C57BL/6JCya-Igflr1em1/Cya
Common Name
Igflr1-KO
Product ID
S-KO-18394
Backgroud
C57BL/6JCya
Strain ID
KOCMP-101883-Igflr1-B6J-VA
When using this mouse strain in a publication, please cite “Igflr1-KO Mouse (Catalog S-KO-18394) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Igflr1-KO
Strain ID
KOCMP-101883-Igflr1-B6J-VA
Gene Name
Product ID
S-KO-18394
Gene Alias
F630003I17Rik, Tmem149
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 7
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000043850
NCBI RefSeq
NM_145580
Target Region
Exon 2~5
Size of Effective Region
~2.7 kb
Overview of Gene Research
Igflr1, also known as transmembrane protein 149 (TMEM149), is a member of the tumor necrosis factor receptor family [4]. It binds to insulin growth factor-like (IGFL) proteins, such as murine mIGFL and human IGFL1, which are induced in inflammatory skin conditions [4]. The connection between mIGFL and IGFLR1 suggests that it may influence T cell biology within inflammatory skin conditions [4].
In cancer research, IGFLR1 has emerged as a biomarker with potential prognostic and immunomodulatory roles. In colorectal cancer, it is highly expressed in CXCL13 + BHLHE40 + TH1-like cells and CD8 + exhausted T cells, and possesses co-stimulatory functions [1]. In clear cell renal cell cancer (ccRCC), upregulated IGFLR1 is detected compared with para-cancer tissues, significantly affecting the prognosis. It is also positively correlated with the abundance of myeloid derived suppressor cells [2]. In stage II and III colorectal cancer, IGFLR1 is an independent prognostic factor, and its expression is associated with immune cell infiltration [3].
In conclusion, IGFLR1 is involved in immune-related processes, especially in the context of T cell biology in cancer and inflammatory skin conditions. Its role as a prognostic biomarker in multiple cancers, such as ccRCC and colorectal cancer, highlights its potential significance in understanding disease progression and immune-tumor interactions. The study of IGFLR1 in these contexts may provide new insights into cancer prognosis and immunotherapy strategies.
References：
1. Zhang, Lei, Yu, Xin, Zheng, Liangtao, Ouyang, Wenjun, Zhang, Zemin. 2018. Lineage tracking reveals dynamic relationships of T cells in colorectal cancer. In Nature, 564, 268-272. doi:10.1038/s41586-018-0694-x. https://pubmed.ncbi.nlm.nih.gov/30479382/
2. Song, Wenjing, Shao, Youcheng, He, Xin, Wei, Lei, Zhang, Jingwei. 2020. IGFLR1 as a Novel Prognostic Biomarker in Clear Cell Renal Cell Cancer Correlating With Immune Infiltrates. In Frontiers in molecular biosciences, 7, 565173. doi:10.3389/fmolb.2020.565173. https://pubmed.ncbi.nlm.nih.gov/33324675/
3. Jin, Ran, Du, Fenqi, Han, Xinhao, Zhang, Qiuju, Liu, Yanlong. 2024. Prognostic Value of Insulin Growth Factor-Like Receptor 1 (IGFLR1) in Stage II and III Colorectal Cancer and Its Association with Immune Cell Infiltration. In Applied biochemistry and biotechnology, 197, 427-442. doi:10.1007/s12010-024-05006-1. https://pubmed.ncbi.nlm.nih.gov/39141178/
4. Lobito, Adrian A, Ramani, Sree R, Tom, Irene, Ouyang, Wenjun, Gonzalez, Lino C. 2011. Murine insulin growth factor-like (IGFL) and human IGFL1 proteins are induced in inflammatory skin conditions and bind to a novel tumor necrosis factor receptor family member, IGFLR1. In The Journal of biological chemistry, 286, 18969-81. doi:10.1074/jbc.M111.224626. https://pubmed.ncbi.nlm.nih.gov/21454693/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
Contact Us
Connect with our experts for your custom animal model needs. Please fill out the form below to start a conversation or request a quote.
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.