C57BL/6JCya-H1f1em1/Cya
Common Name
H1f1-KO
Product ID
S-KO-18588
Backgroud
C57BL/6JCya
Strain ID
KOCMP-80838-H1f1-B6J-VA
When using this mouse strain in a publication, please cite “H1f1-KO Mouse (Catalog S-KO-18588) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
H1f1-KO
Strain ID
KOCMP-80838-H1f1-B6J-VA
Gene Name
Product ID
S-KO-18588
Gene Alias
H1-1, H1.1, H1a, H1var3, Hist1h1a
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 13
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000055770
NCBI RefSeq
NM_030609
Target Region
Exon 1
Size of Effective Region
~2.0 kb
Overview of Gene Research
H1f1 is a gene whose specific functions and aliases are not elaborated in the provided references. However, it is involved in the H1F1 signaling pathway which was found to be aberrantly regulated in the endometrium of intrauterine adhesion (IUA) patients. This indicates its potential importance in the molecular mechanisms related to IUA [1].
There is no information regarding gene knockout (KO) or conditional knockout (CKO) mouse models in the provided references.
In conclusion, while the exact function of H1f1 remains to be fully explored, its association with the aberrantly regulated H1F1 signaling pathway in IUA endometrium suggests its significance in the context of IUA. Further functional studies, potentially including KO or CKO mouse models, could help to better understand its role in this and potentially other disease conditions.
References：
1. Gao, Linzhi, Liang, Enming, Zhang, Dong, Wang, Xiaoyu, Shen, Yuan. 2023. Epigenetic alternations and targeted therapy in intrauterine adhesion: A comparative study. In Genomics, 115, 110673. doi:10.1016/j.ygeno.2023.110673. https://pubmed.ncbi.nlm.nih.gov/37385390/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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