C57BL/6JCya-Wdr88em1/Cya
Common Name:
Wdr88-KO
Product ID:
S-KO-18215
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Wdr88-KO
Strain ID
KOCMP-384605-Wdr88-B6J-VA
Gene Name
Product ID
S-KO-18215
Gene Alias
Gm1429; Pqwd
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
7
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Wdr88em1/Cya mice (Catalog S-KO-18215) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000238407
NCBI RefSeq
NM_001370886
Target Region
Exon 2~7
Size of Effective Region
~15.6 kb
Detailed Document
Overview of Gene Research
Wdr88, or WD repeat-containing protein 88, is a gene with an initially unknown function. Its role in biological processes is being explored, and genetic models are valuable for understanding its function more precisely.
In a transcriptome-wide analysis (TWAS) for infectious diseases, a significant association was found between Wdr88 and candidiasis (p = 1.95×10⁻⁶), suggesting its involvement in the genetic susceptibility to this infectious disease [1]. Additionally, in an analysis of exome array data for schizophrenia, gene-wise equivalent of genome-wide significant (GWS) support was identified for Wdr88 (P = 6.5×10⁻⁷), indicating that rare alleles of this gene contribute to the genetic architecture of schizophrenia [2].
In conclusion, Wdr88 appears to be involved in the genetic susceptibility of diseases such as candidiasis and schizophrenia. These findings from different studies using various genetic analysis methods help to understand the role of Wdr88 in disease-related biological processes, providing insights into the genetic mechanisms underlying these diseases.
References：
1. Jiang, Lan, Kerchberger, V Eric, Shaffer, Christian, Stein, C Michael, Feng, QiPing. 2022. Genome-wide association analyses of common infections in a large practice-based biobank. In BMC genomics, 23, 672. doi:10.1186/s12864-022-08888-9. https://pubmed.ncbi.nlm.nih.gov/36167494/
2. Richards, A L, Leonenko, G, Walters, J T, Owen, M J, O'Donovan, M C. 2016. Exome arrays capture polygenic rare variant contributions to schizophrenia. In Human molecular genetics, 25, 1001-7. doi:10.1093/hmg/ddv620. https://pubmed.ncbi.nlm.nih.gov/26740555/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen