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C57BL/6JCya-Rbm14em1/Cya
Common Name:
Rbm14-KO
Product ID:
S-KO-18072
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Rbm14-KO
Strain ID
KOCMP-56275-Rbm14-B6J-VB
Gene Name
Rbm14
Product ID
S-KO-18072
Gene Alias
1300007E16Rik; PSP2; Sytip; p16; p16K
Background
C57BL/6JCya
NCBI ID
56275
Modification
Conventional knockout
Chromosome
19
Phenotype
MGI:1929092
Document
Click here to download >>
Application
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Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Rbm14em1/Cya mice (Catalog S-KO-18072) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000006625
NCBI RefSeq
NM_019869.3
Target Region
Exon 2
Size of Effective Region
~1.9 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Rbm14, an RNA-binding protein, is involved in multiple essential biological functions. It plays roles in DNA repair pathways such as homologous recombination repair and canonical nonhomologous end-joining. It is also associated with cell cycle regulation, oocyte meiotic maturation, and embryonic development. Additionally, it has been implicated in various disease-related processes like cancer development and virus-host interactions [2,5-10].

In knockout studies, Rbm14 knockout in mice leads to apoptosis and cell proliferation defects in early post-implantation epiblast cells, resulting in gastrulation disruption and embryonic lethality. This indicates its crucial role in maintaining genome integrity during early mouse embryogenesis through mediating alternative splicing of DNA damage response-related genes [1]. In mouse embryonic stem cells, depletion of Rbm14 alters gene expression profiles, downregulating pluripotency-associated genes and those in the Wnt and TGF-β signaling pathways, and it is essential for mesoderm development [2]. In zebrafish and mouse, depletion of Rbm14 impairs embryonic cell differentiations and full activations of the zygotic genome, causing developmental arrest at the blastula stage [3].

In conclusion, Rbm14 is vital for maintaining genome integrity, pluripotency, and early embryonic development. Its knockout models have revealed its significance in these processes. In the context of diseases, Rbm14 has been linked to cancer and virus-related conditions, highlighting its potential as a therapeutic target in these areas.

References:
1. Li, Jing, Wang, Chenxin, Feng, Guihai, Zhou, Qi, Li, Wei. 2019. Rbm14 maintains the integrity of genomic DNA during early mouse embryogenesis via mediating alternative splicing. In Cell proliferation, 53, e12724. doi:10.1111/cpr.12724. https://pubmed.ncbi.nlm.nih.gov/31794640/
2. Chen, Guilai, Zhang, Da, Zhang, Linlin, Zhang, Ying, Hu, Baoyang. 2018. RBM14 is indispensable for pluripotency maintenance and mesoderm development of mouse embryonic stem cells. In Biochemical and biophysical research communications, 501, 259-265. doi:10.1016/j.bbrc.2018.04.231. https://pubmed.ncbi.nlm.nih.gov/29729270/
3. Xiao, Yue, Chen, Jiehui, Yang, Suming, Jing, Naihe, Zhu, Xueliang. 2022. Maternal mRNA deadenylation and allocation via Rbm14 condensates facilitate vertebrate blastula development. In The EMBO journal, 42, e111364. doi:10.15252/embj.2022111364. https://pubmed.ncbi.nlm.nih.gov/36477743/
Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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