C57BL/6JCya-Atp5mc1em1/Cya
Common Name:
Atp5mc1-KO
Product ID:
S-KO-18159
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Atp5mc1-KO
Strain ID
KOCMP-11951-Atp5mc1-B6J-VA
Gene Name
Product ID
S-KO-18159
Gene Alias
Atp5g1
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
11
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Atp5mc1em1/Cya mice (Catalog S-KO-18159) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000090541
NCBI RefSeq
NM_007506
Target Region
Exon 3~5
Size of Effective Region
~5.2 kb
Detailed Document
Overview of Gene Research
Atp5mc1, also known as ATP5G1, is one of the three proteins that comprise subunit c of the F0 complex of the mitochondrial ATP synthase. It is involved in the oxidative phosphorylation pathway, which is crucial for ATP synthesis in mitochondria, and thus plays a significant role in cellular energy metabolism [2].
In various studies, Atp5mc1 has been associated with different disease conditions. In sepsis, its gene expression level showed a negative correlation with the risk of sepsis, suggesting its potential role in the pathogenesis of this condition [1]. In schizophrenia patients, significantly decreased Atp5mc1 mRNA expression levels were observed in plasma and peripheral blood mononuclear cells, indicating its possible involvement in the disease mechanism [3]. In striped hamsters parasitized by fleas, down-regulation of Atp5mc1 was noted, highlighting the importance of mitochondrial function in oxidative stress during host-ectoparasite interactions [4]. In young sheep fed nutrient-deficient diets, Atp5mc1 was downregulated in the hypothalamus, which might be related to the regulation of voluntary feed intake [5]. In radioresistant triple-negative breast cancer cells, co-treatment with melatonin and ortho-topolin riboside decreased Atp5mc1 expression, inhibiting mitochondrial respiration and cell proliferation [6]. In GFM1 knockout cells, upregulation of Atp5mc1 was seen as a compensatory mechanism in response to impaired mitochondrial function [7].
In conclusion, Atp5mc1 is essential for mitochondrial ATP synthesis and cellular energy metabolism. Its abnormal expression is associated with multiple disease states such as sepsis, schizophrenia, host-ectoparasite interactions, feed intake regulation, breast cancer, and mitochondrial function impairment. Research on Atp5mc1 helps to better understand the underlying mechanisms of these diseases and may provide potential therapeutic targets.
References:
1. Sun, Jiaojiao, Wu, Yaxian, Burgess, Smith, Weng, Yuan, Wang, Zhiqiang. 2025. Mitochondrial-related genome-wide Mendelian randomization identifies putatively causal genes in the pathogenesis of sepsis. In Surgery, 181, 109150. doi:10.1016/j.surg.2025.109150. https://pubmed.ncbi.nlm.nih.gov/39933430/
2. Miller, Taylor E, Henkels, Karen M, Huddleston, Mary, Sasaki, Atsuo T, Cho, Kwang-Jin. 2019. Depletion of phosphatidylinositol 4-phosphate at the Golgi translocates K-Ras to mitochondria. In Journal of cell science, 132, . doi:10.1242/jcs.231886. https://pubmed.ncbi.nlm.nih.gov/31331963/
3. Saleh, Amany A, Elhelbawy, Nesreen G, Azmy, Rania M, Donia, Sally S, Abd El Gayed, Eman M. 2022. Evaluation of mRNA expression level of the ATP synthase membrane subunit c locus 1 (ATP5G1) gene in patients with schizophrenia. In Biochemistry and biophysics reports, 30, 101234. doi:10.1016/j.bbrep.2022.101234. https://pubmed.ncbi.nlm.nih.gov/35243015/
4. Lun, Xinchang, Wang, Yiguan, Zhao, Ning, Liang, Ying, Lu, Liang. 2024. Metabolism and immune responses of striped hamsters to ectoparasite challenges: insights from transcriptomic analysis. In Frontiers in immunology, 15, 1516382. doi:10.3389/fimmu.2024.1516382. https://pubmed.ncbi.nlm.nih.gov/39723213/
5. Innes, D J, Hudson, N J, Anderson, S T, Poppi, D P, Quigley, S P. 2023. Differential voluntary feed intake and whole transcriptome profiling in the hypothalamus of young sheep offered CP and phosphorus-deficient diets. In Animal : an international journal of animal bioscience, 17, 100973. doi:10.1016/j.animal.2023.100973. https://pubmed.ncbi.nlm.nih.gov/37738703/
6. Noh, Soon-Wook, Kim, Dae Kyeong, Nam, Seung Min, Cho, Somi Kim, Choi, Hyung-Kyoon. 2024. Co-treatment with melatonin and ortho-topolin riboside exhibits anti-proliferation activity in radioresistant MDA-MB-231 cells by altering metabolic and transcriptomic profiles. In Biochemical and biophysical research communications, 742, 151132. doi:10.1016/j.bbrc.2024.151132. https://pubmed.ncbi.nlm.nih.gov/39667070/
7. Ahmad, Bashir, Dumbuya, John Sieh, Li, Wen, Chen, Xiuling, Lu, Jun. 2025. Evaluation of GFM1 mutations pathogenicity through in silico tools, RNA sequencing and mitophagy pahtway in GFM1 knockout cells. In International journal of biological macromolecules, 304, 140970. doi:10.1016/j.ijbiomac.2025.140970. https://pubmed.ncbi.nlm.nih.gov/39952508/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen