C57BL/6JCya-Mcemp1em1/Cya
Common Name:
Mcemp1-KO
Product ID:
S-KO-18542
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Mcemp1-KO
Strain ID
KOCMP-69189-Mcemp1-B6J-VB
Gene Name
Product ID
S-KO-18542
Gene Alias
1810033B17Rik
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
8
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Mcemp1em1/Cya mice (Catalog S-KO-18542) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000014118
NCBI RefSeq
NM_026985
Target Region
Exon 3~7
Size of Effective Region
~3.1 kb
Detailed Document
Overview of Gene Research
MCEMP1, also known as C19ORF59, is a gene with diverse functions. It functions as an adaptor for KIT, promoting SCF-mediated mast cell proliferation, and is involved in immune-related signaling pathways [1,2]. It may also participate in the regulation of cell chemotaxis, adhesion, and migration, especially in a TGFβ-dependent manner [4].
In lung-specific contexts, Mcemp1-deficient mice exhibit reduced airway inflammation and lung impairment in chronic asthma models, indicating its role in promoting mast cell-related inflammation [1]. In idiopathic pulmonary fibrosis, MCEMP1 is highly expressed in circulating classical monocytes and alveolar macrophages, and may regulate the migration and transition of monocytes during fibrosis development [4]. In septic shock, MCEMP1 was identified as one of six hub genes with diagnostic value [3]. In stroke, peripheral blood MCEMP1 gene expression may be useful for diagnosis and as a prognostic biomarker [5].
In conclusion, MCEMP1 is involved in multiple biological processes, especially those related to immune-cell regulation and disease-related inflammation. The use of gene-knockout mouse models, such as in the study of asthma, has revealed its role in promoting disease-related processes. Its potential as a biomarker in diseases like septic shock and stroke further emphasizes its importance in biomedical research.
References：
1. Choi, Youn Jung, Yoo, Ji-Seung, Jung, Kyle, Asosingh, Kewal, Jung, Jae U. 2023. Lung-specific MCEMP1 functions as an adaptor for KIT to promote SCF-mediated mast cell proliferation. In Nature communications, 14, 2045. doi:10.1038/s41467-023-37873-3. https://pubmed.ncbi.nlm.nih.gov/37041174/
2. Wang, Daijun, Gu, Yanmei, Huo, Chengdong, Teng, Muzhou, Li, Yumin. 2022. MCEMP1 is a potential therapeutic biomarker associated with immune infiltration in advanced gastric cancer microenvironment. In Gene, 840, 146760. doi:10.1016/j.gene.2022.146760. https://pubmed.ncbi.nlm.nih.gov/35905854/
3. Kong, Chang, Zhu, Yurun, Xie, Xiaofan, Wu, Jiayu, Qian, Meizi. 2023. Six potential biomarkers in septic shock: a deep bioinformatics and prospective observational study. In Frontiers in immunology, 14, 1184700. doi:10.3389/fimmu.2023.1184700. https://pubmed.ncbi.nlm.nih.gov/37359526/
4. Perrot, Carole Y, Karampitsakos, Theodoros, Unterman, Avraham, Bandyopadhyay, Debabrata, Herazo-Maya, Jose D. 2023. Mast-Cell Expressed Membrane Protein-1 (MCEMP1) is expressed in classical monocytes and alveolar macrophages in Idiopathic Pulmonary Fibrosis and regulates cell chemotaxis, adhesion, and migration in a TGFβ dependent manner. In bioRxiv : the preprint server for biology, , . doi:10.1101/2023.10.07.561349. https://pubmed.ncbi.nlm.nih.gov/37873485/
5. Raman, Kripa, O'Donnell, Martin J, Czlonkowska, Anna, Yusuf, Salim, Paré, Guillaume. 2016. Peripheral Blood MCEMP1 Gene Expression as a Biomarker for Stroke Prognosis. In Stroke, 47, 652-8. doi:10.1161/STROKEAHA.115.011854. https://pubmed.ncbi.nlm.nih.gov/26846866/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen