C57BL/6JCya-Mnx1em1/Cya
Common Name:
Mnx1-KO
Product ID:
S-KO-18836
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
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Basic Information
Strain Name
Mnx1-KO
Strain ID
KOCMP-15285-Mnx1-B6J-VA
Gene Name
Product ID
S-KO-18836
Gene Alias
HB9; Hlxb9; MNR2
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
5
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Mnx1em1/Cya mice (Catalog S-KO-18836) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000165512
NCBI RefSeq
NM_019944
Target Region
Exon 2~3
Size of Effective Region
~2.8 kb
Detailed Document
Overview of Gene Research
Mnx1, or Motor neuron and pancreas homeobox 1, encodes a homeobox transcription factor crucial for pancreatic beta cell differentiation and development [1]. It is involved in pancreatic cancer subtypes, with pancreatic progenitor tumours preferentially expressing genes related to early pancreatic development including Mnx1 [2].
Mutations of the Mnx1 gene can cause permanent neonatal diabetes mellitus (PNDM), and such mutations may result in a range of extra-pancreatic features and a variable phenotype [1]. In lung adenocarcinoma, MnX1 is upregulated and facilitates the malignant progress by transcriptionally upregulating CCDC34, promoting cell proliferation, migration, invasion, and hindering apoptosis both in vitro and in vivo [3].
In conclusion, MnX1 is essential for pancreatic beta cell development and is associated with diseases like neonatal diabetes and cancer. The study of MnX1, potentially through gene knockout or conditional knockout mouse models in the future, can further reveal its role in these disease conditions, providing insights for disease treatment and prevention.
References：
1. Aly, Hanan Hassan, De Franco, Elisa, Flanagan, Sarah E, Elhenawy, Yasmine I. 2022. MNX1 mutations causing neonatal diabetes: Review of the literature and report of a case with extra-pancreatic congenital defects presenting in severe diabetic ketoacidosis. In Journal of diabetes investigation, 14, 516-521. doi:10.1111/jdi.13968. https://pubmed.ncbi.nlm.nih.gov/36586106/
2. Bailey, Peter, Chang, David K, Nones, Katia, Biankin, Andrew V, Grimmond, Sean M. 2016. Genomic analyses identify molecular subtypes of pancreatic cancer. In Nature, 531, 47-52. doi:10.1038/nature16965. https://pubmed.ncbi.nlm.nih.gov/26909576/
3. Wu, Junhua, Yue, Chongmei, Xu, Weiguo, Zhu, Jing, Li, Lin. 2023. MNX1 facilitates the malignant progress of lung adenocarcinoma through transcriptionally upregulating CCDC34. In Oncology letters, 26, 325. doi:10.3892/ol.2023.13911. https://pubmed.ncbi.nlm.nih.gov/37415626/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen