C57BL/6JCya-Sorl1em1/Cya
Common Name
Sorl1-KO
Product ID
S-KO-18252
Backgroud
C57BL/6JCya
Strain ID
KOCMP-20660-Sorl1-B6J-VB
When using this mouse strain in a publication, please cite “Sorl1-KO Mouse (Catalog S-KO-18252) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Sorl1-KO
Strain ID
KOCMP-20660-Sorl1-B6J-VB
Gene Name
Product ID
S-KO-18252
Gene Alias
2900010L19Rik, LR11, SorLA, gp250, mSorLA
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 9
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000060989
NCBI RefSeq
NM_011436
Target Region
Exon 5
Size of Effective Region
~0.1 kb
Overview of Gene Research
SORL1, also known as LR11, is a type I transmembrane protein belonging to both the low-density lipoprotein receptor (LDLR) family and the vacuolar protein sorting 10 (VPS10) domain receptor family. It is genetically implicated in Alzheimer's disease (AD) and is a key regulator in the trafficking and processing of amyloid precursor protein (APP), contributing to endosomal degradation and recycling pathways in neurons [1,3].
Loss of SORL1 in mouse models leads to deficits in learning and memory, down-regulation of brain-derived neurotrophic factor in the hippocampus and cortex, and amyloid β-protein deposits in the brain [4]. In human induced pluripotent stem cell-derived neurons, SORL1 depletion impairs endosomal trafficking of proteins like APP, GLUA1, and TRKB, affecting endosomal recycling and neuronal activity [1]. SORL1-null induced pluripotent stem cells differentiated into different cell types show that SORL1 loss leads to neuron-specific reduction in apolipoprotein E (APOE) and clusterin (CLU) [2].
In conclusion, SORL1 plays a crucial role in endosomal trafficking and recycling in neurons, with its deficiency being closely associated with Alzheimer's disease-related phenotypes. Studies using knockout models have significantly enhanced our understanding of SORL1's functions in the context of AD, highlighting its potential as a therapeutic target for this neurodegenerative disease.
References：
1. Mishra, Swati, Knupp, Allison, Szabo, Marcell P, Andersen, Olav M, Young, Jessica E. 2022. The Alzheimer's gene SORL1 is a regulator of endosomal traffic and recycling in human neurons. In Cellular and molecular life sciences : CMLS, 79, 162. doi:10.1007/s00018-022-04182-9. https://pubmed.ncbi.nlm.nih.gov/35226190/
2. Lee, Hyo, Aylward, Aimee J, Pearse, Richard V, Young, Jessica E, Young-Pearse, Tracy L. 2023. Cell-type-specific regulation of APOE and CLU levels in human neurons by the Alzheimer's disease risk gene SORL1. In Cell reports, 42, 112994. doi:10.1016/j.celrep.2023.112994. https://pubmed.ncbi.nlm.nih.gov/37611586/
3. Yin, Rui-Hua, Yu, Jin-Tai, Tan, Lan. 2014. The Role of SORL1 in Alzheimer's Disease. In Molecular neurobiology, 51, 909-18. doi:10.1007/s12035-014-8742-5. https://pubmed.ncbi.nlm.nih.gov/24833601/
4. Zhao, Mingri, Chen, Xun, Liu, Jiangfeng, Liu, Mujun, Hou, Deren. 2023. Sorl1 knockout inhibits expression of brain-derived neurotrophic factor: involvement in the development of late-onset Alzheimer's disease. In Neural regeneration research, 19, 1602-1607. doi:10.4103/1673-5374.387975. https://pubmed.ncbi.nlm.nih.gov/38051905/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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