C57BL/6JCya-Rab11fip3em1/Cya
Common Name
Rab11fip3-KO
Product ID
S-KO-18121
Backgroud
C57BL/6JCya
Strain ID
KOCMP-215445-Rab11fip3-B6J-VB
When using this mouse strain in a publication, please cite “Rab11fip3-KO Mouse (Catalog S-KO-18121) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Rab11fip3-KO
Strain ID
KOCMP-215445-Rab11fip3-B6J-VB
Gene Name
Product ID
S-KO-18121
Gene Alias
Cart1, D030060O14Rik, Rab11-FIP3, mKIAA0665
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 17
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000122103
NCBI RefSeq
NM_001162869
Target Region
Exon 1~9
Size of Effective Region
~71.6 kb
Overview of Gene Research
Rab11fip3, also known as RAB11 family-interacting protein 3, is involved in endocytosis and endocytic recycling pathways [4]. It associates with recycling endosomes, playing a role in trafficking vesicles, which is crucial for maintaining cellular homeostasis and proper function of various cell-related processes [5].
In gastric cancer, the IKZF4/NONO-RAB11FIP3 axis promotes immune evasion by facilitating PD-L1 endosome recycling. Silencing of RAB11FIP3 promotes T-cell proliferation and cytotoxicity towards gastric cancer cells, inhibits tumor immune evasion in mice by increasing CD8+ T-cell infiltration into the tumor microenvironment [1].
In breast cancer, RAB11FIP3 combines with Eps15 homology domain 1 to promote the endocytosis recycling of phosphorylated epithelial growth factor receptor, regulating breast cancer progression [2].
In papillary thyroid cancer, RAB11FIP3, along with other key proteins in endocytotic recycling, promotes tumorigenesis through the regulation of epidermal growth factor receptor transport [3].
In conclusion, Rab11fip3 has significant functions in endocytic recycling processes. Its role in diseases such as gastric, breast, and papillary thyroid cancers has been revealed through functional studies. Understanding the functions of Rab11fip3 in these disease models can provide potential therapeutic targets for these cancers.
References：
1. Weng, Nuoqing, Zhou, Chuzhou, Zhou, Yuhang, Wang, Huiyun, Wu, Xiaobin. 2024. IKZF4/NONO-RAB11FIP3 axis promotes immune evasion in gastric cancer via facilitating PD-L1 endosome recycling. In Cancer letters, 584, 216618. doi:10.1016/j.canlet.2024.216618. https://pubmed.ncbi.nlm.nih.gov/38211652/
2. Tong, Dandan, Liang, Ya-Nan, Stepanova, A A, Zhang, Fengmin, Vasilyeva, N V. . Increased Eps15 homology domain 1 and RAB11FIP3 expression regulate breast cancer progression via promoting epithelial growth factor receptor recycling. In Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 39, 1010428317691010. doi:10.1177/1010428317691010. https://pubmed.ncbi.nlm.nih.gov/28215104/
3. Liu, Yu, Liang, Yanan, Li, Ming, Tong, Dandan, Jin, Xiaoming. 2018. Eps15 homology domain 1 promotes the evolution of papillary thyroid cancer by regulating endocytotic recycling of epidermal growth factor receptor. In Oncology letters, 16, 4263-4270. doi:10.3892/ol.2018.9200. https://pubmed.ncbi.nlm.nih.gov/30214560/
4. Baker, Brennan H, Freije, Sophie, MacDonald, James W, Sathyanarayana, Sheela, Paquette, Alison G. 2024. Placental transcriptomic signatures of prenatal and preconceptional maternal stress. In Molecular psychiatry, 29, 1179-1191. doi:10.1038/s41380-023-02403-6. https://pubmed.ncbi.nlm.nih.gov/38212375/
5. Collins, Louise L, Simon, Glenn, Matheson, Johanne, Prekeris, Rytis, Gould, Gwyn W. 2012. Rab11-FIP3 is a cell cycle-regulated phosphoprotein. In BMC cell biology, 13, 4. doi:10.1186/1471-2121-13-4. https://pubmed.ncbi.nlm.nih.gov/22401586/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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