C57BL/6JCya-Cfap20dcem1/Cya
Common Name:
Cfap20dc-KO
Product ID:
S-KO-18154
Background:
C57BL/6JCya
Product Type
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Genotype
Sex
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Basic Information
Strain Name
Cfap20dc-KO
Strain ID
KOCMP-74430-Cfap20dc-B6J-VB
Gene Name
Product ID
S-KO-18154
Gene Alias
4930452B06Rik; 4933406L09Rik
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
14
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Cfap20dcem1/Cya mice (Catalog S-KO-18154) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000102996
NCBI RefSeq
NM_028934
Target Region
Exon 5~7
Size of Effective Region
~41.9 kb
Detailed Document
Overview of Gene Research
Cfap20dc has an associated long non-coding RNA, CFAP20DC-AS1. While the direct function of Cfap20dc itself is not detailed in the provided abstract, the lncRNA CFAP20DC-AS1 is part of a regulatory axis related to breast cancer cell apoptosis. This implies that Cfap20dc may be involved in pathways related to breast cancer cell growth and apoptosis regulation [1].
In the study, ginsenoside Rh2 was found to down-regulate CFAP20DC-AS1. MiR-3614-3p, which potentially binds CFAP20DC-AS1, was up-regulated by Rh2. Deregulation of CFAP20DC-AS1 using siRNA attenuated the expression of miR-3614-3p and vice versa. The target genes of miR-3614-3p, BBX and TNFAIP3, were down-regulated by Rh2 and miR-3614-3p but up-regulated by CFAP20DC-AS1. The Rh2/CFAP20DC-AS1/miR-3614-3p/target gene axis contributes to the antiproliferation activity of Rh2 in breast cancer cells [1].
In conclusion, although the direct function of Cfap20dc is not clear, its associated lncRNA CFAP20DC-AS1 is involved in a regulatory axis that contributes to the antiproliferation activity of ginsenoside Rh2 in breast cancer cells. This indicates a potential role of Cfap20dc in breast cancer-related biological processes, and further in-vivo studies like gene knockout or conditional knockout models could potentially reveal more about its exact function in this context [1].
References：
1. Park, Jae Eun, Ji, Hwee Won, Kim, Hyeon Woo, Jung, Sanghyun, Kim, Sun Jung. 2022. Ginsenoside Rh2 Regulates the CFAP20DC-AS1/MicroRNA-3614-3p/BBX and TNFAIP3 Axis to Induce Apoptosis in Breast Cancer Cells. In The American journal of Chinese medicine, 50, 1703-1717. doi:10.1142/S0192415X22500720. https://pubmed.ncbi.nlm.nih.gov/35787669/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen