C57BL/6JCya-Pabpc1em1/Cya
Common Name:
Pabpc1-KO
Product ID:
S-KO-18241
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Pabpc1-KO
Strain ID
KOCMP-18458-Pabpc1-B6J-VB
Gene Name
Product ID
S-KO-18241
Gene Alias
PABP; Pabp1; PabpI; Pabpl1; ePAB
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
15
Phenotype
Document
Application
--
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Pabpc1em1/Cya mice (Catalog S-KO-18241) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000001809
NCBI RefSeq
NM_008774
Target Region
Exon 2~3
Size of Effective Region
~1.4 kb
Detailed Document
Overview of Gene Research
Pabpc1, short for poly A-binding protein cytoplasmic 1, is a highly conserved multifunctional RNA-binding protein. It is a central regulator of cytoplasmic mRNA homing, primarily involved in the regulation of mRNA translation and stability, and is implicated in a wide range of physiological and pathological processes by influencing almost every aspect of RNA metabolism [1].
In cancer research, Pabpc1 has been shown to be aberrantly expressed in multiple tumor tissues such as lung, gastric, breast, liver, esophageal, pancreatic, and bladder cancers [1,2,3,5]. For example, in pancreatic ductal adenocarcinoma, USP10 deubiquitinates Pabpc1, which then upregulates CLK2 translation to promote tumor progression [2]. In bladder cancer, the circPTK2/Pabpc1/SETDB1 axis promotes EMT-mediated tumor metastasis and gemcitabine resistance [3]. In esophageal squamous cell carcinoma, Pabpc1 stabilizes IFI27 mRNA, promoting angiogenesis and malignant progression [4]. In pancreatic adenocarcinoma, Pabpc1 promotes cell proliferation and metastasis by regulating COL12A1 expression [5]. However, in gliomas, Pabpc1 was downregulated in tumors with higher malignance, and higher expression was related to better prognosis [7]. Also, Pabpc1 may serve as a biomarker for predicting and diagnosing atherosclerosis and pan-cancer events [6]. In addition, Pabpc1 mediates the degradation of C9orf72-FTLD/ALS GGGGCC repeat RNA, potentially alleviating related diseases [8].
In conclusion, Pabpc1 is crucial for mRNA-related functions. Its abnormal expression and function are closely associated with tumorigenesis and other diseases. The study of Pabpc1 in various disease models, especially in cancer, helps to understand the underlying molecular mechanisms, providing potential directions for diagnosis, treatment, and biomarker discovery.
References:
1. Qi, Ya, Wang, Min, Jiang, Qi. 2022. PABPC1--mRNA stability, protein translation and tumorigenesis. In Frontiers in oncology, 12, 1025291. doi:10.3389/fonc.2022.1025291. https://pubmed.ncbi.nlm.nih.gov/36531055/
2. Li, Tian-Jiao, Jin, Kai-Zhou, Zhou, Hong-Yu, Yu, Xian-Jun, Wu, Wei-Ding. 2023. Deubiquitinating PABPC1 by USP10 upregulates CLK2 translation to promote tumor progression in pancreatic ductal adenocarcinoma. In Cancer letters, 576, 216411. doi:10.1016/j.canlet.2023.216411. https://pubmed.ncbi.nlm.nih.gov/37757903/
3. Meng, Xiangui, Xiao, Wen, Sun, Jiayin, Zhang, Xiaoping, Dong, Wei. 2022. CircPTK2/PABPC1/SETDB1 axis promotes EMT-mediated tumor metastasis and gemcitabine resistance in bladder cancer. In Cancer letters, 554, 216023. doi:10.1016/j.canlet.2022.216023. https://pubmed.ncbi.nlm.nih.gov/36436682/
4. Zhang, Ying, Chen, Chuangzhen, Liu, Zhaoyong, Hu, Wang, Lin, Zhixiong. 2022. PABPC1-induced stabilization of IFI27 mRNA promotes angiogenesis and malignant progression in esophageal squamous cell carcinoma through exosomal miRNA-21-5p. In Journal of experimental & clinical cancer research : CR, 41, 111. doi:10.1186/s13046-022-02339-9. https://pubmed.ncbi.nlm.nih.gov/35346324/
5. Yao, Weijie, Yao, Yanrong, He, Wen, Wang, Genwang, Wang, Zuozheng. . PABPC1 promotes cell proliferation and metastasis in pancreatic adenocarcinoma by regulating COL12A1 expression. In Immunity, inflammation and disease, 11, e919. doi:10.1002/iid3.919. https://pubmed.ncbi.nlm.nih.gov/37506150/
6. Lin, Miao, Hu, Liubing, Shen, Si, Wang, Hao, Xu, Anding. 2024. Atherosclerosis-related biomarker PABPC1 predicts pan-cancer events. In Stroke and vascular neurology, 9, 108-125. doi:10.1136/svn-2022-002246. https://pubmed.ncbi.nlm.nih.gov/37311641/
7. Wang, Qiangwei, Wang, Zhiliang, Bao, Zhaoshi, Wang, Zheng, Jiang, Tao. 2019. PABPC1 relevant bioinformatic profiling and prognostic value in gliomas. In Future oncology (London, England), 16, 4279-4288. doi:10.2217/fon-2019-0268. https://pubmed.ncbi.nlm.nih.gov/31797689/
8. Uozumi, Ryota, Mori, Kohji, Gotoh, Shiho, Akamine, Shoshin, Ikeda, Manabu. 2024. PABPC1 mediates degradation of C9orf72-FTLD/ALS GGGGCC repeat RNA. In iScience, 27, 109303. doi:10.1016/j.isci.2024.109303. https://pubmed.ncbi.nlm.nih.gov/38444607/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen