C57BL/6JCya-Sycp2lem1/Cya
Common Name:
Sycp2l-KO
Product ID:
S-KO-17967
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Sycp2l-KO
Strain ID
KOCMP-637277-Sycp2l-B6J-VB
Gene Name
Product ID
S-KO-17967
Gene Alias
EG621792; Gm268; Gm40956
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
13
Phenotype
Document
Application
--
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Sycp2lem1/Cya mice (Catalog S-KO-17967) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000124093
NCBI RefSeq
NM_001324525
Target Region
Exon 8~14
Size of Effective Region
~11.5 kb
Detailed Document
Overview of Gene Research
SYCP2L, a paralogue of the synaptonemal complex protein SYCP2, is expressed exclusively in oocytes. It localizes to centromeres of dictyate stage oocytes and promotes the survival of primordial oocytes, thus being important for female reproductive function [3]. It may also be involved in pathways related to ovarian function and egg production [3,4]. Genetic mouse models have been valuable in studying SYCP2L.
Female mice lacking SYCP2L experience a significantly higher progressive loss of oocytes with age compared to wild-type females, leading to reduced fertility. The pool of primordial oocytes depletes more rapidly in SYCP2L-deficient females, resulting in fewer oocytes maturing in developing follicles [3]. In humans, homozygous variants in SYCP2L have been found to cause premature ovarian insufficiency (POI), with mutant SYCP2L proteins showing mislocalization and loss of function [1]. Additionally, single-nucleotide polymorphisms (SNPs) in SYCP2L are associated with ovarian reserve markers such as anti-Müllerian hormone (AMH) levels and reproductive outcomes in women undergoing in vitro fertilization (IVF) treatment [2,5].
In conclusion, SYCP2L is crucial for female reproductive function, especially in maintaining the survival of primordial oocytes. Studies on SYCP2L-deficient mouse models have provided functional evidence of its role in female reproduction, and human genetic studies have further linked it to POI and other reproductive-related phenotypes. Understanding SYCP2L can potentially lead to better diagnosis and treatment strategies for female infertility.
References:
1. He, Wen-Bin, Tan, Chen, Zhang, Ya-Xin, Du, Juan, Tan, Yue-Qiu. 2020. Homozygous variants in SYCP2L cause premature ovarian insufficiency. In Journal of medical genetics, 58, 168-172. doi:10.1136/jmedgenet-2019-106789. https://pubmed.ncbi.nlm.nih.gov/32303603/
2. Rosa, Iasmim Ribeiro, Barbosa, Caio Parente, Ferrandez, Caroline Awoki, Peluso, Carla, Bianco, Bianca. 2023. Involvement of SYCP2L and TDRD3 gene variants on ovarian reserve and reproductive outcomes: a cross-sectional study. In JBRA assisted reproduction, 27, 428-435. doi:10.5935/1518-0557.20220074. https://pubmed.ncbi.nlm.nih.gov/37417852/
3. Zhou, Jian, Stein, Paula, Leu, N Adrian, Schultz, Richard M, Wang, P Jeremy. 2015. Accelerated reproductive aging in females lacking a novel centromere protein SYCP2L. In Human molecular genetics, 24, 6505-14. doi:10.1093/hmg/ddv359. https://pubmed.ncbi.nlm.nih.gov/26362258/
4. Bhavana, Karippadakam, Foote, Dustin J, Srikanth, Krishnamoorthy, Gopalakrishnan, Achamveetil, Nagarajan, Muniyandi. 2022. Comparative transcriptome analysis of Indian domestic duck reveals candidate genes associated with egg production. In Scientific reports, 12, 10943. doi:10.1038/s41598-022-15099-5. https://pubmed.ncbi.nlm.nih.gov/35768515/
5. Laisk-Podar, Triin, Kaart, Tanel, Peters, Maire, Salumets, Andres. 2015. Genetic variants associated with female reproductive ageing--potential markers for assessing ovarian function and ovarian stimulation outcome. In Reproductive biomedicine online, 31, 199-209. doi:10.1016/j.rbmo.2015.05.001. https://pubmed.ncbi.nlm.nih.gov/26099445/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen