C57BL/6JCya-Nrgnem1/Cya
Common Name
Nrgn-KO
Product ID
S-KO-18131
Backgroud
C57BL/6JCya
Strain ID
KOCMP-64011-Nrgn-B6J-VB
Status
When using this mouse strain in a publication, please cite “Nrgn-KO Mouse (Catalog S-KO-18131) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
The standard delivery applies for a guaranteed minimum of three heterozygous carriers. Breeding services for homozygous carriers and/or specified sex are available.
Basic Information
Strain Name
Nrgn-KO
Strain ID
KOCMP-64011-Nrgn-B6J-VB
Gene Name
Product ID
S-KO-18131
Gene Alias
NG, RC3, Pss1, NG/RC3, 0710001B06Rik
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 9
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000065668
NCBI RefSeq
NM_022029
Target Region
Exon 2~3
Size of Effective Region
~1.2 kb
Overview of Gene Research
Nrgn, also known as neurogranin, is a small brain protein expressed in various telencephalic areas. It plays an essential role in synaptic plasticity by regulating the availability of calmodulin (CaM) [4].
In glioma, NRGN has been identified as a tumor suppressor. LINC00641 can positively regulate NRGN by absorbing miR-4262, and overexpression of NRGN prevents cell proliferation and enhances apoptosis [1].
In mild traumatic brain injury patients, serum NRGN levels were significantly higher in those with structural lesions compared to those without, suggesting its potential as a diagnostic biomarker [2].
Also, in schizophrenia, a single-nucleotide polymorphism (rs12807809) in the NRGN gene was associated with abnormal Papez circuit function, specifically in the functional connectivity between the hippocampus and certain brain regions [3].
In addition, NRGN polymorphisms are associated with schizophrenia, major depressive disorder, and bipolar disorder in the Han Chinese population [5].
In conclusion, Nrgn is crucial for synaptic plasticity. Its role in various diseases such as glioma, mild traumatic brain injury, and mental disorders has been revealed through different research models. These findings contribute to understanding the pathogenesis of these diseases and may provide new targets for diagnosis and treatment.
References：
1. Yang, Jinghui, Yu, Duo, Liu, Xueshibojie, Changyong, E, Yu, Shan. 2020. LINC00641/miR-4262/NRGN axis confines cell proliferation in glioma. In Cancer biology & therapy, 21, 758-766. doi:10.1080/15384047.2020.1776581. https://pubmed.ncbi.nlm.nih.gov/32543324/
2. Çevik, Serdar, Özgenç, Mustafa Murat, Güneyk, Ahmet, Hanımoğlu, Hakan, Kaynar, Mehmet Yaşar. 2019. NRGN, S100B and GFAP levels are significantly increased in patients with structural lesions resulting from mild traumatic brain injuries. In Clinical neurology and neurosurgery, 183, 105380. doi:10.1016/j.clineuro.2019.105380. https://pubmed.ncbi.nlm.nih.gov/31234132/
3. Zhang, Yifan, Gong, Xiaohong, Yin, Zhiyang, Wang, Fei, Tang, Yanqing. 2019. Association between NRGN gene polymorphism and resting-state hippocampal functional connectivity in schizophrenia. In BMC psychiatry, 19, 108. doi:10.1186/s12888-019-2088-5. https://pubmed.ncbi.nlm.nih.gov/30953482/
4. Rueda-García, Valentina, Rondón-Barragán, Iang Schroniltgen. 2023. Molecular Characterization of Neurogranin (NRGN) Gene from Red‑Bellied Pacu (Piaractus brachypomus). In Molecular neurobiology, 61, 2620-2630. doi:10.1007/s12035-023-03700-5. https://pubmed.ncbi.nlm.nih.gov/37922064/
5. Wen, Zujia, Chen, Jianhua, Khan, Raja Amjad Waheed, Li, Wenjin, Shi, Yongyong. 2016. Polymorphisms in NRGN are associated with schizophrenia, major depressive disorder and bipolar disorder in the Han Chinese population. In Journal of affective disorders, 194, 180-7. doi:10.1016/j.jad.2016.01.034. https://pubmed.ncbi.nlm.nih.gov/26828755/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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