RFLNA, encoding one of the filamin-binding proteins, plays a crucial role in forming perinuclear actin caps, which are involved in changing nuclear morphology during cell migration and differentiation [1].

A patient with a typical phenotype of spondylocarpotarsal synostosis syndrome was found to have a homozygous frameshift mutation in RFLNA, suggesting that RFLNA is an additional causative gene for this syndrome, and defects in forming actin bundles and perinuclear actin caps may be a critical mechanism for its development [1]. In lung adenocarcinoma, upregulation of RFLNA promotes cell proliferation, migration, invasion, and attenuates apoptosis, indicating its role in promoting cancer development and metastasis [2]. Also, in a pan-cancer analysis, RFLNA was among the genes that significantly interacted with genetic ancestry and exacerbated cancer survival disparities [3].

In summary, RFLNA is important for the formation of perinuclear actin caps. Its mutations or abnormal expression are associated with spondylocarpotarsal synostosis syndrome and lung adenocarcinoma development, as well as cancer survival disparities. Research on RFLNA helps to understand the underlying mechanisms of these diseases and may provide potential therapeutic targets.