C57BL/6JCya-Napgem1/Cya
Common Name:
Napg-KO
Product ID:
S-KO-18628
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
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Basic Information
Strain Name
Napg-KO
Strain ID
KOCMP-108123-Napg-B6J-VB
Gene Name
Product ID
S-KO-18628
Gene Alias
2400003O04Rik; SNARE
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
18
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Napgem1/Cya mice (Catalog S-KO-18628) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000025474
NCBI RefSeq
NM_028017
Target Region
Exon 2~11
Size of Effective Region
~16.4 kb
Detailed Document
Overview of Gene Research
Napg, encoding gamma-SNAP (soluble N-ethylmaleimide-sensitive fusion (NSF)-attachment protein gamma), is located on chromosome 18p11. It is thought to play a role in cellular processes required for neurotransmission in the central nervous system [5].
A study on a large Chinese pedigree with hereditary hemorrhagic telangiectasia (HHT) identified a mutation (c.784A > G) in Napg that co-segregated with the disease. Functional prediction showed this mutation was deleterious and might change the conformational stability of the Napg protein, potentially leading to HHT [1]. Association studies in the Chinese Han population found that certain SNPs in Napg were associated with bipolar disorder, with haplotypes also showing associations, supporting Napg as a candidate for susceptibility to bipolar disorder [2]. In fetal growth restriction (FGR), the expression of Napg was up-regulated in newborn umbilical cord blood, maternal serum, and placental tissue, and Spearman correlation analysis indicated its potential role as a mediator in the communication between the gut and circulatory system in FGR [3]. Mendelian randomization analysis suggested that Napg in prostate tissue could be a potential drug target for prostate cancer, while a phenome-wide association study showed possible side effects if used as a drug target [4].
In summary, Napg appears to be involved in multiple biological processes and disease conditions. Its role in neurotransmission-related processes, as well as its associations with HHT, bipolar disorder, FGR, and prostate cancer, highlight its importance in understanding these biological functions and disease mechanisms. The genetic studies on Napg contribute to a better understanding of the molecular etiology of these diseases, potentially providing new directions for disease prevention and treatment.
References:
1. Xu, Yu, Zhang, Yong-Biao, Liang, Li-Jun, Gu, Ming-Liang, Gao, Zhan-Cheng. 2021. NAPG mutation in family members with hereditary hemorrhagic telangiectasia in China. In BMC pulmonary medicine, 21, 197. doi:10.1186/s12890-021-01524-4. https://pubmed.ncbi.nlm.nih.gov/34112136/
2. Li, Xingwang, Zhang, Jing, Wang, Yang, He, Lin, He, Guang. 2009. Association study on the NAPG gene and bipolar disorder in the Chinese Han population. In Neuroscience letters, 457, 159-62. doi:10.1016/j.neulet.2009.03.070. https://pubmed.ncbi.nlm.nih.gov/19429185/
3. Tang, Hui, Li, Dan, Peng, Jing, Zhang, Xian, Li, Hanmei. 2024. Potential Association of Gut Microbial Metabolism and Circulating mRNA Based on Multiomics Sequencing Analysis in Fetal Growth Restriction. In Mediators of inflammation, 2024, 9986187. doi:10.1155/2024/9986187. https://pubmed.ncbi.nlm.nih.gov/38716374/
4. Cheng, Long, Qiu, Zeming, Wu, Xuewu, Dong, Zhilong. 2024. Evaluation of circulating plasma proteins in prostate cancer using mendelian randomization. In Discover oncology, 15, 453. doi:10.1007/s12672-024-01331-3. https://pubmed.ncbi.nlm.nih.gov/39287922/
5. Weller, Andrew E, Dahl, John P, Lohoff, Falk W, Ferraro, Thomas N, Berrettini, Wade H. . Analysis of variations in the NAPG gene on chromosome 18p11 in bipolar disorder. In Psychiatric genetics, 16, 3-8. doi:. https://pubmed.ncbi.nlm.nih.gov/16395123/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen