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C57BL/6JCya-Vwa5aem1/Cya
Common Name:
Vwa5a-KO
Product ID:
S-KO-18424
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Price:
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Basic Information
Strain Name
Vwa5a-KO
Strain ID
KOCMP-67776-Vwa5a-B6J-VB
Gene Name
Vwa5a
Product ID
S-KO-18424
Gene Alias
5830475I06Rik; BCSC-1; E130119J22; Loh11cr2a
Background
C57BL/6JCya
NCBI ID
67776
Modification
Conventional knockout
Chromosome
9
Phenotype
MGI:1915026
Document
Click here to download >>
Application
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More
Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Vwa5aem1/Cya mice (Catalog S-KO-18424) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000001544
NCBI RefSeq
NM_172767
Target Region
Exon 3~20
Size of Effective Region
~21.0 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Vwa5a, also known as Breast Cancer Suppressor Candidate-1 (BCSC-1), is likely involved in tumor-suppression related functions [3,4,5]. Its potential role in tumor suppression suggests it may be associated with pathways regulating cell growth, proliferation, and metastasis. The gene is of biological importance as its abnormal expression is linked to cancer development. Genetic models could be valuable in further exploring its functions.

In breast cancer, low Vwa5a expression is associated with shorter metastasis-free intervals and poor survival, especially in hormone-receptor-positive breast cancers. In-vitro experiments confirm its tumor-suppressive effect on breast cancer cells in hormone-receptor-positive and triple-negative breast cancer cell lines. Decreasing nuclear expression of Vwa5a is associated with advanced T stage and lymphatic invasion [1].

In colon cancer, Vwa5a is part of an apoptosis-related gene prognostic index (ARGPI). High-risk scores related to the ARGPI, including Vwa5a, are associated with a cell-cycle-pathway enrichment, high TP53 and KRAS mutation rates, and an immunosuppressive state, while low-risk scores are related to drug-metabolism-related pathways and an active immune function [2].

In conclusion, Vwa5a plays a significant role in tumor-suppression, with its abnormal expression linked to poor prognosis in breast and colon cancers. Studies on Vwa5a using various models contribute to understanding cancer-related biological processes, providing potential insights for cancer prognosis and treatment strategies.

References:
1. Koh, Jiwon, Jeong, Dabin, Park, Soo Young, Kim, Sun, Ryu, Han Suk. 2024. Identification of VWA5A as a novel biomarker for inhibiting metastasis in breast cancer by machine-learning based protein prioritization. In Scientific reports, 14, 2459. doi:10.1038/s41598-024-53015-1. https://pubmed.ncbi.nlm.nih.gov/38291227/
2. Tang, Hanmin, Wang, Jing, Luo, Xuehui, Li, Yuesen, Han, Suxia. 2021. An Apoptosis-Related Gene Prognostic Index for Colon Cancer. In Frontiers in cell and developmental biology, 9, 790878. doi:10.3389/fcell.2021.790878. https://pubmed.ncbi.nlm.nih.gov/34957118/
3. Boland, Andrew W, Gas-Pascual, Elisabet, van der Wel, Hanke, Kim, Hyun W, West, Christopher M. 2023. Synergy between a cytoplasmic vWFA/VIT protein and a WD40-repeat F-box protein controls development in Dictyostelium. In Frontiers in cell and developmental biology, 11, 1259844. doi:10.3389/fcell.2023.1259844. https://pubmed.ncbi.nlm.nih.gov/37779900/
4. Anghel, Silvia I, Correa-Rocha, Rafael, Budinska, Eva, Delorenzi, Mauro, Piguet, Vincent. . Breast cancer suppressor candidate-1 (BCSC-1) is a melanoma tumor suppressor that down regulates MITF. In Pigment cell & melanoma research, 25, 482-7. doi:10.1111/j.1755-148X.2012.01018.x. https://pubmed.ncbi.nlm.nih.gov/22594792/
5. Zhou, Y Q, Chen, S L, Ju, J Y, He, Z G, Zhu, L P. 2009. Tumor suppressor function of BCSC-1 in nasopharyngeal carcinoma. In Cancer science, 100, 1817-22. doi:10.1111/j.1349-7006.2009.01261.x. https://pubmed.ncbi.nlm.nih.gov/19656157/
Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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