C57BL/6JCya-Scaf11em1/Cya
Common Name
Scaf11-KO
Product ID
S-KO-18170
Backgroud
C57BL/6JCya
Strain ID
KOCMP-72193-Scaf11-B6J-VB
Status
When using this mouse strain in a publication, please cite “Scaf11-KO Mouse (Catalog S-KO-18170) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
The standard delivery applies for a guaranteed minimum of three heterozygous carriers. Breeding services for homozygous carriers and/or specified sex are available.
Basic Information
Strain Name
Scaf11-KO
Strain ID
KOCMP-72193-Scaf11-B6J-VB
Gene Name
Product ID
S-KO-18170
Gene Alias
SIP1, CASP11, SRRP129, Sfrs2ip, Srsf2ip, mKIAA3013, 1110061H03Rik, 2610510E10Rik
Background
C57BL/6JCya
Gene Full Name
SR-related CTD-associated factor 11
Modification
Conventional knockout
NCBI ID
Phenotype
Chromosome
Chr 15 (Mouse)
Application
--
Datasheet
Strain Description
Ensembl Transcript ID
ENSMUST00000047835
NCBI Transcript ID
NM_028148
Target Region
Exon 7~9
Size of Effective Region
~2.1 kb
Overview of Gene Research
SCAF11, also known as SR-related CTD associated factor 11, has been implicated in multiple biological functions and pathways. It has been associated with the ubiquitin-mediated proteolysis pathway [3], and may be involved in processes related to inflammation, immune-related signaling pathways such as oxidative phosphorylation, antimicrobial humoral response, and immunoglobulin complex according to functional enrichment analysis [1].
In breast cancer, knocking down SCAF11 inhibits cell viability and colony-formation, and its expression is significantly correlated with diverse tumor-infiltrating lymphocytes and immune checkpoints, suggesting its role in regulating the immune microenvironment [1].
In hepatocellular carcinoma, suppression of SCAF11 expression inhibits the proliferation, migration, invasion, and induces apoptosis of liver cancer cell lines, indicating that SCAF11 promotes the progression of liver cancer [2].
In conclusion, SCAF11 is involved in multiple biological processes and pathways. Studies using loss-of-function experiments in cancer cell lines have revealed its role in promoting cancer progression in breast and liver cancers, highlighting its potential as a therapeutic target in these disease areas.
References：
1. Chu, Ling, Yi, Qiaoli, Yan, Yuanliang, Liu, Ying, Xu, Zhijie. 2022. A Prognostic Signature Consisting of Pyroptosis-Related Genes and SCAF11 for Predicting Immune Response in Breast Cancer. In Frontiers in medicine, 9, 882763. doi:10.3389/fmed.2022.882763. https://pubmed.ncbi.nlm.nih.gov/35646948/
2. Li, Huihui, Li, Tang, Zhang, Xiaohua. 2022. Identification of a Pyroptosis-Related Prognostic Signature Combined With Experiments in Hepatocellular Carcinoma. In Frontiers in molecular biosciences, 9, 822503. doi:10.3389/fmolb.2022.822503. https://pubmed.ncbi.nlm.nih.gov/35309514/
3. Li, Bohan, Wang, Sha, Duan, Hua, Wang, Yiyi, Guo, Zhengchen. 2020. Discovery of gene module acting on ubiquitin-mediated proteolysis pathway by co-expression network analysis for endometriosis. In Reproductive biomedicine online, 42, 429-441. doi:10.1016/j.rbmo.2020.10.005. https://pubmed.ncbi.nlm.nih.gov/33189575/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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