C57BL/6JCya-Jak3em1/Cya
Common Name:
Jak3-KO
Product ID:
S-KO-18620
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Jak3-KO
Strain ID
KOCMP-16453-Jak3-B6J-VB
Gene Name
Product ID
S-KO-18620
Gene Alias
fae; wil
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
8
Phenotype
Document
Application
--
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Jak3em1/Cya mice (Catalog S-KO-18620) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000051995
NCBI RefSeq
NM_010589
Target Region
Exon 7~17
Size of Effective Region
~4.8 kb
Detailed Document
Overview of Gene Research
Jak3, a member of the Janus kinase (JAK) family, is a non-receptor tyrosine kinase. It is mainly expressed in hematopoietic tissue cells and is uniquely associated with cytokines shared in the common gamma-chain receptor subunit. Jak3 plays a crucial role in immune regulation by activating the signal transducer and activator of transcription (STAT) proteins, thereby participating in multiple cytokine-mediated signaling pathways [4].
JAK3 inhibitors have shown potential in treating various inflammatory and autoimmune diseases. For example, PF-06651600, an irreversible JAK3 inhibitor, can also inhibit five TEC kinase family members due to a unique cysteine residue (Cys-909) in JAK3's catalytic domain. This dual inhibition may provide a beneficial inhibitory profile for diseases like rheumatoid arthritis, inflammatory bowel disease, alopecia areata, and vitiligo [1]. A JAK3 inhibitor can suppress multipotent ILC2s and attenuate steroid-resistant asthma, as the JAK3/STAT pathways contribute to the acquisition of steroid-resistant ILC2s [2]. Ritlecitinib, an oral JAK3/TEC family kinase inhibitor, downregulated immune biomarkers and upregulated melanocyte-related markers in vitiligo patients [3].
In conclusion, Jak3 is essential for immune-related functions through its role in cytokine-mediated signaling. The use of JAK3 inhibitors in pre-clinical and clinical studies has demonstrated their potential in treating inflammatory and autoimmune diseases such as rheumatoid arthritis, steroid-resistant asthma, and vitiligo, highlighting the importance of Jak3 as a therapeutic target in these disease areas.
References:
1. Xu, Hua, Jesson, Michael I, Seneviratne, Uthpala I, Kilty, Iain, Telliez, Jean-Baptiste. 2019. PF-06651600, a Dual JAK3/TEC Family Kinase Inhibitor. In ACS chemical biology, 14, 1235-1242. doi:10.1021/acschembio.9b00188. https://pubmed.ncbi.nlm.nih.gov/31082193/
2. Kim, Jihyun, Ham, Jongho, Kang, Hye Ryun, Kim, TaeSoo, Kim, Hye Young. 2023. JAK3 inhibitor suppresses multipotent ILC2s and attenuates steroid-resistant asthma. In Science advances, 9, eadi3770. doi:10.1126/sciadv.adi3770. https://pubmed.ncbi.nlm.nih.gov/38117887/
3. Guttman-Yassky, Emma, Del Duca, Ester, Da Rosa, Joel Correa, Yamaguchi, Yuji, Peeva, Elena. 2023. Improvements in immune/melanocyte biomarkers with JAK3/TEC family kinase inhibitor ritlecitinib in vitiligo. In The Journal of allergy and clinical immunology, 153, 161-172.e8. doi:10.1016/j.jaci.2023.09.021. https://pubmed.ncbi.nlm.nih.gov/37777018/
4. Chen, Chengjuan, Lu, Dianxiang, Sun, Tao, Zhang, Tiantai. 2022. JAK3 inhibitors for the treatment of inflammatory and autoimmune diseases: a patent review (2016-present). In Expert opinion on therapeutic patents, 32, 225-242. doi:10.1080/13543776.2022.2023129. https://pubmed.ncbi.nlm.nih.gov/34949146/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen