C57BL/6JCya-Zfp740em1/Cya
Common Name
Zfp740-KO
Product ID
S-KO-18549
Backgroud
C57BL/6JCya
Strain ID
KOCMP-68744-Zfp740-B6J-VB
When using this mouse strain in a publication, please cite “Zfp740-KO Mouse (Catalog S-KO-18549) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Zfp740-KO
Strain ID
KOCMP-68744-Zfp740-B6J-VB
Gene Name
Product ID
S-KO-18549
Gene Alias
1110034O07Rik, Znf740
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 15
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000119800
NCBI RefSeq
NM_001289695
Target Region
Exon 3~6
Size of Effective Region
~2.7 kb
Overview of Gene Research
Zfp740, whose specific aliases are not given in the provided content, is involved in the regulation of memory NK cell persistence. It is part of the Themis2-Zfp740 pathway, where Themis2 translocates to the nucleus to promote Zfp740-mediated repression [1].
In Zfp740-deficient mice, an increase in the number of memory NK cells and enhancement of their effector function were observed. This indicates that Zfp740 negatively regulates the number and effector function of memory NK cells, revealing its importance in the process of memory NK cell differentiation and function [1].
In conclusion, Zfp740 is a key regulator in the formation and function of memory NK cells. The Zfp740-deficient mouse model has been crucial in demonstrating its role in this aspect of the immune response, providing insights into the molecular mechanisms of NK cell-related immunological processes.
References：
1. Nabekura, Tsukasa, Deborah, Elfira Amalia, Tahara, Saeko, Muratani, Masafumi, Shibuya, Akira. 2023. Themis2 regulates natural killer cell memory function and formation. In Nature communications, 14, 7200. doi:10.1038/s41467-023-42578-8. https://pubmed.ncbi.nlm.nih.gov/37938555/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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