C57BL/6JCya-Tdrpem1/Cya
Common Name:
Tdrp-KO
Product ID:
S-KO-17971
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Tdrp-KO
Strain ID
KOCMP-72148-Tdrp-B6J-VB
Gene Name
Product ID
S-KO-17971
Gene Alias
2610019F03Rik
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
8
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Tdrpem1/Cya mice (Catalog S-KO-17971) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000062613
NCBI RefSeq
NM_173744.4
Target Region
Exon 2~3
Size of Effective Region
~4.9 kb
Detailed Document
Overview of Gene Research
Tdrp, or Testis Development-Related Protein, is a nuclear factor potentially playing a crucial role in spermatogenesis. It might be involved in molecular mechanisms underlying this fundamental reproductive process. Genetic models, such as mouse models, are valuable for studying Tdrp's function.
In a Tdrp -deficient mouse model study [1], Tdrp -deficient mice showed no significant differences from wild-type littermates in testes and genitourinary tract development or sperm count. However, several sperm motility indexes like average path velocity (VAP), straight line velocity (VSL), and curvilinear velocity (VCL) were significantly decreased (p<0.05). The proportion of slow-velocity sperm also increased significantly (p<0.05). Fertility tests, though, showed no significant difference in average offspring amount (AOA), frequency of copulatory plug (FCP), and frequency of conception (FC). Additionally, TDRP1 could interact with PRM2, which might be the molecular mechanism of its nuclear function in spermatozoa.
In conclusion, Tdrp plays a role in sperm motility, as shown through the Tdrp -deficient mouse model. Although Tdrp deficiency alone was not sufficient to cause male infertility in mice, its role in sperm motility indicates its importance in male reproductive biology [1]. Also, genes TDRP, along with MC2R, FBXO25 and FBXL21, were found to be associated with longevity in Cane corso dogs, suggesting a potential role in the aging process [2].
References:
1. Mao, Shanhua, Wu, Fei, Cao, Xinyi, Ding, Qiang, Wang, Xuanchun. 2016. TDRP deficiency contributes to low sperm motility and is a potential risk factor for male infertility. In American journal of translational research, 8, 177-87. doi:. https://pubmed.ncbi.nlm.nih.gov/27069551/
2. Korec, Evžen, Ungrová, Lenka, Hejnar, Jiří, Grieblová, Adéla. 2022. Four novel genes associated with longevity found in Cane corso purebred dogs. In BMC veterinary research, 18, 188. doi:10.1186/s12917-022-03290-9. https://pubmed.ncbi.nlm.nih.gov/35590325/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen