C57BL/6JCya-Igflr1em1/Cya
Common Name:
Igflr1-KO
Product ID:
S-KO-18394
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Igflr1-KO
Strain ID
KOCMP-101883-Igflr1-B6J-VA
Gene Name
Product ID
S-KO-18394
Gene Alias
F630003I17Rik; Tmem149
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
7
Phenotype
Document
Application
--
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Igflr1em1/Cya mice (Catalog S-KO-18394) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000043850
NCBI RefSeq
NM_145580
Target Region
Exon 2~5
Size of Effective Region
~2.7 kb
Detailed Document
Overview of Gene Research
Igflr1, also known as transmembrane protein 149 (TMEM149), is a member of the tumor necrosis factor receptor family [4]. It binds to insulin growth factor-like (IGFL) proteins, such as murine mIGFL and human IGFL1, which are induced in inflammatory skin conditions [4]. The connection between mIGFL and IGFLR1 suggests that it may influence T cell biology within inflammatory skin conditions [4].
In cancer research, IGFLR1 has emerged as a biomarker with potential prognostic and immunomodulatory roles. In colorectal cancer, it is highly expressed in CXCL13 + BHLHE40 + TH1-like cells and CD8 + exhausted T cells, and possesses co-stimulatory functions [1]. In clear cell renal cell cancer (ccRCC), upregulated IGFLR1 is detected compared with para-cancer tissues, significantly affecting the prognosis. It is also positively correlated with the abundance of myeloid derived suppressor cells [2]. In stage II and III colorectal cancer, IGFLR1 is an independent prognostic factor, and its expression is associated with immune cell infiltration [3].
In conclusion, IGFLR1 is involved in immune-related processes, especially in the context of T cell biology in cancer and inflammatory skin conditions. Its role as a prognostic biomarker in multiple cancers, such as ccRCC and colorectal cancer, highlights its potential significance in understanding disease progression and immune-tumor interactions. The study of IGFLR1 in these contexts may provide new insights into cancer prognosis and immunotherapy strategies.
References：
1. Zhang, Lei, Yu, Xin, Zheng, Liangtao, Ouyang, Wenjun, Zhang, Zemin. 2018. Lineage tracking reveals dynamic relationships of T cells in colorectal cancer. In Nature, 564, 268-272. doi:10.1038/s41586-018-0694-x. https://pubmed.ncbi.nlm.nih.gov/30479382/
2. Song, Wenjing, Shao, Youcheng, He, Xin, Wei, Lei, Zhang, Jingwei. 2020. IGFLR1 as a Novel Prognostic Biomarker in Clear Cell Renal Cell Cancer Correlating With Immune Infiltrates. In Frontiers in molecular biosciences, 7, 565173. doi:10.3389/fmolb.2020.565173. https://pubmed.ncbi.nlm.nih.gov/33324675/
3. Jin, Ran, Du, Fenqi, Han, Xinhao, Zhang, Qiuju, Liu, Yanlong. 2024. Prognostic Value of Insulin Growth Factor-Like Receptor 1 (IGFLR1) in Stage II and III Colorectal Cancer and Its Association with Immune Cell Infiltration. In Applied biochemistry and biotechnology, 197, 427-442. doi:10.1007/s12010-024-05006-1. https://pubmed.ncbi.nlm.nih.gov/39141178/
4. Lobito, Adrian A, Ramani, Sree R, Tom, Irene, Ouyang, Wenjun, Gonzalez, Lino C. 2011. Murine insulin growth factor-like (IGFL) and human IGFL1 proteins are induced in inflammatory skin conditions and bind to a novel tumor necrosis factor receptor family member, IGFLR1. In The Journal of biological chemistry, 286, 18969-81. doi:10.1074/jbc.M111.224626. https://pubmed.ncbi.nlm.nih.gov/21454693/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen