C57BL/6JCya-Lrrc37aem1/Cya
Common Name:
Lrrc37a-KO
Product ID:
S-KO-18188
Background:
C57BL/6JCya
Product Type
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Genotype
Sex
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Basic Information
Strain Name
Lrrc37a-KO
Strain ID
KOCMP-237954-Lrrc37a-B6J-VA
Gene Name
Product ID
S-KO-18188
Gene Alias
Gm251
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
11
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Lrrc37aem1/Cya mice (Catalog S-KO-18188) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000153273
NCBI RefSeq
XM_011249376
Target Region
Exon 1
Size of Effective Region
~6.7 kb
Detailed Document
Overview of Gene Research
Lrrc37a is a gene located within the 17q21.31 locus. It is a membrane-associated protein that has been implicated in multiple biological functions. In terms of associated pathways, it may be involved in cellular migration, chemotaxis, and astroglial inflammation [2]. It also seems to play a role in the context of neurodegenerative diseases, making it of significant biological importance. Genetic models such as gene knockout (KO) or conditional knockout (CKO) mouse models could potentially be valuable for further studying its functions.
In post-traumatic stress disorder (PTSD) and major depressive disorder (MDD), Lrrc37a was among the genes identified through single-nucleus RNA-seq analysis of the dorsolateral prefrontal cortex. In MDD samples, it was one of the differentially expressed genes, while in PTSD, genes from the 17q21.31 locus including Lrrc37a2 were identified, highlighting cell-type-specific mechanisms of brain stress response [1]. In Parkinson's disease (PD), the 17q21.31 locus is genetically associated with the disease. Protective sub-haplotypes were associated with increased Lrrc37a/2 copy number and expression in human brain tissue. Lrrc37a/2 was found to interact directly with soluble α-synuclein and co-localize with Lewy bodies in PD brain tissue, indicating its contribution to the association between the 17q21.31 locus and PD [2]. In progressive supranuclear palsy (PSP), γ duplication within the 17q21.31 region up-regulates the expression of Lrrc37a/Lrrc37a2 in neuronal cells, and the copy number of γ is associated with the risk of PSP [3].
In conclusion, Lrrc37a is a gene with functions related to cellular processes like migration and inflammation, and is associated with neurodegenerative diseases such as PD and PSP, as well as mental disorders like PTSD and MDD. Studies on Lrrc37a using KO or CKO mouse models could potentially further clarify its role in these disease conditions, providing insights into the underlying biological mechanisms and potentially leading to new therapeutic strategies [1,2,3].
References：
1. Chatzinakos, Chris, Pernia, Cameron D, Morrison, Filomene G, Ressler, Kerry J, Daskalakis, Nikolaos P. 2023. Single-Nucleus Transcriptome Profiling of Dorsolateral Prefrontal Cortex: Mechanistic Roles for Neuronal Gene Expression, Including the 17q21.31 Locus, in PTSD Stress Response. In The American journal of psychiatry, 180, 739-754. doi:10.1176/appi.ajp.20220478. https://pubmed.ncbi.nlm.nih.gov/37491937/
2. Bowles, Kathryn R, Pugh, Derian A, Liu, Yiyuan, Crary, John F, Goate, A M. 2022. 17q21.31 sub-haplotypes underlying H1-associated risk for Parkinson's disease are associated with LRRC37A/2 expression in astrocytes. In Molecular neurodegeneration, 17, 48. doi:10.1186/s13024-022-00551-x. https://pubmed.ncbi.nlm.nih.gov/35841044/
3. Wang, Hui, Chang, Timothy S, Dombroski, Beth A, Schellenberg, Gerard D, Lee, Wan-Ping. 2025. Copy Number Variation and Haplotype Analysis of 17q21.31 Reveals Increased Risk Associated with Progressive Supranuclear Palsy and Gene Expression Changes in Neuronal Cells. In Movement disorders : official journal of the Movement Disorder Society, , . doi:10.1002/mds.30150. https://pubmed.ncbi.nlm.nih.gov/40055946/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen