C57BL/6JCya-Nrgnem1/Cya
Common Name
Nrgn-KO
Product ID
S-KO-18131
Backgroud
C57BL/6JCya
Strain ID
KOCMP-64011-Nrgn-B6J-VB
Status
When using this mouse strain in a publication, please cite “Nrgn-KO Mouse (Catalog S-KO-18131) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
The standard delivery applies for a guaranteed minimum of three heterozygous carriers. Breeding services for homozygous carriers and/or specified sex are available.
Basic Information
Strain Name
Nrgn-KO
Strain ID
KOCMP-64011-Nrgn-B6J-VB
Gene Name
Product ID
S-KO-18131
Gene Alias
NG, RC3, Pss1, NG/RC3, 0710001B06Rik
Background
C57BL/6JCya
Gene Full Name
neurogranin
Modification
Conventional knockout
NCBI ID
Phenotype
Chromosome
Chr 9 (Mouse)
Application
--
Datasheet
Strain Description
Ensembl Transcript ID
ENSMUST00000065668
NCBI Transcript ID
NM_022029
Target Region
Exon 2~3
Size of Effective Region
~1.2 kb
Overview of Gene Research
Nrgn, also known as neurogranin, is a small brain protein expressed in various telencephalic areas. It plays an essential role in synaptic plasticity by regulating the availability of calmodulin (CaM) [4].
In glioma, NRGN has been identified as a tumor suppressor. LINC00641 can positively regulate NRGN by absorbing miR-4262, and overexpression of NRGN prevents cell proliferation and enhances apoptosis [1].
In mild traumatic brain injury patients, serum NRGN levels were significantly higher in those with structural lesions compared to those without, suggesting its potential as a diagnostic biomarker [2].
Also, in schizophrenia, a single-nucleotide polymorphism (rs12807809) in the NRGN gene was associated with abnormal Papez circuit function, specifically in the functional connectivity between the hippocampus and certain brain regions [3].
In addition, NRGN polymorphisms are associated with schizophrenia, major depressive disorder, and bipolar disorder in the Han Chinese population [5].
In conclusion, Nrgn is crucial for synaptic plasticity. Its role in various diseases such as glioma, mild traumatic brain injury, and mental disorders has been revealed through different research models. These findings contribute to understanding the pathogenesis of these diseases and may provide new targets for diagnosis and treatment.
References：
1. Yang, Jinghui, Yu, Duo, Liu, Xueshibojie, Changyong, E, Yu, Shan. 2020. LINC00641/miR-4262/NRGN axis confines cell proliferation in glioma. In Cancer biology & therapy, 21, 758-766. doi:10.1080/15384047.2020.1776581. https://pubmed.ncbi.nlm.nih.gov/32543324/
2. Çevik, Serdar, Özgenç, Mustafa Murat, Güneyk, Ahmet, Hanımoğlu, Hakan, Kaynar, Mehmet Yaşar. 2019. NRGN, S100B and GFAP levels are significantly increased in patients with structural lesions resulting from mild traumatic brain injuries. In Clinical neurology and neurosurgery, 183, 105380. doi:10.1016/j.clineuro.2019.105380. https://pubmed.ncbi.nlm.nih.gov/31234132/
3. Zhang, Yifan, Gong, Xiaohong, Yin, Zhiyang, Wang, Fei, Tang, Yanqing. 2019. Association between NRGN gene polymorphism and resting-state hippocampal functional connectivity in schizophrenia. In BMC psychiatry, 19, 108. doi:10.1186/s12888-019-2088-5. https://pubmed.ncbi.nlm.nih.gov/30953482/
4. Rueda-García, Valentina, Rondón-Barragán, Iang Schroniltgen. 2023. Molecular Characterization of Neurogranin (NRGN) Gene from Red‑Bellied Pacu (Piaractus brachypomus). In Molecular neurobiology, 61, 2620-2630. doi:10.1007/s12035-023-03700-5. https://pubmed.ncbi.nlm.nih.gov/37922064/
5. Wen, Zujia, Chen, Jianhua, Khan, Raja Amjad Waheed, Li, Wenjin, Shi, Yongyong. 2016. Polymorphisms in NRGN are associated with schizophrenia, major depressive disorder and bipolar disorder in the Han Chinese population. In Journal of affective disorders, 194, 180-7. doi:10.1016/j.jad.2016.01.034. https://pubmed.ncbi.nlm.nih.gov/26828755/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
Contact Us
Connect with our experts for your custom animal model needs. Please fill out the form below to start a conversation or request a quote.
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.
