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C57BL/6JCya-Mrto4em1/Cya
Common Name:
Mrto4-KO
Product ID:
S-KO-18292
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Mrto4-KO
Strain ID
KOCMP-69902-Mrto4-B6J-VB
Gene Name
Mrto4
Product ID
S-KO-18292
Gene Alias
2610012O22Rik; Mg684; Mrt4
Background
C57BL/6JCya
NCBI ID
69902
Modification
Conventional knockout
Chromosome
4
Phenotype
MGI:1917152
Document
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Application
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Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Mrto4em1/Cya mice (Catalog S-KO-18292) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000102503
NCBI RefSeq
NM_001290810
Target Region
Exon 3~8
Size of Effective Region
~3.5 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Mrto4, short for MRT4 Homolog, Ribosome Maturation Factor, is involved in ribosome biogenesis [4]. It contains a C-terminal extension similar to ribosomal P proteins and undergoes phosphorylation, with serines in its acidic C-termini phosphorylated by CK2 kinase [4]. This modification impacts its molecular behavior during nucleolar stress, suggesting a role in connecting ribosome biogenesis with cellular metabolism [4].

In cancer research, Mrto4 is often upregulated in various cancer cells. In hepatocellular carcinoma (HCC), it is an independent prognostic risk factor. Mrto4 accelerates glycolysis of HCC cells by inhibiting ALDOB, promoting cell proliferation and invasion while suppressing apoptosis [1]. It also has implications in the tumor microenvironment of HCC, with overexpression associated with poor prognosis, and it is correlated with the stage and grade of HCC patients, as well as drug sensitivity [2]. In colorectal cancer, Mrto4 is highly expressed, potentially influencing its progression [3]. Bioinformatics analysis in colorectal cancer also identified Mrto4 as a hub gene in co-expression modules related to novel lncRNAs, which may be involved in cancer-related cellular pathways [5]. In infiltrative gastric cancer, Mrto4 was among the top 10 up-regulated proteins, and the up-regulated proteins were enriched in processes like DNA replication and ribosome biogenesis [6].

In summary, Mrto4 plays crucial roles in ribosome biogenesis and is significantly involved in the progression of multiple cancers, including HCC, colorectal cancer, and infiltrative gastric cancer. Studies on Mrto4, especially through its role in various disease-related biological processes, provide potential therapeutic targets for these cancers.

References:
1. Zheng, Yongyuan, Huang, Yansong, Li, Weibing, Cheng, Hongqiu. 2024. MRTO4 Enhances Glycolysis to Facilitate HCC Progression by Inhibiting ALDOB. In Medical science monitor : international medical journal of experimental and clinical research, 30, e944685. doi:10.12659/MSM.944685. https://pubmed.ncbi.nlm.nih.gov/38778508/
2. Liang, Baobao, Li, Lan, He, Chenyang, Wang, Meng, Mao, Guochao. 2024. MRTO4 acts as an independent prognostic and immunological biomarker and is correlated with tumor microenvironment in hepatocellular carcinoma. In Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 57, e13780. doi:10.1590/1414-431X2024e13780. https://pubmed.ncbi.nlm.nih.gov/39504066/
3. Luo, Huanping. . Roles of WDR12 and MRTO4 genes in colorectal cancer. In Medicine, 103, e41048. doi:10.1097/MD.0000000000041048. https://pubmed.ncbi.nlm.nih.gov/39969382/
4. Michalec-Wawiorka, Barbara, Wawiorka, Leszek, Derylo, Kamil, Szajwaj, Monika, Tchorzewski, Marek. 2015. Molecular behavior of human Mrt4 protein, MRTO4, in stress conditions is regulated by its C-terminal region. In The international journal of biochemistry & cell biology, 69, 233-40. doi:10.1016/j.biocel.2015.10.018. https://pubmed.ncbi.nlm.nih.gov/26494001/
5. Heidari, Razieh, Assadollahi, Vahideh, Marashi, Seyedeh Negar, Elahian, Fatemeh, Mirzaei, Seyed Abbas. 2025. Identification of Novel lncRNAs Related to Colorectal Cancer Through Bioinformatics Analysis. In BioMed research international, 2025, 5538575. doi:10.1155/bmri/5538575. https://pubmed.ncbi.nlm.nih.gov/39949372/
6. Zhang, Li-Hua, Zhuo, Hui-Qin, Hou, Jing-Jing, Cheng, Jia, Cai, Jian-Chun. . Proteomic signatures of infiltrative gastric cancer by proteomic and bioinformatic analysis. In World journal of gastrointestinal oncology, 14, 2097-2107. doi:10.4251/wjgo.v14.i11.2097. https://pubmed.ncbi.nlm.nih.gov/36438703/
Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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