C57BL/6JCya-Bollem1/Cya
Common Name:
Boll-KO
Product ID:
S-KO-18245
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Boll-KO
Strain ID
KOCMP-75388-Boll-B6J-VA
Gene Name
Product ID
S-KO-18245
Gene Alias
4930554P13Rik; 4930597B14Rik
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
1
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Bollem1/Cya mice (Catalog S-KO-18245) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000087585
NCBI RefSeq
NM_029267
Target Region
Exon 4~6
Size of Effective Region
~9.4 kb
Detailed Document
Overview of Gene Research
BOLL, also known as boule, has been associated with several biological processes and disease conditions. In genetic studies, its loci have shown significance in certain pathways. For instance, in relation to intracranial aneurysm (IA), genome-wide association studies have reported an association between BOLL and endothelin receptor type A (EDNRA) loci. Pair-wise interaction analyses in a Korean adult cohort indicated that rather than a single-SNP effect of BOLL or EDNRA on IA development, they showed a synergistic effect on IA formation via multifactorial pair-wise interactions [1].
In gastric cancer research, BOLL has been identified as a critical RNA-binding protein (RBP). A prognostic risk model, established by screening differentially expressed RBP genes from the TCGA database, led to the discovery that BOLL is associated with mitochondrial function. Gene Set Enrichment analysis (GSEA) supported this finding. In vitro and in vivo experiments demonstrated that circ_0088300 upregulates the expression level of BOLL, and this upregulation promotes gastric cancer growth and metastasis by promoting mitochondrial metabolic reprogramming [2].
In conclusion, BOLL plays important roles in both intracranial aneurysm formation through its interaction with EDNRA and in gastric cancer growth and metastasis by regulating mitochondrial metabolic reprogramming. These findings from functional studies provide insights into the biological functions of BOLL and its implications in disease-related processes, which could potentially contribute to the development of new strategies for disease treatment and prevention.
References:
1. Hong, Eun Pyo, Youn, Dong Hyuk, Kim, Bong Jun, Park, Jeong Jin, Jeon, Jin Pyeong. 2022. Novel Genome-Wide Interactions Mediated via BOLL and EDNRA Polymorphisms in Intracranial Aneurysm. In Journal of Korean Neurosurgical Society, 66, 409-417. doi:10.3340/jkns.2022.0026. https://pubmed.ncbi.nlm.nih.gov/36274247/
2. Chu, Songtao, Fei, Bingyuan, Yu, Miao. 2023. Molecular Mechanism of Circ_0088300-BOLL Interaction Regulating Mitochondrial Metabolic Reprogramming and Involved in Gastric Cancer Growth and Metastasis. In Journal of proteome research, 22, 3793-3810. doi:10.1021/acs.jproteome.3c00476. https://pubmed.ncbi.nlm.nih.gov/37953520/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen