C57BL/6JCya-Tmc3em1/Cya
Common Name:
Tmc3-KO
Product ID:
S-KO-18122
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Tmc3-KO
Strain ID
KOCMP-233424-Tmc3-B6J-VB
Gene Name
Product ID
S-KO-18122
Gene Alias
9030203A06
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
7
Phenotype
Document
Application
--
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Tmc3em1/Cya mice (Catalog S-KO-18122) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000039317
NCBI RefSeq
NM_177695
Target Region
Exon 2~3
Size of Effective Region
~5.2 kb
Detailed Document
Overview of Gene Research
Tmc3, a member of the transmembrane channel-like (TMC) gene family, encodes a protein predicted to have 6-10 transmembrane domains and a conserved TMC domain [4]. Tmc3 may function as a mechanosensitive ion channel, as it is the most highly expressed channel in human cardiac fibroblasts among TMC family members [1]. It has also been associated with blood pressure regulation, as single predicted loss-of-function (pLoF) variants in Tmc3 were found to be associated with blood pressure in a study analyzing the UK Biobank whole-exome sequencing dataset [5].
In a study on extraganglionic vagal mechanoreceptors, Tmc3 was identified as a marker of potential gastrointestinal mechanoreceptors among extraganglionic neurons in the mouse vagus nerve [3]. In the context of renal clear cell carcinoma (RCCC), Tmc3 was significantly related to the overall survival of RCCC patients and was positively correlated with the degree of immune infiltration [2].
In conclusion, Tmc3 appears to have diverse functions. It may be involved in mechanosensation in cardiac fibroblasts and the vagus nerve, and it also plays a role in blood pressure regulation and the prognosis and immune infiltration of RCCC. The findings from studies on Tmc3 contribute to our understanding of its functions in normal physiological processes and disease conditions.
References：
1. Mitrokhin, Vadim, Bilichenko, Andrei, Kazanski, Viktor, Kamkin, Andre, Mladenov, Mitko. 2023. Transcriptomic profile of the mechanosensitive ion channelome in human cardiac fibroblasts. In Experimental biology and medicine (Maywood, N.J.), 248, 2341-2350. doi:10.1177/15353702231218488. https://pubmed.ncbi.nlm.nih.gov/38158807/
2. Tang, Wenbin, Shi, Zhiyuan, Zhu, Yasheng, Xu, Weidong, Wang, Junkai. 2023. Comprehensive analysis of the prognosis and immune infiltration of TMC family members in renal clear cell carcinoma. In Scientific reports, 13, 11668. doi:10.1038/s41598-023-38914-z. https://pubmed.ncbi.nlm.nih.gov/37468683/
3. Leon-Mercado, Luis, Tinajero, Arely, Gautron, Laurent. 2023. Evidence of extraganglionic vagal mechanoreceptors in the mouse vagus nerve. In Journal of anatomy, 243, 936-950. doi:10.1111/joa.13925. https://pubmed.ncbi.nlm.nih.gov/37403978/
4. Kurima, Kiyoto, Yang, Yandan, Sorber, Katherine, Griffith, Andrew J. . Characterization of the transmembrane channel-like (TMC) gene family: functional clues from hearing loss and epidermodysplasia verruciformis. In Genomics, 82, 300-8. doi:. https://pubmed.ncbi.nlm.nih.gov/12906855/
5. Lecluze, Estelle, Lettre, Guillaume. 2023. Association Analyses of Predicted Loss-of-Function Variants Prioritized 15 Genes as Blood Pressure Regulators. In The Canadian journal of cardiology, 39, 1888-1897. doi:10.1016/j.cjca.2023.07.011. https://pubmed.ncbi.nlm.nih.gov/37451613/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen