C57BL/6JCya-Utp14aem1/Cya
Common Name:
Utp14a-KO
Product ID:
S-KO-18297
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Utp14a-KO
Strain ID
KOCMP-72554-Utp14a-B6J-VB
Gene Name
Product ID
S-KO-18297
Gene Alias
2700066J21Rik; JsdX; NY-CO-16; SDCCAG16; mKIAA0266
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
X
Phenotype
Document
Application
--
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Utp14aem1/Cya mice (Catalog S-KO-18297) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000080713
NCBI RefSeq
NM_028276.1
Target Region
Exon 7~11
Size of Effective Region
~3.3 kb
Detailed Document
Overview of Gene Research
Utp14a, also known as U three protein 14a, is an essential component of a large ribonucleoprotein complex. It is involved in ribosome biogenesis, as it activates the RNA helicase DHX37 to facilitate maturation of the small ribosomal subunit [4]. Moreover, it is associated with multiple cellular regulatory pathways and has significant biological importance in processes such as cell proliferation, angiogenesis, and tumorigenesis. Genetic models can be valuable for studying its functions in vivo.
In obesity-induced cardiac injury, Utp14a was identified as a hub gene. Obesity-related pathological changes in the heart, like increased collagen fibers and decreased microvessel proliferation, may be modulated by Utp14a along with other genes, potentially affecting cardiac microcirculatory function [1]. In colorectal cancer, knockdown of hUTP14a (human Utp14a) impairs tube formation and migration of endothelial cells, indicating its role in promoting angiogenesis by upregulating PDGFA expression [2]. In esophageal squamous cell carcinoma, knockdown of Utp14A suppresses cell migration and proliferation, suggesting it promotes tumor proliferation and metastasis via the PERK/eIF2a/GRP78 signalling pathway [3].
In conclusion, Utp14a plays crucial roles in ribosome biogenesis, angiogenesis, and tumor-related processes. Model-based research, especially loss-of-function experiments in relevant disease models such as obesity-induced cardiac injury, colorectal cancer, and esophageal squamous cell carcinoma, has revealed its significance in these biological functions and disease conditions. Understanding Utp14a provides insights into the underlying mechanisms of these diseases, potentially offering new strategies for treatment.
References:
1. Pan, Xiaoyu, Chen, Shuchun, Chen, Xing, Zhen, Ruoxi, Ban, Jiangli. 2022. UTP14A, DKC1, DDX10, PinX1, and ESF1 Modulate Cardiac Angiogenesis Leading to Obesity-Induced Cardiac Injury. In Journal of diabetes research, 2022, 2923291. doi:10.1155/2022/2923291. https://pubmed.ncbi.nlm.nih.gov/35734237/
2. Ren, Pengwei, Sun, Xiaoyan, Zhang, Chunfeng, Xing, Baocai, Du, Xiaojuan. 2019. Human UTP14a promotes angiogenesis through upregulating PDGFA expression in colorectal cancer. In Biochemical and biophysical research communications, 512, 871-876. doi:10.1016/j.bbrc.2019.03.142. https://pubmed.ncbi.nlm.nih.gov/30929921/
3. Li, Kun-Kun, Mao, Cheng-Yi, Ma, Qiang, Guo, Wei, Zhao, Xiao-Long. 2021. U three protein 14a (UTP14A) promotes tumour proliferation and metastasis via the PERK/eIF2a/GRP78 signalling pathway in oesophageal squamous cell carcinoma. In Journal of Cancer, 12, 134-140. doi:10.7150/jca.44649. https://pubmed.ncbi.nlm.nih.gov/33391409/
4. Boneberg, Franziska M, Brandmann, Tobias, Kobel, Lena, Kutay, Ulrike, Jinek, Martin. 2019. Molecular mechanism of the RNA helicase DHX37 and its activation by UTP14A in ribosome biogenesis. In RNA (New York, N.Y.), 25, 685-701. doi:10.1261/rna.069609.118. https://pubmed.ncbi.nlm.nih.gov/30910870/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen