C57BL/6JCya-Fam114a1em1/Cya
Common Name:
Fam114a1-KO
Product ID:
S-KO-18864
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Fam114a1-KO
Strain ID
KOCMP-68303-Fam114a1-B6J-VA
Gene Name
Product ID
S-KO-18864
Gene Alias
1190001N04Rik; 9130005N14Rik; Noxp20
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
5
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Fam114a1em1/Cya mice (Catalog S-KO-18864) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000031080
NCBI RefSeq
NM_026667
Target Region
Exon 3
Size of Effective Region
~1.3 kb
Detailed Document
Overview of Gene Research
Fam114a1, Family with Sequence Similarity 114 Member A1, is a gene with diverse functions. It is involved in regulating angiotensin II signaling, which is crucial for cardiac pathological remodeling. It also appears to play roles in the biological activity of melanocytes, hepatocellular carcinoma development, and glomerular injury, and is associated with hypoxia response, Golgi enzyme recycling, and the host immune response to Helicobacter pylori infection [1,2,3,4,5,6,7].
In mouse models, homozygous KO of Fam114a1 (Fam114a1-/-) reduces cardiomyocyte hypertrophy, inflammation, and cardiac fibrosis, while restoring cardiac function in angiotensin II-induced and MI-induced heart failure models. This indicates its significant role in cardiac remodeling [1]. In melanocytes, inhibition of Fam114a1 increases proliferation, migration, and melanin synthesis proteins, and decreases apoptosis, suggesting its regulatory function in melanocyte biology [2]. In hepatocellular carcinoma cells, suppression of Fam114a1 reduces cell proliferation and migration by modulating AKT1, promotes apoptosis, arrests the cell cycle, and inhibits epithelial-mesenchymal transition (EMT) [3].
In conclusion, Fam114a1 has essential functions in multiple biological processes, especially in cardiac remodeling, melanocyte function, and hepatocellular carcinoma development. The gene knockout mouse models have been instrumental in revealing its role in these disease-related processes, providing potential therapeutic targets for heart diseases and hepatocellular carcinoma, and insights into melanocyte-related disorders [1,2,3].
References:
1. Subbaiah, Kadiam C Venkata, Wu, Jiangbin, Tang, Wai Hong Wilson, Yao, Peng. 2022. FAM114A1 influences cardiac pathological remodeling by regulating angiotensin II signaling. In JCI insight, 7, . doi:10.1172/jci.insight.152783. https://pubmed.ncbi.nlm.nih.gov/35671117/
2. Zhou, Miaoni, Lin, Fuquan, Wu, Xingang, Jin, Rong, Xu, Aie. 2021. Inhibition of Fam114A1 protects melanocytes from apoptosis through higher RACK1 expression. In Aging, 13, 24740-24752. doi:10.18632/aging.203712. https://pubmed.ncbi.nlm.nih.gov/34837888/
3. Zhang, Haifeng, Zeng, Yu, Ye, Chihua, Cai, Jianwu, Hu, Xiao. . Inhibition of FAM114A1 Suppresses Hepatocellular Carcinoma by Targeting AKT1 Signaling. In Annals of clinical and laboratory science, 54, 378-387. doi:. https://pubmed.ncbi.nlm.nih.gov/39048162/
4. Hayashi, Norifumi, Kumar, Sudhir, Trivin-Avillach, Claire, Furuichi, Kengo, Beck, Laurence H. 2025. Characterization of FAM114A1: a novel podocyte cytoskeleton-associated protein upregulated in glomerular injury. In American journal of physiology. Renal physiology, 328, F289-F299. doi:10.1152/ajprenal.00203.2024. https://pubmed.ncbi.nlm.nih.gov/39819080/
5. Stobdan, Tsering, Sahoo, Debashis, Haddad, Gabriel G. 2022. A Boolean approach for novel hypoxia-related gene discovery. In PloS one, 17, e0273524. doi:10.1371/journal.pone.0273524. https://pubmed.ncbi.nlm.nih.gov/36006949/
6. Welch, Lawrence G, Muschalik, Nadine, Munro, Sean. 2024. The FAM114A proteins are adaptors for the recycling of Golgi enzymes. In Journal of cell science, 137, . doi:10.1242/jcs.262160. https://pubmed.ncbi.nlm.nih.gov/39129673/
7. Sung, H, Camargo, M C, Yu, K, Albanes, D, Rabkin, C S. 2015. Association of 4p14 TLR locus with antibodies to Helicobacter pylori. In Genes and immunity, 16, 567-70. doi:10.1038/gene.2015.33. https://pubmed.ncbi.nlm.nih.gov/26312625/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen