C57BL/6JCya-Ifi207em1/Cya
Common Name:
Ifi207-KO
Product ID:
S-KO-18757
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Ifi207-KO
Strain ID
KOCMP-226691-Ifi207-B6J-VB
Gene Name
Product ID
S-KO-18757
Gene Alias
Pyhin-A; pyhinA
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
1
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Ifi207em1/Cya mice (Catalog S-KO-18757) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000042610
NCBI RefSeq
NM_001204910
Target Region
Exon 3
Size of Effective Region
~1.2 kb
Detailed Document
Overview of Gene Research
Ifi207 is a member of the PYHIN and Alr gene families. It has a key role in innate immunity, being involved in cytokine promoter induction, and is associated with the STING-mediated pathway. It also contributes to host-pathogen interactions, with its study facilitated by genetic models like KO mouse models for understanding its functions [1,2,3].
Generation of Ifi207-/-mice demonstrated that IFI207 is not involved in autoimmunity. Instead, it is required for the establishment of Klebsiella pneumoniae lung infection and macrophage phagocytosis of Klebsiella [1]. In addition, in vivo studies show that IFI207 controls murine leukemia virus (MLV) infection, acting via the STING-mediated response to cGAMP, dsDNA, DMXXA, and MLV, by stabilizing STING protein through its repeat region [2,3].
In conclusion, Ifi207 is crucial for innate immune responses, playing diverse roles in host-pathogen interactions such as in bacterial and retroviral infections. The use of Ifi207 KO mouse models has been instrumental in uncovering its functions in these specific disease-relevant biological processes.
References:
1. Baran, Marcin, Feriotti, Claudia, McGinley, Aoife, Bengeochea, Jose A, Bowie, Andrew G. 2023. PYHIN protein IFI207 regulates cytokine transcription and IRF7 and contributes to the establishment of K. pneumoniae infection. In Cell reports, 42, 112341. doi:10.1016/j.celrep.2023.112341. https://pubmed.ncbi.nlm.nih.gov/37018072/
2. Moran, Eileen A, Salas-Briceno, Karen, Aguilera, Alexya N, Lilue, Jingtao, Ross, Susan R. 2023. IFI207, a young and fast-evolving antiviral factor, stabilizes STING. In bioRxiv : the preprint server for biology, , . doi:10.1101/2023.01.19.524411. https://pubmed.ncbi.nlm.nih.gov/36711784/
3. Moran, Eileen A, Salas-Briceno, Karen, Zhao, Wenming, Lilue, Jingtao, Ross, Susan R. 2024. IFI207, a young and fast-evolving protein, controls retroviral replication via the STING pathway. In mBio, 15, e0120924. doi:10.1128/mbio.01209-24. https://pubmed.ncbi.nlm.nih.gov/38860764/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen