C57BL/6JCya-Ptger1em1/Cya
Common Name:
Ptger1-KO
Product ID:
S-KO-18272
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Ptger1-KO
Strain ID
KOCMP-19216-Ptger1-B6J-VA
Gene Name
Product ID
S-KO-18272
Gene Alias
EP1; Ptgerep1
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
8
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Ptger1em1/Cya mice (Catalog S-KO-18272) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000019608
NCBI RefSeq
NM_013641
Target Region
Exon 2
Size of Effective Region
~1.6 kb
Detailed Document
Overview of Gene Research
Ptger1, also known as the E-prostanoid 1 receptor, is a G-protein coupled receptor that binds prostaglandin E2 (PGE2). It is involved in multiple signaling pathways, such as the PKC/Nrf2 cascade, and plays significant roles in various biological processes and disease conditions [1].
In diabetic mouse models, PTGER1 deletion attenuated renal injury, including albuminuria, mesangial matrix expansion, and glomerular hypertrophy. EP1 antagonism also decreased angiotensin II-mediated superoxide generation in cultured podocytes, suggesting that PTGER1 activation contributes to diabetic nephropathy progression in podocytes, proximal tubule, and the vasculature [2]. In cardiomyocytes, genetic depletion of EP1 in mice worsened doxorubicin-induced cardiac injury, while EP1 activation protected cardiomyocytes from doxorubicin-induced ferroptosis by promoting Nrf2-driven anti-oxidative gene expression [1].
In conclusion, Ptger1 is crucial in processes like cardiac protection against ferroptosis and renal response in diabetes. Gene knockout mouse models have revealed its role in these disease areas, highlighting its potential as a therapeutic target for conditions such as diabetic nephropathy and doxorubicin-induced cardiomyopathy.
References:
1. Wang, Bei, Jin, Yuxuan, Liu, Jiao, Zuo, Shengkai, Yu, Ying. 2023. EP1 activation inhibits doxorubicin-cardiomyocyte ferroptosis via Nrf2. In Redox biology, 65, 102825. doi:10.1016/j.redox.2023.102825. https://pubmed.ncbi.nlm.nih.gov/37531930/
2. Thibodeau, Jean-François, Nasrallah, Rania, Carter, Anthony, Hébert, Richard L, Kennedy, Christopher R J. 2013. PTGER1 deletion attenuates renal injury in diabetic mouse models. In The American journal of pathology, 183, 1789-1802. doi:10.1016/j.ajpath.2013.08.022. https://pubmed.ncbi.nlm.nih.gov/24113456/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen