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C57BL/6JCya-Lrp11em1/Cya
Common Name:
Lrp11-KO
Product ID:
S-KO-18572
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Lrp11-KO
Strain ID
KOCMP-237253-Lrp11-B6J-VB
Gene Name
Lrp11
Product ID
S-KO-18572
Gene Alias
1700034J19Rik; 6330533B21; 9830160H19Rik
Background
C57BL/6JCya
NCBI ID
237253
Modification
Conventional knockout
Chromosome
10
Phenotype
MGI:2442989
Document
Click here to download >>
Application
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Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Lrp11em1/Cya mice (Catalog S-KO-18572) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000019931
NCBI RefSeq
NM_172784
Target Region
Exon 1~5
Size of Effective Region
~15.1 kb
Detailed Document
Click here to download >>
Overview of Gene Research
LRP11, also known as low density lipoprotein receptor-related protein 11, is involved in multiple biological processes. It plays a role in lipid metabolism-related pathways as it has been associated with cholesterol homeostasis, and is important in tumor-related biological functions and immune-related mechanisms [2,3].

In tumor-related research, LRP11 has been found to have diverse effects. In prostate cancer, it activates β-catenin to induce PD-L1 expression, which may help tumor cells evade immune attack [2]. In hepatocellular carcinoma, knockdown of LRP11 reduces lipid accumulation and decreases key lipid metabolism markers, suggesting its role in facilitating lipid metabolism and malignancy in this cancer type [3]. In cervical cancer, it is highly expressed and acts as a risk prognostic factor, and is involved in multiple tumor-malignant pathways, with high-expressing patients potentially having an immune-desert tumor microenvironment and drug resistance [4]. In the context of immunotherapy, LRP11 promotes stem-like T cells via MAPK13-mediated TCF1 phosphorylation, enhancing anti-PD1 immunotherapy. LDL-induced LRP11 activation can increase stem-like T cells and enhance antitumor immunity [1].

In conclusion, LRP11 is crucial in lipid metabolism and tumor-related biological processes. Its role in promoting stem-like T cells has implications for immunotherapy, and its functions in various cancers, such as prostate, hepatocellular, and cervical cancers, make it a potential therapeutic target in oncology research.

References:
1. Sun, Lingjuan, Ma, Zhibo, Zhao, Xiangli, Chen, Gang, Lan, Peixiang. 2024. LRP11 promotes stem-like T cells via MAPK13-mediated TCF1 phosphorylation, enhancing anti-PD1 immunotherapy. In Journal for immunotherapy of cancer, 12, . doi:10.1136/jitc-2023-008367. https://pubmed.ncbi.nlm.nih.gov/38272565/
2. Gan, Sishun, Ye, Jianqing, Li, Jian, Qu, Fajun, Cui, Xingang. 2019. LRP11 activates β-catenin to induce PD-L1 expression in prostate cancer. In Journal of drug targeting, 28, 508-515. doi:10.1080/1061186X.2019.1687710. https://pubmed.ncbi.nlm.nih.gov/31865764/
3. Liang, Litao, Jia, Wenbo, Wang, Jinyi, Kong, Lianbao, Ding, Wenzhou. 2025. LRP11 facilitates lipid metabolism and malignancy in hepatocellular carcinoma by stabilizing RACK1 through USP5 regulation. In Molecular medicine (Cambridge, Mass.), 31, 35. doi:10.1186/s10020-025-01097-6. https://pubmed.ncbi.nlm.nih.gov/39891099/
4. Gu, Fangyun, Xu, Fang, Pan, Zimeng, Huang, ShuFeng, Sun, Miao. . An integrative pan-cancer analysis illustrating the key role of LRP11 in cervical cancer. In Medicine, 102, e33201. doi:10.1097/MD.0000000000033201. https://pubmed.ncbi.nlm.nih.gov/36930084/
Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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