C57BL/6JCya-Klhdc9em1/Cya
Common Name:
Klhdc9-KO
Product ID:
S-KO-18381
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Klhdc9-KO
Strain ID
KOCMP-68874-Klhdc9-B6J-VA
Gene Name
Product ID
S-KO-18381
Gene Alias
1190002J23Rik; ESTM31
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
1
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Klhdc9em1/Cya mice (Catalog S-KO-18381) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000061878
NCBI RefSeq
NM_001033039
Target Region
Exon 1~3
Size of Effective Region
~1.7 kb
Detailed Document
Overview of Gene Research
Klhdc9, whose full name is Kelch domain containing 9, likely has functions related to the biological processes it's associated with, though its exact essential function and associated pathways are not clearly detailed from the provided references. However, it may play a role in processes relevant to diseases, suggesting its overall biological importance. Genetic models could potentially be valuable for further study of its functions.
Two studies have identified Klhdc9 as having potential significance in lung adenocarcinoma (LUAD). In one study, it was among five genes used to construct a prognostic risk model for LUAD, and its combined expression levels with certain genes, as well as alone, could be used as independent prognostic markers or drug targets [1]. Another study also found that Klhdc9 might act as an independent biomarker for the prognosis of LUAD through combined DNA methylation and gene expression survival analysis [3]. Additionally, specific isoforms of Klhdc9 were significantly associated with paclitaxel in an in-vitro study, suggesting its potential as an expression-based biomarker for drug response [2].
In conclusion, Klhdc9 appears to have a role in the prognosis of lung adenocarcinoma, potentially serving as a biomarker or drug target. Its specific isoforms may also be relevant in predicting drug response. Research on Klhdc9, potentially through gene knockout or conditional knockout mouse models in the future, could further clarify its functions and contribution to understanding LUAD and other related disease mechanisms.
References:
1. Gao, Chundi, Zhuang, Jing, Li, Huayao, Liu, Lijuan, Sun, Changgang. 2018. Exploration of methylation-driven genes for monitoring and prognosis of patients with lung adenocarcinoma. In Cancer cell international, 18, 194. doi:10.1186/s12935-018-0691-z. https://pubmed.ncbi.nlm.nih.gov/30498398/
2. Safikhani, Zhaleh, Smirnov, Petr, Thu, Kelsie L, Cescon, David, Haibe-Kains, Benjamin. 2017. Gene isoforms as expression-based biomarkers predictive of drug response in vitro. In Nature communications, 8, 1126. doi:10.1038/s41467-017-01153-8. https://pubmed.ncbi.nlm.nih.gov/29066719/
3. Li, Rui, Yang, Yi-E, Yin, Yun-Hong, Li, Hao, Qu, Yi-Qing. 2019. Methylation and transcriptome analysis reveal lung adenocarcinoma-specific diagnostic biomarkers. In Journal of translational medicine, 17, 324. doi:10.1186/s12967-019-2068-z. https://pubmed.ncbi.nlm.nih.gov/31558162/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen