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C57BL/6JCya-Ddx47em1/Cya
Common Name:
Ddx47-KO
Product ID:
S-KO-18786
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Ddx47-KO
Strain ID
KOCMP-67755-Ddx47-B6J-VB
Gene Name
Ddx47
Product ID
S-KO-18786
Gene Alias
4930588A18Rik
Background
C57BL/6JCya
NCBI ID
67755
Modification
Conventional knockout
Chromosome
6
Phenotype
MGI:1915005
Document
Click here to download >>
Application
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Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Ddx47em1/Cya mice (Catalog S-KO-18786) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000032326
NCBI RefSeq
NM_026360
Target Region
Exon 3~5
Size of Effective Region
~1.8 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Ddx47, also known as DEAD-box helicase 47, is involved in RNA processing, cell division, and R-loop resolution. It plays a crucial role in maintaining genome stability and tissue homeostasis, and is associated with various biological processes and diseases [2,3,4]. It is part of the small subunit processome (SSUP) which mediates 18S rRNA biogenesis and is important for translational control in stem cells [5].

In lung adenocarcinoma, high expression of Ddx47 predicts a poor prognosis, and its knockdown reduces cell proliferation and migration in vitro, confirming its cancer-promoting effect [1]. In Locusta migratoria, knockdown of LmDDX47 (the ortholog of Ddx47) leads to midgut atrophy, a reduction in the number of regenerative and columnar cells, and increased cell death, indicating its role in maintaining midgut homeostasis [4]. It has also been identified as an R-loop resolvase, protecting cells from harmful R loops [3].

In conclusion, Ddx47 is essential for RNA-related processes, tissue homeostasis, and genome stability. Its study in model organisms like Locusta migratoria and in in vitro cancer cell models has revealed its role in promoting cancer cell proliferation and maintaining midgut integrity, which could provide insights into related disease mechanisms and potential treatment strategies.

References:
1. Chen, Yang, Zeng, Lizhong, Wang, Wei, Sun, Ruiying, Yang, Shuanying. 2022. DDX47 promotes cell proliferation and migration in lung adenocarcinoma. In Pathology, research and practice, 234, 153921. doi:10.1016/j.prp.2022.153921. https://pubmed.ncbi.nlm.nih.gov/35490652/
2. Yu, Zhenbao, Richard, Stéphane. 2023. DDX47 untangles R-loops with only certain other helicases. In Trends in cell biology, 33, 359-360. doi:10.1016/j.tcb.2023.03.001. https://pubmed.ncbi.nlm.nih.gov/36914533/
3. Marchena-Cruz, Esther, Camino, Lola P, Bhandari, Jay, Luna, Rosa, Aguilera, Andrés. 2023. DDX47, MeCP2, and other functionally heterogeneous factors protect cells from harmful R loops. In Cell reports, 42, 112148. doi:10.1016/j.celrep.2023.112148. https://pubmed.ncbi.nlm.nih.gov/36827184/
4. Wang, Jun-Xiu, Ma, En-Bo, Zhang, Jian-Zhen, Xing, Shu-Ping. 2022. DEAD-Box RNA Helicase DDX47 Maintains Midgut Homeostasis in Locusta migratoria. In International journal of molecular sciences, 23, . doi:10.3390/ijms23020586. https://pubmed.ncbi.nlm.nih.gov/35054771/
5. You, Kwon Tae, Park, Joha, Kim, V Narry. . Role of the small subunit processome in the maintenance of pluripotent stem cells. In Genes & development, 29, 2004-9. doi:10.1101/gad.267112.115. https://pubmed.ncbi.nlm.nih.gov/26443847/
Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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