C57BL/6JCya-Lamb1em1/Cya
Common Name:
Lamb1-KO
Product ID:
S-KO-18298
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
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Basic Information
Strain Name
Lamb1-KO
Strain ID
KOCMP-16777-Lamb1-B6J-VB
Gene Name
Product ID
S-KO-18298
Gene Alias
D130003D08Rik; Lamb-1; Lamb1-1
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
12
Phenotype
Document
Application
--
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Lamb1em1/Cya mice (Catalog S-KO-18298) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000002979
NCBI RefSeq
NM_008482
Target Region
Exon 5~6
Size of Effective Region
~0.3 kb
Detailed Document
Overview of Gene Research
LAMB1, encoding laminin subunit beta 1, is a key component of the extracellular matrix (ECM). Laminin, consisting of one α-, one β-, and one γ-chain, is crucial for bridging the internal and external environment of cells and transmitting signals. LAMB1 is involved in attachment, migration, and organization during development, and is associated with pathways like PI3K-Akt, focal adhesion, and ECM-receptor interaction [2,4].
In multiple cancers, LAMB1 shows significance. In hepatocellular carcinoma (HCC), DDX24 binds LAMB1 mRNA and increases its stability, promoting HCC progression, suggesting the RFX8/DDX24/LAMB1 axis as a potential therapeutic target [1]. In gastric cancer, LAMB1 is upregulated, related to T stage and poor prognosis, and may be associated with tumor microenvironmental changes [2]. It also promotes gastric cancer cell growth and motility via the ERK/c-Jun axis [4]. In nasopharyngeal carcinoma, high LAMB1 expression is associated with an immune-suppressive tumor microenvironment and enhanced cell proliferation, migration, and invasion [9]. In addition, in prostate cancer, sEV protein LAMB1 is highly expressed in metastatic patients' plasma, showing promise for diagnosis and risk stratification [5].
In mice, knockdown of LAMB1 in the anterior cingulate cortex exacerbates pain sensitivity and induces anxiety and depression, revealing its role in modulating pain plasticity [3]. In humans, end-truncated LAMB1 is associated with a hippocampal memory defect and a leukoencephalopathy [6,10], and a novel in-frame deletion in LAMB1 is reported in a pediatric patient with brain anomalies and a cerebrovascular event [8]. Also, Lamb1 promotes fracture repair and healing by up-regulating VEGFA expression via the activation of the Wnt signaling pathway to drive endothelial angiogenesis [7].
In conclusion, LAMB1 is essential for various biological processes related to cell-matrix interactions and signal transduction. Its dysregulation is implicated in multiple diseases, especially cancers, pain-related psychiatric disorders, and cerebrovascular and neurodegenerative-like conditions. Studies on LAMB1, including those using genetic models, contribute to understanding disease mechanisms and identifying potential therapeutic targets.
References：
1. Liu, Tianze, Gan, Hairun, He, Simeng, He, Huanhuan, Shan, Hong. . RNA Helicase DDX24 Stabilizes LAMB1 to Promote Hepatocellular Carcinoma Progression. In Cancer research, 82, 3074-3087. doi:10.1158/0008-5472.CAN-21-3748. https://pubmed.ncbi.nlm.nih.gov/35763670/
2. Ran, Tao, Chen, ZhiJi, Zhao, LiWen, Hong, SiYa, Yang, ZhaoXia. . LAMB1 Is Related to the T Stage and Indicates Poor Prognosis in Gastric Cancer. In Technology in cancer research & treatment, 20, 15330338211004944. doi:10.1177/15330338211004944. https://pubmed.ncbi.nlm.nih.gov/33784890/
3. Li, Zhen-Zhen, Han, Wen-Juan, Sun, Zhi-Chuan, Wu, Sheng-Xi, Luo, Ceng. . Extracellular matrix protein laminin β1 regulates pain sensitivity and anxiodepression-like behaviors in mice. In The Journal of clinical investigation, 131, . doi:10.1172/JCI146323. https://pubmed.ncbi.nlm.nih.gov/34156983/
4. Lee, Hana, Kim, Won-Jin, Kang, Hyeon-Gu, Chun, Kyung-Hee, Kim, Seok-Jun. 2021. Upregulation of LAMB1 via ERK/c-Jun Axis Promotes Gastric Cancer Growth and Motility. In International journal of molecular sciences, 22, . doi:10.3390/ijms22020626. https://pubmed.ncbi.nlm.nih.gov/33435161/
5. Pang, Bairen, Wang, Qi, Chen, Haotian, Jiang, Junhui, Li, Yong. 2024. Proteomic Identification of Small Extracellular Vesicle Proteins LAMB1 and Histone H4 for Prostate Cancer Diagnosis and Risk Stratification. In Advanced science (Weinheim, Baden-Wurttemberg, Germany), 11, e2402509. doi:10.1002/advs.202402509. https://pubmed.ncbi.nlm.nih.gov/38590132/
6. Aloui, Chaker, Hervé, Dominique, Marenne, Gaelle, Génin, Emmanuelle, Tournier-Lasserve, Elisabeth. 2021. End-Truncated LAMB1 Causes a Hippocampal Memory Defect and a Leukoencephalopathy. In Annals of neurology, 90, 962-975. doi:10.1002/ana.26242. https://pubmed.ncbi.nlm.nih.gov/34606115/
7. Yang, Yajun, Li, Hangyu, Ma, Zhirong, Li, Zhiran, Gu, Jinxin. 2025. Lamb1-mediated Wnt/β-catenin signaling pathway drives endothelial angiogenesis for fracture healing. In Gene, 959, 149481. doi:10.1016/j.gene.2025.149481. https://pubmed.ncbi.nlm.nih.gov/40221061/
8. Toutouna, Louiza, Beck-Woedl, Stefanie, Feige, Ursula, Bader, Ingrid, Tzschach, Andreas. 2023. Novel homozygous LAMB1 in-frame deletion in a pediatric patient with brain anomalies and cerebrovascular event. In American journal of medical genetics. Part A, 191, 2656-2663. doi:10.1002/ajmg.a.63349. https://pubmed.ncbi.nlm.nih.gov/37466007/
9. Feng, Enzi, Yang, Xinyu, Yang, Jie, Qu, Qianqian, Li, Xiaojiang. 2025. LAMB1 promotes proliferation and metastasis in nasopharyngeal carcinoma and shapes the immune-suppressive tumor microenvironment. In Brazilian journal of otorhinolaryngology, 91, 101551. doi:10.1016/j.bjorl.2024.101551. https://pubmed.ncbi.nlm.nih.gov/39874810/
10. Morel, Hélène, Bailly, Laurent, Urbanczyk, Cédric, Tournier-Lasserve, Elisabeth, Mathey, Guillaume. 2023. Extension of the Clinicoradiologic Spectrum of Newly Described End-Truncating LAMB1 Variations. In Neurology. Genetics, 9, e200069. doi:10.1212/NXG.0000000000200069. https://pubmed.ncbi.nlm.nih.gov/37063705/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen