Hu, Yi. 2022. Melatonin inhibits ESCC tumor growth by mitigating the HDAC7/β-catenin/c-Myc positive feedback loop and suppressing the USP10-maintained HDAC7 protein stability. In Military Medical Research, 9, 54. doi:10.1186/s40779-022-00412-0. https://pubmed.ncbi.nlm.nih.gov/36163081/
4. Feng, Qi, Hao, Sheng, Liu, Xiongxiu, Zhang, Peng, Sheng, Xiugui. . HDAC7 promotes ovarian cancer malignancy via AKT/mTOR signalling pathway. In Journal of cellular and molecular medicine, 28, e70120. doi:10.1111/jcmm.70120. https://pubmed.ncbi.nlm.nih.gov/39431349/
5. Zhang, Yimeng, Ding, Peng, Wang, Yuanyong, Ma, Zhiqiang, Han, Jing. 2023. HDAC7/c-Myc signaling pathway promotes the proliferation and metastasis of choroidal melanoma cells. In Cell death & disease, 14, 38. doi:10.1038/s41419-022-05522-0. https://pubmed.ncbi.nlm.nih.gov/36653340/
6. Kodikara, Ishadi K M, Pflum, Mary Kay H. 2025. Scaffolding Activities of Pseudodeacetylase HDAC7. In ACS chemical biology, 20, 248-258. doi:10.1021/acschembio.4c00753. https://pubmed.ncbi.nlm.nih.gov/39908122/
7. Zhao, Shulin, Zhao, Rongrong, Wang, Chuanzheng, Deng, Lin, Li, Gang. 2024. HDAC7 drives glioblastoma to a mesenchymal-like state via LGALS3-mediated crosstalk between cancer cells and macrophages. In Theranostics, 14, 7072-7087. doi:10.7150/thno.100939. https://pubmed.ncbi.nlm.nih.gov/39629136/
8. Ye, Jinwang, Zhong, Suyue, Deng, Yunsong, Wang, Jian-Zhi, Xiao, Shifeng. 2022. HDAC7 Activates IKK/NF-κB Signaling to Regulate Astrocyte-Mediated Inflammation. In Molecular neurobiology, 59, 6141-6157. doi:10.1007/s12035-022-02965-6. https://pubmed.ncbi.nlm.nih.gov/35871708/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen