C57BL/6JCya-Krt79em1/Cya
Common Name
Krt79-KO
Product ID
S-KO-18486
Backgroud
C57BL/6JCya
Strain ID
KOCMP-223917-Krt79-B6J-VA
Status
When using this mouse strain in a publication, please cite “Krt79-KO Mouse (Catalog S-KO-18486) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
The standard delivery applies for a guaranteed minimum of three heterozygous carriers. Breeding services for homozygous carriers and/or specified sex are available.
Basic Information
Strain Name
Krt79-KO
Strain ID
KOCMP-223917-Krt79-B6J-VA
Gene Name
Product ID
S-KO-18486
Gene Alias
--
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 15
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000023799
NCBI RefSeq
NM_146063
Target Region
Exon 3~4
Size of Effective Region
~1.3 kb
Overview of Gene Research
Krt79, a type II cytokeratin, is a key structural protein in epithelial tissues. It has been identified as a regulator of hair canal morphogenesis and regeneration in the skin [1,3]. In the liver, Krt79 is regulated by PPARA, HNF4A, and HER2, and is highly associated with liver damage, suggesting its potential as a diagnostic marker for human liver diseases [1].
In mice, Krt79 is undetectable in normal conditions, but its expression is significantly increased by the PPARA agonist WY-14643 and fenofibrate, and completely abolished in Ppara-null mice [1]. In the context of cashmere fineness in goats, KRT79 shows a positive regulatory effect as verified by PRM technology [2]. In the hair follicle development, K79+ cells at the distal tips of columns change shape, recede, and undergo cell death during late embryogenesis and early postnatal development, creating an orifice for hair emergence [3].
In conclusion, Krt79 plays important roles in skin and hair follicle development, as well as in liver response to damage. Studies in mouse models have revealed its regulatory mechanisms and potential as a biomarker, contributing to our understanding of related biological processes and disease conditions.
References：
1. Kim, Donghwan, Choi, Inwook, Ha, Sang Keun, Gonzalez, Frank J. 2023. Keratin 79 is a PPARA target that is highly expressed by liver damage. In Biochemical and biophysical research communications, 650, 132-136. doi:10.1016/j.bbrc.2023.01.071. https://pubmed.ncbi.nlm.nih.gov/36796223/
2. Xu, Yanan, Zhang, Yu, Qin, Yuting, Li, Shuaitong, Wang, Zeying. 2023. Multi-omics analysis of functional substances and expression verification in cashmere fineness. In BMC genomics, 24, 720. doi:10.1186/s12864-023-09825-0. https://pubmed.ncbi.nlm.nih.gov/38017403/
3. Mesler, Arlee L, Benedeck, Rachel E, Wong, Sunny Y. 2020. Preparing the hair follicle canal for hair shaft emergence. In Experimental dermatology, 30, 472-478. doi:10.1111/exd.14210. https://pubmed.ncbi.nlm.nih.gov/33025661/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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