C57BL/6JCya-Ahrrem1/Cya
Common Name
Ahrr-KO
Product ID
S-KO-17982
Backgroud
C57BL/6JCya
Strain ID
KOCMP-11624-Ahrr-B6J-VA
When using this mouse strain in a publication, please cite “Ahrr-KO Mouse (Catalog S-KO-17982) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Ahrr-KO
Strain ID
KOCMP-11624-Ahrr-B6J-VA
Gene Name
Product ID
S-KO-17982
Gene Alias
mKIAA1234
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 13
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000022059
NCBI RefSeq
NM_009644
Target Region
Exon 6
Size of Effective Region
~1.6 kb
Overview of Gene Research
Ahrr, short for Aryl-Hydrocarbon Receptor Repressor, is a key gene involved in regulating the aryl-hydrocarbon receptor (AHR) pathway. AHR is a ligand-activated transcription factor, and Ahrr acts as its negative regulator. It is important in various biological processes such as cellular growth, differentiation, and regulation of cellular toxicity. Ahrr is also associated with carcinogenesis and immune-related functions [1,2].
In head and neck cancer, Ahrr-null (Ahrr-/ -) mice showed reduced tumor development frequency compared to Ahrr wild-type (Ahrr + / +) transgenic mice. This indicates that Ahrr contributes to inflammatory lymphangiogenesis by activating the EPAS1/VEGFD signaling axis in head and neck cancer [3]. In intestinal intraepithelial lymphocytes (IELs), Ahrr deficiency led to reduced IEL representation, increased oxidative stress, lipid peroxidation, and ferroptosis. Dietary supplementation with selenium or vitamin E rescued Ahrr-/-IELs, and loss of IELs in Ahrr-/-mice caused susceptibility to Clostridium difficile infection and dextran sodium-sulfate-induced colitis [2].
In conclusion, Ahrr plays crucial roles in multiple biological processes. Through gene-knockout mouse models, its functions in lymphangiogenesis in head and neck cancer and in maintaining intestinal immune responses have been revealed. Understanding Ahrr's functions provides insights into the mechanisms of related diseases and may offer potential targets for disease treatment and prevention.
References：
1. Linnenkamp, Bianca Domit Werner, Raskin, Salmo, Esposito, Selene Elifio, Herai, Roberto Hirochi. 2020. A comprehensive analysis of AHRR gene as a candidate for cleft lip with or without cleft palate. In Mutation research. Reviews in mutation research, 785, 108319. doi:10.1016/j.mrrev.2020.108319. https://pubmed.ncbi.nlm.nih.gov/32800270/
2. Panda, Santosh K, Peng, Vincent, Sudan, Raki, Cella, Marina, Colonna, Marco. 2023. Repression of the aryl-hydrocarbon receptor prevents oxidative stress and ferroptosis of intestinal intraepithelial lymphocytes. In Immunity, 56, 797-812.e4. doi:10.1016/j.immuni.2023.01.023. https://pubmed.ncbi.nlm.nih.gov/36801011/
3. Hu, An, Zhang, Jian-Wei, Yang, Li-Yun, Qiao, Pei-Pei, Lu, Dan. 2022. AHRR contributes to inflammatory lymphangiogenesis by activating the EPAS1/VEGFD signaling axis in head and neck cancer. In American journal of cancer research, 12, 537-548. doi:. https://pubmed.ncbi.nlm.nih.gov/35261785/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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