C57BL/6JCya-Sfnem1/Cya
Common Name
Sfn-KO
Product ID
S-KO-18523
Backgroud
C57BL/6JCya
Strain ID
KOCMP-55948-Sfn-B6J-VA
When using this mouse strain in a publication, please cite “Sfn-KO Mouse (Catalog S-KO-18523) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Sfn-KO
Strain ID
KOCMP-55948-Sfn-B6J-VA
Gene Name
Product ID
S-KO-18523
Gene Alias
14-3-3, Er, Mme1, Ywhas
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 4
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000057311
NCBI RefSeq
NM_018754
Target Region
Exon 1
Size of Effective Region
~2.8 kb
Overview of Gene Research
Sfn, which stands for Sulforaphane, is a phytocompound belonging to the isothiocyanate family. It is mainly present in sprouts of cruciferous vegetables like broccoli and cabbage. SFN is produced from glucoraphanin by the action of myrosinase. It is well-known for its antioxidant, anti-inflammatory, and anti-apoptotic properties. These properties suggest its potential in various biological processes and disease prevention [1,2].
SFN has been studied for its effects in multiple disease conditions. In neurodegenerative diseases such as Alzheimer's, Parkinson's, and multiple sclerosis, its beneficial effects suggest it could be a useful supplement [1]. In cervical cancer cells, it enhances radiosensitivity by activating LATS2 and blocking Rad51/MDC1 recruitment to the DNA damage site [3]. For psoriasis, it alleviates symptoms through KEAP1-NRF2 pathway activation and attenuation of inflammatory signaling [4].
In conclusion, Sfn exhibits a wide range of biological functions mainly due to its antioxidant, anti-inflammatory, and anti-apoptotic properties. Its study in various disease models, including those related to neurodegenerative diseases, cancer, and psoriasis, has provided insights into its potential therapeutic applications. Understanding Sfn may offer new strategies for treating these diseases.
References：
1. Schepici, Giovanni, Bramanti, Placido, Mazzon, Emanuela. 2020. Efficacy of Sulforaphane in Neurodegenerative Diseases. In International journal of molecular sciences, 21, . doi:10.3390/ijms21228637. https://pubmed.ncbi.nlm.nih.gov/33207780/
2. Otoo, Raymond A, Allen, Antiño R. 2023. Sulforaphane's Multifaceted Potential: From Neuroprotection to Anticancer Action. In Molecules (Basel, Switzerland), 28, . doi:10.3390/molecules28196902. https://pubmed.ncbi.nlm.nih.gov/37836745/
3. Wang, Shiyu, Wang, Yanan, Liu, Xiangnan, Wu, Sufang, Liu, Yuan. 2022. SFN Enhanced the Radiosensitivity of Cervical Cancer Cells via Activating LATS2 and Blocking Rad51/MDC1 Recruitment to DNA Damage Site. In Cancers, 14, . doi:10.3390/cancers14081872. https://pubmed.ncbi.nlm.nih.gov/35454780/
4. Ma, Chujun, Gu, Chaode, Lian, Panpan, Lu, Yan, Su, Zhonglan. 2023. Sulforaphane alleviates psoriasis by enhancing antioxidant defense through KEAP1-NRF2 Pathway activation and attenuating inflammatory signaling. In Cell death & disease, 14, 768. doi:10.1038/s41419-023-06234-9. https://pubmed.ncbi.nlm.nih.gov/38007430/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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