C57BL/6JCya-Vnn3em1/Cya
Common Name
Vnn3-KO
Product ID
S-KO-18056
Backgroud
C57BL/6JCya
Strain ID
KOCMP-26464-Vnn3-B6J-VB
When using this mouse strain in a publication, please cite “Vnn3-KO Mouse (Catalog S-KO-18056) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Vnn3-KO
Strain ID
KOCMP-26464-Vnn3-B6J-VB
Gene Name
Product ID
S-KO-18056
Gene Alias
--
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 10
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000020190
NCBI RefSeq
NM_011979
Target Region
Exon 3
Size of Effective Region
~0.2 kb
Overview of Gene Research
Vnn3, also known as vanin-3, is a member of the pantetheinase gene family. Pantetheinase enzymes hydrolyze pantetheine into pantothenic acid and cysteamine, with cysteamine being a key regulator of host responses to inflammatory stimuli [4,5].
Vnn3 has been associated with multiple disease conditions. In clear cell renal cell carcinoma (ccRCC), high Vnn3 expression is linked to poor prognoses, making it a potential biomarker for predicting ccRCC prognosis [1]. In benzene-exposed workers, Vnn3 expression is correlated with hemogram and influences cell proliferation induced by 1,4-benzoquinone, a benzene metabolite, by regulating KLF15 and NOTCH1 expression, suggesting it could be a biomarker of benzene toxicity [2]. In heart failure, Vnn3 is one of the four identified diagnostic markers associated with neutrophil extracellular traps (NETs), enhancing the understanding of immunology in heart failure [3]. Mice defective in Vnn3 show increased susceptibility to blood-stage malaria, and supplementation with cysteamine corrects part of the malaria-susceptibility phenotype, indicating Vnn3's role in host response to malaria [6]. In chronic heart failure patients, Vnn3 is independently associated with an elevated neutrophil-to-lymphocyte ratio (NLR), which may help in prognosis prediction [7].
In conclusion, Vnn3 is involved in various biological processes related to disease, such as cancer prognosis, response to chemical toxicity, immunology in heart failure, and host response to malaria. Studies on Vnn3-deficient mouse models have provided valuable insights into its role in these disease areas, contributing to a better understanding of disease mechanisms and potential biomarker discovery.
References：
1. Ha, Mihyang, Jeong, Hoim, Roh, Jong Seong, Sohn, Dong Hyun, Kim, Yun Hak. 2019. VNN3 is a potential novel biomarker for predicting prognosis in clear cell renal cell carcinoma. In Animal cells and systems, 23, 112-117. doi:10.1080/19768354.2019.1583126. https://pubmed.ncbi.nlm.nih.gov/30949398/
2. Sun, Pengling, Guo, Xiaoli, Chen, Yujiao, Duan, Huawei, Gao, Ai. 2017. VNN3, a potential novel biomarker for benzene toxicity, is involved in 1, 4-benzoquinone induced cell proliferation. In Environmental pollution (Barking, Essex : 1987), 233, 323-330. doi:10.1016/j.envpol.2017.10.087. https://pubmed.ncbi.nlm.nih.gov/29096305/
3. Li, Xudong, Xu, Changhao, Li, Qiaoqiao, Shen, Qingxiang, Zeng, Long. 2023. Exploring key genes associated with neutrophil function and neutrophil extracellular traps in heart failure: a comprehensive analysis of single-cell and bulk sequencing data. In Frontiers in cell and developmental biology, 11, 1258959. doi:10.3389/fcell.2023.1258959. https://pubmed.ncbi.nlm.nih.gov/37941896/
4. Nitto, Takeaki, Inoue, Teruo, Node, Koichi. 2008. Alternative spliced variants in the pantetheinase family of genes expressed in human neutrophils. In Gene, 426, 57-64. doi:10.1016/j.gene.2008.08.019. https://pubmed.ncbi.nlm.nih.gov/18805469/
5. Min-Oo, Gundula, Fortin, Anny, Pitari, Giuseppina, Stevenson, Mary M, Gros, Philippe. 2007. Complex genetic control of susceptibility to malaria: positional cloning of the Char9 locus. In The Journal of experimental medicine, 204, 511-24. doi:. https://pubmed.ncbi.nlm.nih.gov/17312006/
6. Moradin, Neda, Torre, Sabrina, Gauthier, Susan, Stevenson, Mary M, Gros, Philippe. 2016. Cysteamine broadly improves the anti-plasmodial activity of artemisinins against murine blood stage and cerebral malaria. In Malaria journal, 15, 260. doi:10.1186/s12936-016-1317-3. https://pubmed.ncbi.nlm.nih.gov/27150250/
7. Wan, Guoxing, Ji, Lihua, Xia, Wenbin, Cheng, Lan, Zhang, Yonggang. 2018. Screening genes associated with elevated neutrophil‑to‑lymphocyte ratio in chronic heart failure. In Molecular medicine reports, 18, 1415-1422. doi:10.3892/mmr.2018.9132. https://pubmed.ncbi.nlm.nih.gov/29901123/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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