C57BL/6JCya-Cebpzem1/Cya
Common Name:
Cebpz-KO
Product ID:
S-KO-17977
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Cebpz-KO
Strain ID
KOCMP-12607-Cebpz-B6J-VB
Gene Name
Product ID
S-KO-17977
Gene Alias
CBF2; Cbf
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
17
Phenotype
Document
Application
--
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Cebpzem1/Cya mice (Catalog S-KO-17977) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000024885
NCBI RefSeq
NM_001024806
Target Region
Exon 3~4
Size of Effective Region
~1.0 kb
Detailed Document
Overview of Gene Research
Cebpz, also known as CCAAT/enhancer binding protein zeta, is a transcription factor that plays crucial roles in various biological processes. It is involved in ribosomal RNA (rRNA) processing, with its functions in this regard being conserved in vertebrates [5]. It may also contribute to important regulatory pathways in energy metabolism and immune regulation, as indicated by its identification as a hub gene in the context of epicardial adipose tissue's role in the relationship between type 2 diabetes mellitus and atrial fibrillation [4]. Additionally, it has been associated with pathways related to leukaemia, adipogenic differentiation, and melanoma cell death [1,2,3].
In glucocorticoid-associated osteonecrosis of the femoral head, exosomal miR-1a-3p from glucocorticoid-stimulated M1 macrophages promotes the adipogenic differentiation of bone marrow mesenchymal stem cells by targeting Cebpz [2]. In melanoma, PIKFYVE inhibitors upregulate interleukin-24 (IL24) through the DDIT3/CHOP/CEBPz transcription factor, leading to melanoma cell death [3].
In conclusion, Cebpz is involved in diverse biological processes such as rRNA processing, energy metabolism, and immune regulation. Studies, like those in the context of glucocorticoid-associated osteonecrosis of the femoral head and melanoma, using relevant models have revealed its role in disease-related processes. These findings contribute to our understanding of the biological functions of Cebpz and its potential as a therapeutic target in certain diseases.
References:
1. Barbieri, Isaia, Tzelepis, Konstantinos, Pandolfini, Luca, Vassiliou, George S, Kouzarides, Tony. 2017. Promoter-bound METTL3 maintains myeloid leukaemia by m6A-dependent translation control. In Nature, 552, 126-131. doi:10.1038/nature24678. https://pubmed.ncbi.nlm.nih.gov/29186125/
2. Duan, Ping, Yu, Yong-Le, Cheng, Yan-Nan, Ji, Yan-Xiao, Pan, Zhen-Yu. 2024. Exosomal miR-1a-3p derived from glucocorticoid-stimulated M1 macrophages promotes the adipogenic differentiation of BMSCs in glucocorticoid-associated osteonecrosis of the femoral head by targeting Cebpz. In Journal of nanobiotechnology, 22, 648. doi:10.1186/s12951-024-02923-5. https://pubmed.ncbi.nlm.nih.gov/39438865/
3. Roy, Ajit, Chakraborty, Arup R, DePamphilis, Melvin L. 2024. PIKFYVE inhibitors trigger interleukin-24-dependent cell death of autophagy-dependent melanoma. In Molecular oncology, 18, 988-1011. doi:10.1002/1878-0261.13607. https://pubmed.ncbi.nlm.nih.gov/38414326/
4. Li, Tian-Lun, Zhu, Na-Na, Yin, Zhao, Li, Shi-Xing, Shan, Zhao-Liang. 2024. Transcriptomic analysis of epicardial adipose tissue reveals the potential crosstalk genes and immune relationship between type 2 diabetes mellitus and atrial fibrillation. In Gene, 920, 148528. doi:10.1016/j.gene.2024.148528. https://pubmed.ncbi.nlm.nih.gov/38703871/
5. Rambaldelli, Guglielmo, Manara, Valeria, Vutera Cuda, Andrea, Penzo, Marianna, Bellosta, Paola. 2025. From Flies to Humans: Conserved Roles of CEBPZ, NOC2L, and NOC3L in rRNA Processing and Tumorigenesis. In bioRxiv : the preprint server for biology, , . doi:10.1101/2025.01.11.632529. https://pubmed.ncbi.nlm.nih.gov/39868138/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen