Logo
Homepage
Explore Our Models
My Cart
Contact
Subscribe
Models
Genetically Engineered Animals
Knockout Mice
Knockout Rats
Knockin Mice
Knockin Rats
Transgenic Mice
Transgenic Rats
Model Generation Techniques
Turboknockout<sup>®</sup> Gene Targeting
ES Cell Gene Targeting
Targeted Gene Editing
Regular Transgenic
PiggyBac Transgenesis
BAC Transgenic
Research Models
HUGO-GT™ Humanized Mice
Cre Mouse Lines
Humanized Target Gene Models
Metabolic Disease Models
Ophthalmic Disease Models
Neurological Disease Models
Autoimmune Disease Models
Immunodeficient Mouse Models
Humanized Immune System Mouse Models
Oncology & Immuno-oncology Models
Covid-19 Mouse Models
MouseAtlas Model Library
Knockout Cell Line Product Catalog
Tumor Cell Line Product Catalog
AAV Standard Product Catalog
Animal Supporting Services
Breeding Services
Cryopreservation & Recovery
Phenotyping Services
BAC Modification
Custom Cell Line Models
Induced Pluripotent Stem Cells (iPSCs)
Knockout Cell Lines
Knockin Cell Lines
Point Mutation Cell Lines
Overexpression Cell Lines
Virus Packaging
Adeno-associated Virus (AAV) Packaging
Lentivirus Packaging
Adenovirus Packaging
CRO Services
By Therapeutic Area
Oncology
Ophthalmology
Neuroscience
Metabolic & Cardiovascular Diseases
Autoimmune & Inflammatory
By Drug Type
AI-Powered AAV Discovery
Gene Therapy
Oligonucleotide Therapy
Antibody Therapy
Cell Immunotherapy
Resources
Promotion
Events & Webinars
Newsroom
Blogs & Insights
Resource Vault
Reference Databases
Peer-Reviewed Citations
Rare Disease Data Center
AbSeek
Cell iGeneEditor™ System
OriCell
Quality
Facility Overview
Animal Health & Welfare
Health Reports
About Us
Corporate Overview
Our Partners
Careers
Contact Us
Login
Request a Product Quote
Select products from our catalogs and submit your request. Our team will get back to you with detailed information.
Full Name
Email
Phone Number
Organization
Job Role
Country
Catalog Type
Product Name
Additional Comments
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.
C57BL/6NCya-Ppiaem1/Cya
Common Name:
Ppia-KO
Product ID:
S-KO-18715
Background:
C57BL/6NCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Ppia-KO
Strain ID
KOCMP-268373-Ppia-B6N-VA
Gene Name
Ppia
Product ID
S-KO-18715
Gene Alias
Cphn; CyP-18; CypA; SP18
Background
C57BL/6NCya
NCBI ID
268373
Modification
Conventional knockout
Chromosome
11
Phenotype
MGI:97749
Document
Click here to download >>
Application
--
More
Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6NCya-Ppiaem1/Cya mice (Catalog S-KO-18715) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000132846
NCBI RefSeq
NM_008907
Target Region
Exon 1~5
Size of Effective Region
~7.3 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Ppia, also known as peptidylprolyl isomerase A or cyclophilin A, is a central enzyme in the protein-folding response pathway [3]. It has peptidyl-prolyl cis/trans isomerase activity, which can catalyze the cis-trans isomerization of peptidyl-prolyl bonds in proteins, thus playing a crucial role in protein folding, assembly, and transport. Ppia is involved in multiple biological pathways and is important for normal cellular function [5].

In lung cancer, ablation of Ppia promotes NRF2 protein degradation and blocks NRF2-driven growth, indicating its role in promoting lung cancer progression [1]. Ppia -/- mice have significantly less fat and smaller adipocytes, and silencing Ppia in cell lines impairs adipocyte differentiation, suggesting it is a novel adipogenic factor in obesity [2]. In multiple myeloma, CRISPR-Cas9 deletion of PPIA or its inhibition with a small molecule inhibitor sensitizes tumor cells to proteasome inhibitors, highlighting it as a potential therapeutic target [3]. In oral cancer, reducing PPIA expression and secretion decreases cell invasion and migration, while recombinant PPIA treatment increases these processes, suggesting it may be a novel target and prognostic marker [4].

In conclusion, Ppia is essential for protein-folding-related functions and is involved in various disease-related biological processes. Studies using gene-knockout models, such as Ppia -/- mice, have revealed its role in cancer progression, obesity, and multiple myeloma, providing valuable insights into potential therapeutic strategies for these diseases.

References:
1. Lu, Weiqiang, Cui, Jiayan, Wang, Wanyan, Ji, Hongbin, Huang, Jin. 2024. PPIA dictates NRF2 stability to promote lung cancer progression. In Nature communications, 15, 4703. doi:10.1038/s41467-024-48364-4. https://pubmed.ncbi.nlm.nih.gov/38830868/
2. Zhang, Lihong, Li, Zhen, Zhang, Bo, He, Haiyang, Bai, Yun. 2015. PPIA is a novel adipogenic factor implicated in obesity. In Obesity (Silver Spring, Md.), 23, 2093-100. doi:10.1002/oby.21208. https://pubmed.ncbi.nlm.nih.gov/26347493/
3. Cohen, Yael C, Zada, Mor, Wang, Shuang-Yin, Weiner, Assaf, Amit, Ido. 2021. Identification of resistance pathways and therapeutic targets in relapsed multiple myeloma patients through single-cell sequencing. In Nature medicine, 27, 491-503. doi:10.1038/s41591-021-01232-w. https://pubmed.ncbi.nlm.nih.gov/33619369/
4. Liao, En-Chi, Law, Ching-Hsuan, Chen, Hsin-Yi, Chou, Hsiu-Chuan, Chan, Hong-Lin. 2025. PPIA enhances cell growth and metastasis through CD147 in oral cancer. In Archives of biochemistry and biophysics, 765, 110328. doi:10.1016/j.abb.2025.110328. https://pubmed.ncbi.nlm.nih.gov/39921142/
5. Trémillon, Nicolas, Morello, Eric, Llull, Daniel, Ginisty, Hervé, Poquet, Isabelle. 2012. PpiA, a surface PPIase of the cyclophilin family in Lactococcus lactis. In PloS one, 7, e33516. doi:10.1371/journal.pone.0033516. https://pubmed.ncbi.nlm.nih.gov/22442694/
Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
Model Library
Model Library
Resources
Resources
Animal Quality
Animal Quality
Get Support
Get Support
Address:
2255 Martin Avenue, Suite E Santa Clara, CA 95050-2709, US
Tel:
800-921-8930 (8-6pm PST)
+1408-963-0306 (lnt’l)
Fax:
408-969-0338
Email:
animal-service@cyagen.com
service@cyagen.us
CRO Services
OncologyOphthalmologyNeuroscienceMetabolic & CardiovascularAutoimmune & InflammatoryGene TherapyAntibody Therapy
About Us
Corporate OverviewOur PartnersCareersContact Us
Social Media
Disclaimer: Pricing and availability of our products and services vary by region. Listed prices are applicable to the specific countries. Please contact us for more information.
Copyright © 2025 Cyagen. All rights reserved.
Privacy Policy
Site Map
Stay Updated with the Latest from Cyagen
Get the latest news on our research models, CRO services, scientific resources, and special offers—tailored to your research needs and delivered straight to your inbox.
Full Name
Email
Organization
Country
Areas of Interest