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C57BL/6JCya-Rap1gapem1/Cya
Common Name:
Rap1gap-KO
Product ID:
S-KO-18569
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Rap1gap-KO
Strain ID
KOCMP-110351-Rap1gap-B6J-VB
Gene Name
Rap1gap
Product ID
S-KO-18569
Gene Alias
1300019I11Rik; 2310004O14Rik; ARPP-90; Gap; Rap1GAP1; Rap1ga1
Background
C57BL/6JCya
NCBI ID
110351
Modification
Conventional knockout
Chromosome
4
Phenotype
MGI:109338
Document
Click here to download >>
Application
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More
Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Rap1gapem1/Cya mice (Catalog S-KO-18569) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000105835
NCBI RefSeq
NM_001256218
Target Region
Exon 11~17
Size of Effective Region
~4.0 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Rap1gap, short for Rap1 GTPase-activating protein, is an important tumor suppressor. It is involved in regulating the GTP-GDP form switch of Rap1, a monomeric GTPase of the Ras family. Rap1gap is associated with multiple signaling pathways such as the AMPK/SIRT1/NF-κB and AMPK/AKT/mTOR pathways, playing a role in various biological processes like cell-matrix adhesion, autophagy, and oxidative stress regulation [1,2,6]. Genetic models, especially knockout (KO) and conditional knockout (CKO) mouse models, have been crucial in studying its functions.

In cardiac-specific Rap1GAP-CKO mice, after myocardial infarction (MI), the hearts showed alleviated apoptosis, inflammation, infarct size, and left ventricular dysfunction compared to control mice. Rap1GAP was found to inhibit the AMPK/SIRT1 pathway and activate the NF-κB signaling pathway, exacerbating the damage to myocardial cells caused by ischemia and hypoxia [1]. In another study, in rats infused with Ang II, overexpression of Rap1GAP in cardiomyocytes exacerbated Ang II-induced cardiomyocyte hypertrophy, ROS generation, and cell apoptosis, while inhibiting autophagy. Knockdown of Rap1GAP by siRNA attenuated these effects and activated the AMPK/AKT/mTOR signaling pathway [2].

In conclusion, Rap1gap is a significant gene involved in multiple biological functions and disease-related processes. Studies using KO/CKO mouse models have revealed its role in myocardial infarction and cardiomyocyte hypertrophy, highlighting its potential as a therapeutic target in these cardiac-related disease areas. Additionally, it may also play a role in endometriosis, endometrial cancer, leukemia, and thyroid cancer, as changes in its expression have been associated with these diseases [3,4,7,5,8,9].

References:
1. Shan, Tiantian, Li, Xiaoying, Xie, Wenzhi, Li, Ying, Zhao, Zhuo. 2024. Rap1GAP exacerbates myocardial infarction by regulating the AMPK/SIRT1/NF-κB signaling pathway. In Cellular signalling, 117, 111080. doi:10.1016/j.cellsig.2024.111080. https://pubmed.ncbi.nlm.nih.gov/38320624/
2. Gao, Yan, Zhao, Di, Xie, Wen-Zhi, Bi, Xiuping, Zhao, Zhuo. 2021. Rap1GAP Mediates Angiotensin II-Induced Cardiomyocyte Hypertrophy by Inhibiting Autophagy and Increasing Oxidative Stress. In Oxidative medicine and cellular longevity, 2021, 7848027. doi:10.1155/2021/7848027. https://pubmed.ncbi.nlm.nih.gov/33936386/
3. Dehghanian, Mehran, Yarahmadi, Ghafour, Sandoghsaz, Reyhaneh Sadat, Shamsi, Farimah, Vahidi Mehrjardi, Mohammad Yahya. 2023. Evaluation of Rap1GAP and EPAC1 Gene Expression in Endometriosis Disease. In Advanced biomedical research, 12, 101. doi:10.4103/abr.abr_86_22. https://pubmed.ncbi.nlm.nih.gov/37288024/
4. Tamate, Masato, Tanaka, Ryoichi, Osogami, Hiroyuki, Iwasaki, Masahiro, Saito, Tsuyoshi. 2017. Rap1GAP inhibits tumor progression in endometrial cancer. In Biochemical and biophysical research communications, 485, 476-483. doi:10.1016/j.bbrc.2017.02.044. https://pubmed.ncbi.nlm.nih.gov/28196746/
5. Faam, Bita, Ghaffari, Mohammad A, Khorsandi, Layasadat, Shahbazian, Hajeih B, Hashemi Tabar, Mahmoud. 2021. RAP1GAP Functions as a Tumor Suppressor Gene and Is Regulated by DNA Methylation in Differentiated Thyroid Cancer. In Cytogenetic and genome research, 161, 227-235. doi:10.1159/000516122. https://pubmed.ncbi.nlm.nih.gov/34311462/
6. Vuchak, Lisa A, Tsygankova, Oxana M, Meinkoth, Judy L. 2011. Rap1GAP impairs cell-matrix adhesion in the absence of effects on cell-cell adhesion. In Cell adhesion & migration, 5, 323-31. doi:. https://pubmed.ncbi.nlm.nih.gov/21785277/
7. Qiu, Tingting, Qi, Xiaofei, Cen, Jiannong, Chen, Zixing. 2012. Rap1GAP alters leukemia cell differentiation, apoptosis and invasion in vitro. In Oncology reports, 28, 622-8. doi:10.3892/or.2012.1825. https://pubmed.ncbi.nlm.nih.gov/22614916/
8. Faam, Bita, Ghadiri, Ata A, Ghaffari, Mohammad Ali, Fanaei, Seyed Ahmad, Khorsandi, Layasadat. 2022. CpG Island Methylation of the Rap1Gap Gene in Medullary Thyroid Cancer. In Archives of Iranian medicine, 25, 171-177. doi:10.34172/aim.2022.29. https://pubmed.ncbi.nlm.nih.gov/35429959/
9. Dong, Xiaoyun, Tang, Waixing, Stopenski, Stephen, Korch, Christopher, Meinkoth, Judy L. 2012. RAP1GAP inhibits cytoskeletal remodeling and motility in thyroid cancer cells. In Endocrine-related cancer, 19, 575-88. doi:10.1530/ERC-12-0086. https://pubmed.ncbi.nlm.nih.gov/22696507/
Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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