C57BL/6JCya-Nicn1em1/Cya
Common Name
Nicn1-KO
Product ID
S-KO-18097
Backgroud
C57BL/6JCya
Strain ID
KOCMP-66257-Nicn1-B6J-VB
Status
When using this mouse strain in a publication, please cite “Nicn1-KO Mouse (Catalog S-KO-18097) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
The standard delivery applies for a guaranteed minimum of three heterozygous carriers. Breeding services for homozygous carriers and/or specified sex are available.
Basic Information
Strain Name
Nicn1-KO
Strain ID
KOCMP-66257-Nicn1-B6J-VB
Gene Name
Product ID
S-KO-18097
Gene Alias
p24, PGs5, 1500032A17Rik
Background
C57BL/6JCya
Gene Full Name
nicolin 1
Modification
Conventional knockout
NCBI ID
Phenotype
Chromosome
Chr 9 (Mouse)
Application
--
Datasheet
Strain Description
Ensembl Transcript ID
ENSMUST00000035227
NCBI Transcript ID
NM_025449
Target Region
Exon 2~6
Size of Effective Region
~4.3 kb
Overview of Gene Research
Nicn1, also known as nicolin 1 gene, encodes a 213-amino-acid, 24 kDa nuclear protein [2]. It is mammalian-specific and consists of six exons spanning about 6 kb of genomic DNA [2]. The gene is expressed in a tissue-specific manner, with high expression in brain, testis, liver, and kidney [2]. Although its exact function remains to be fully elucidated, eQTL analysis shows associations between Nicn1 and SNPs in subcutaneous and visceral adipose tissues, and it is involved in biological pathways such as cortisol synthesis, thyroid hormone synthesis, and insulin secretion, which are related to obesity-associated sedentary behaviors [1].
In addition, Nicn1 has been identified as a host gene promoting HIV-1 latency. shRNA knockdown of Nicn1 significantly enhances HIV expression in primary CD4 T cells, suggesting that downregulation of Nicn1 stimulates RNA Polymerase II-mediated transcription of HIV-1 [3]. Also, in lung cancer studies, Nicn1 shows a strong correlation with FHIT expression in both LUAD and LUSC, indicating its potential role in lung cancer-related gene regulatory networks [4].
In conclusion, Nicn1 is a mammalian-specific gene with tissue-specific expression. Its involvement in multiple biological pathways related to obesity-associated sedentary behaviors, as well as its role in promoting HIV-1 latency and in lung cancer-related gene regulation, highlights its importance in various physiological and disease-related processes. Research on Nicn1 using genetic models can potentially provide further insights into these biological functions and disease mechanisms.
References：
1. Chen, Siqing, Yang, Lili, Yang, Yuting, Wang, Chenchen, Ye, Jing. 2024. Sedentary behavior, physical activity, sleep duration and obesity risk: Mendelian randomization study. In PloS one, 19, e0300074. doi:10.1371/journal.pone.0300074. https://pubmed.ncbi.nlm.nih.gov/38457382/
2. Backofen, Bianca, Jacob, Ralf, Serth, Katrin, Naim, Hassan Y, Leeb, Tosso. . Cloning and characterization of the mammalian-specific nicolin 1 gene (NICN1) encoding a nuclear 24 kDa protein. In European journal of biochemistry, 269, 5240-5. doi:. https://pubmed.ncbi.nlm.nih.gov/12392556/
3. Li, Zichong, Hajian, Cyrus, Greene, Warner C. 2020. Identification of unrecognized host factors promoting HIV-1 latency. In PLoS pathogens, 16, e1009055. doi:10.1371/journal.ppat.1009055. https://pubmed.ncbi.nlm.nih.gov/33270809/
4. Situ, Yongli, Gao, Ruxiu, Lei, Lei, Xu, Qinying, Shao, Zheng. 2022. System analysis of FHIT in LUAD and LUSC: The expression, prognosis, gene regulation network, and regulation targets. In The International journal of biological markers, 37, 158-169. doi:10.1177/03936155221084056. https://pubmed.ncbi.nlm.nih.gov/35254116/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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