C57BL/6JCya-Apomem1/Cya
Common Name
Apom-KO
Product ID
S-KO-18078
Backgroud
C57BL/6JCya
Strain ID
KOCMP-55938-Apom-B6J-VB
When using this mouse strain in a publication, please cite “Apom-KO Mouse (Catalog S-KO-18078) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Apom-KO
Strain ID
KOCMP-55938-Apom-B6J-VB
Gene Name
Product ID
S-KO-18078
Gene Alias
1190010O19Rik, G3a, NG20
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 17
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000025249
NCBI RefSeq
NM_018816
Target Region
Exon 1~5
Size of Effective Region
~2.0 kb
Overview of Gene Research
ApoM, short for apolipoprotein M, is a member of the apolipoprotein family. It is primarily expressed and secreted from the liver and kidneys. ApoM is the main chaperone of sphingosine-1-phosphate (S1P), a small signalling molecule involved in numerous physiologic and pathophysiologic processes. It is also associated with lipid metabolism, and 95% of plasma ApoM is found associated with high-density lipoproteins (HDL) [1,2,3].
ApoM-deficient mice display an increased activity in brown adipose tissue and a concomitant fast turnover of triglycerides, suggesting that the ApoM/S1P axis plays a significant role in maintaining a balanced triglyceride metabolism [4]. In addition, in a female human ApoM transgenic mouse model with increased plasma ApoM and S1P levels, there was a reduced plasma triglyceride turnover rate and lower free fatty acid uptake in subcutaneous adipocytes [4].
In conclusion, ApoM is essential for transporting S1P and is involved in lipid metabolism. Mouse models, such as ApoM-deficient and ApoM transgenic mice, have revealed its role in triglyceride metabolism. Understanding ApoM's function can potentially provide new insights into the treatment of diseases related to lipid metabolism disorders [4].
References：
1. Chen, Zhiyang, Hu, Min. 2020. The apoM-S1P axis in hepatic diseases. In Clinica chimica acta; international journal of clinical chemistry, 511, 235-242. doi:10.1016/j.cca.2020.10.023. https://pubmed.ncbi.nlm.nih.gov/33096030/
2. Bisgaard, Line S, Christoffersen, Christina. 2021. The apoM/S1P Complex-A Mediator in Kidney Biology and Disease? In Frontiers in medicine, 8, 754490. doi:10.3389/fmed.2021.754490. https://pubmed.ncbi.nlm.nih.gov/34722589/
3. Mousa, Hanaa, Thanassoulas, Angelos, Zughaier, Susu M. 2023. ApoM binds endotoxin contributing to neutralization and clearance by High Density Lipoprotein. In Biochemistry and biophysics reports, 34, 101445. doi:10.1016/j.bbrep.2023.101445. https://pubmed.ncbi.nlm.nih.gov/36915826/
4. Hajny, Stefan, Borup, Anna, Elsøe, Sara, Christoffersen, Christina. 2021. Increased plasma apoM levels impair triglyceride turnover in mice. In Biochimica et biophysica acta. Molecular and cell biology of lipids, 1866, 158969. doi:10.1016/j.bbalip.2021.158969. https://pubmed.ncbi.nlm.nih.gov/34051379/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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