C57BL/6JCya-Cckem1/Cya
Common Name:
Cck-KO
Product ID:
S-KO-18236
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
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Basic Information
Strain Name
Cck-KO
Strain ID
KOCMP-12424-Cck-B6J-VB
Gene Name
Product ID
S-KO-18236
Gene Alias
--
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
9
Phenotype
Document
Application
--
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Cckem1/Cya mice (Catalog S-KO-18236) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000216138
NCBI RefSeq
NM_001284508
Target Region
Exon 1~3
Size of Effective Region
~2.9 kb
Detailed Document
Overview of Gene Research
Cck, or cholecystokinin, is a neuropeptide and gut hormone with diverse functions. It modulates digestion, glucose levels, neurotransmitters, and memory. It is involved in pathways related to feeding behavior, central respiratory control, cardiovascular tonus, vigilance states, and nociception. Cck exerts its effects through interaction with two main receptor types, CCK-1R (formerly CCK-A) and CCK-2R (formerly CCK-B), and is of great biological importance in both the central nervous system and the gastrointestinal tract [2,3].
CCK-1R activation in the substantia nigra and striatum elicits dopamine release, and CCK-2R activation in the hippocampus and nigra has neuroprotective effects via AMPK activation, expression of mitochondrial fusion modulators, and autophagy, suggesting potential in treating Alzheimer's and Parkinson's disease [1]. Cck also acts as a peripheral satiety signal, regulating food consumption and affecting gastrointestinal motility, such as inhibiting gastric emptying and colonic transit [2,4,6]. In the context of pain modulation, Cck may act as an endogenous opiate antagonist, with small doses attenuating morphine-induced analgesia [5].
In conclusion, Cck is a multifunctional peptide with key roles in digestion, neural function, and satiety. Its functions in neurodegenerative diseases like Alzheimer's and Parkinson's, as well as in pain modulation and gastrointestinal motility, have been revealed through in-vivo studies. The understanding of Cck from these model-based research efforts provides insights into potential therapeutic strategies for related disease conditions.
References:
1. Reich, Niklas, Hölscher, Christian. 2024. Cholecystokinin (CCK): a neuromodulator with therapeutic potential in Alzheimer's and Parkinson's disease. In Frontiers in neuroendocrinology, 73, 101122. doi:10.1016/j.yfrne.2024.101122. https://pubmed.ncbi.nlm.nih.gov/38346453/
2. Iwanaga, Toshihiko. . Anatomical basis of gastrin- and CCK-secreting cells and their functions. A review. In Biomedical research (Tokyo, Japan), 44, 81-95. doi:10.2220/biomedres.44.81. https://pubmed.ncbi.nlm.nih.gov/37258205/
3. Noble, F, Roques, B P. . CCK-B receptor: chemistry, molecular biology, biochemistry and pharmacology. In Progress in neurobiology, 58, 349-79. doi:. https://pubmed.ncbi.nlm.nih.gov/10368033/
4. Varga, Gábor, Bálint, András, Burghardt, Beáta, D'Amato, Massimo. . Involvement of endogenous CCK and CCK1 receptors in colonic motor function. In British journal of pharmacology, 141, 1275-84. doi:. https://pubmed.ncbi.nlm.nih.gov/15100163/
5. Baber, Nigel Scott, Dourish, Colin Trevor, Hill, David Robert. . The role of CCK caerulein, and CCK antagonists in nociception. In Pain, 39, 307-328. doi:10.1016/0304-3959(89)90045-6. https://pubmed.ncbi.nlm.nih.gov/2694075/
6. Cooper, S J, Dourish, C T. . Multiple cholecystokinin (CCK) receptors and CCK-monoamine interactions are instrumental in the control of feeding. In Physiology & behavior, 48, 849-57. doi:. https://pubmed.ncbi.nlm.nih.gov/1982361/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen