C57BL/6JCya-Mapk7em1/Cya
Common Name:
Mapk7-KO
Product ID:
S-KO-18172
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Mapk7-KO
Strain ID
KOCMP-23939-Mapk7-B6J-VA
Gene Name
Product ID
S-KO-18172
Gene Alias
BMK-1; BMK1; ERK-5; ERK5; Erk5-T; PRKM7; b2b2346Clo
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
11
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Mapk7em1/Cya mice (Catalog S-KO-18172) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000079080
NCBI RefSeq
NM_011841
Target Region
Exon 4~5
Size of Effective Region
~1.8 kb
Detailed Document
Overview of Gene Research
Mapk7, also known as Mitogen-activated protein kinase 7, is a member of the MAPK family. It plays crucial roles in controlling cell differentiation, proliferation, and survival, and is involved in multiple signaling pathways such as MEF2C/PTEN/AKT, Lrp6/β -catenin, and is related to the function of macrophages like MAPK7/AhR/STAT3 signaling [1,2,3]. Genetic models, especially knockout (KO) mouse models, are valuable for studying its functions.
In a Col2a1 -cre;Mapk7f/f transgenic (a type of conditional knockout, CKO) mouse model, deletion of Mapk7 in cartilage led to kyphosis and osteopenia. Mechanistically, it decreased MEF2C expression, activated PTEN, and opposed PI3K/AKT signaling in vertebral growth plate chondrocytes, impairing chondrocyte hypertrophy and vertebral ossification [1]. In Prx1 -Cre;Mapk7flox/flox mice (another CKO model), depletion of Mapk7 in mesenchymal stem cells (MSCs) caused severe low bone mass and fat accumulation in the bone marrow, as Mapk7 promoted osteogenic differentiation and inhibited adipogenic differentiation of MSCs by activating the Wnt/β -catenin signaling [3].
In conclusion, Mapk7 is essential for normal bone development, especially in vertebral and limb bone development, and in regulating the balance between osteogenic and adipogenic differentiation of MSCs. The KO/CKO mouse models have significantly contributed to understanding the role of Mapk7 in spinal deformities and bone-related diseases, providing a basis for potential therapeutic strategies [1,3].
References：
1. Wu, Chengzhi, Liu, Hengyu, Zhong, Dongmei, Xu, Caixia, Su, Peiqiang. 2023. Mapk7 deletion in chondrocytes causes vertebral defects by reducing MEF2C/PTEN/AKT signaling. In Genes & diseases, 11, 964-977. doi:10.1016/j.gendis.2023.02.012. https://pubmed.ncbi.nlm.nih.gov/37692479/
2. Zhang, Qi, Liu, Ming, Zhang, Jing, Song, Fuyong, Zhou, Jun. 2024. Macrophage MAPK7/AhR/STAT3 Signaling Mediates Mitochondrial ROS Burst and Enterohepatic Inflammatory Responses Induced by Deoxynivalenol Relevant to Low-Dose Exposure in Children. In Environmental science & technology, 58, 18589-18602. doi:10.1021/acs.est.4c05875. https://pubmed.ncbi.nlm.nih.gov/39376183/
3. Li, Chuan, Long, Jiahui, Chen, Shuqing, Zhiheng, Liao, Xu, Caixia. 2025. Mapk7 enhances osteogenesis and suppresses adipogenesis by activating Lrp6/β-catenin signaling axis in mesenchymal stem cells. In Communications biology, 8, 310. doi:10.1038/s42003-025-07765-x. https://pubmed.ncbi.nlm.nih.gov/40000807/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen