C57BL/6JCya-Ifi207em1/Cya
Common Name
Ifi207-KO
Product ID
S-KO-18757
Backgroud
C57BL/6JCya
Strain ID
KOCMP-226691-Ifi207-B6J-VB
When using this mouse strain in a publication, please cite “Ifi207-KO Mouse (Catalog S-KO-18757) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Ifi207-KO
Strain ID
KOCMP-226691-Ifi207-B6J-VB
Gene Name
Product ID
S-KO-18757
Gene Alias
Pyhin-A, pyhinA
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 1
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000042610
NCBI RefSeq
NM_001204910
Target Region
Exon 3
Size of Effective Region
~1.2 kb
Overview of Gene Research
Ifi207 is a member of the PYHIN and Alr gene families. It has a key role in innate immunity, being involved in cytokine promoter induction, and is associated with the STING-mediated pathway. It also contributes to host-pathogen interactions, with its study facilitated by genetic models like KO mouse models for understanding its functions [1,2,3].
Generation of Ifi207-/-mice demonstrated that IFI207 is not involved in autoimmunity. Instead, it is required for the establishment of Klebsiella pneumoniae lung infection and macrophage phagocytosis of Klebsiella [1]. In addition, in vivo studies show that IFI207 controls murine leukemia virus (MLV) infection, acting via the STING-mediated response to cGAMP, dsDNA, DMXXA, and MLV, by stabilizing STING protein through its repeat region [2,3].
In conclusion, Ifi207 is crucial for innate immune responses, playing diverse roles in host-pathogen interactions such as in bacterial and retroviral infections. The use of Ifi207 KO mouse models has been instrumental in uncovering its functions in these specific disease-relevant biological processes.
References：
1. Baran, Marcin, Feriotti, Claudia, McGinley, Aoife, Bengeochea, Jose A, Bowie, Andrew G. 2023. PYHIN protein IFI207 regulates cytokine transcription and IRF7 and contributes to the establishment of K. pneumoniae infection. In Cell reports, 42, 112341. doi:10.1016/j.celrep.2023.112341. https://pubmed.ncbi.nlm.nih.gov/37018072/
2. Moran, Eileen A, Salas-Briceno, Karen, Aguilera, Alexya N, Lilue, Jingtao, Ross, Susan R. 2023. IFI207, a young and fast-evolving antiviral factor, stabilizes STING. In bioRxiv : the preprint server for biology, , . doi:10.1101/2023.01.19.524411. https://pubmed.ncbi.nlm.nih.gov/36711784/
3. Moran, Eileen A, Salas-Briceno, Karen, Zhao, Wenming, Lilue, Jingtao, Ross, Susan R. 2024. IFI207, a young and fast-evolving protein, controls retroviral replication via the STING pathway. In mBio, 15, e0120924. doi:10.1128/mbio.01209-24. https://pubmed.ncbi.nlm.nih.gov/38860764/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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